Memantine Effects on Electroencephalographic Measures of Putative Excitatory/Inhibitory Balance in Schizophrenia

Abnormalities in cortical excitation and inhibition (E/I) balance are thought to underlie sensory and information processing deficits in schizophrenia. Deficits in early auditory information processing mediate both neurocognitive and functional impairment and appear to be normalized by acute pharmac...

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Vydané v:	Biological psychiatry : cognitive neuroscience and neuroimaging Ročník 5; číslo 6; s. 562 - 568
Hlavní autori:	Molina, Juan L., Voytek, Bradley, Thomas, Michael L., Joshi, Yash B., Bhakta, Savita G., Talledo, Jo A., Swerdlow, Neal R., Light, Gregory A.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 01.06.2020
Predmet:	Cognition Double-Blind Method Early auditory information processing Electroencephalography Excitation/inhibition balance Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Humans Memantine Memantine - pharmacology Memantine - therapeutic use Schizophrenia Schizophrenia - drug therapy Schizophrenia Cognition Electroencephalography Memantine Early auditory information processing Excitation/inhibition balance
ISSN:	2451-9022, 2451-9030, 2451-9030
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Abstract	Abnormalities in cortical excitation and inhibition (E/I) balance are thought to underlie sensory and information processing deficits in schizophrenia. Deficits in early auditory information processing mediate both neurocognitive and functional impairment and appear to be normalized by acute pharmacologic challenge with the NMDA antagonist memantine (MEM). Thirty-six subjects with a diagnosis of schizophrenia and 31 healthy control subjects underwent electroencephalographic recordings. Subjects ingested either placebo or MEM (10 or 20 mg) in a double-blind, within-subject, crossover, randomized design. The aperiodic, 1/f-like scaling property of the neural power spectra, which is thought to index relative E/I balance, was estimated using a robust linear regression algorithm. Patients with schizophrenia had greater aperiodic components compared with healthy control subjects (p < .01, d = 0.64), which was normalized after 20 mg MEM. Analysis revealed a significant dose × diagnosis interaction (p < .0001, d = 0.82). Furthermore, the MEM effect (change in aperiodic component in MEM vs. placebo conditions) was associated with baseline attention and vigilance (r = .54, p < .05) and MEM-induced enhancements in gamma power (r = −.60, p < .01). Findings confirmed E/I balance abnormalities in schizophrenia that were normalized with acute MEM administration and suggest that neurocognitive profiles may predict treatment response based on E/I sensitivity. These data provide proof-of-concept evidence for the utility of E/I balance indices as metrics of acute pharmacologic sensitivity for central nervous system therapeutics.
AbstractList	Abnormalities in cortical excitation and inhibition (E/I) balance are thought to underlie sensory and information processing deficits in schizophrenia. Deficits in early auditory information processing mediate both neurocognitive and functional impairment and appear to be normalized by acute pharmacologic challenge with the NMDA antagonist memantine (MEM).BACKGROUNDAbnormalities in cortical excitation and inhibition (E/I) balance are thought to underlie sensory and information processing deficits in schizophrenia. Deficits in early auditory information processing mediate both neurocognitive and functional impairment and appear to be normalized by acute pharmacologic challenge with the NMDA antagonist memantine (MEM).Thirty-six subjects with a diagnosis of schizophrenia and 31 healthy control subjects underwent electroencephalographic recordings. Subjects ingested either placebo or MEM (10 or 20 mg) in a double-blind, within-subject, crossover, randomized design. The aperiodic, 1/f-like scaling property of the neural power spectra, which is thought to index relative E/I balance, was estimated using a robust linear regression algorithm.METHODSThirty-six subjects with a diagnosis of schizophrenia and 31 healthy control subjects underwent electroencephalographic recordings. Subjects ingested either placebo or MEM (10 or 20 mg) in a double-blind, within-subject, crossover, randomized design. The aperiodic, 1/f-like scaling property of the neural power spectra, which is thought to index relative E/I balance, was estimated using a robust linear regression algorithm.Patients with schizophrenia had greater aperiodic components compared with healthy control subjects (p < .01, d = 0.64), which was normalized after 20 mg MEM. Analysis revealed a significant dose × diagnosis interaction (p < .0001, d = 0.82). Furthermore, the MEM effect (change in aperiodic component in MEM vs. placebo conditions) was associated with baseline attention and vigilance (r = .54, p < .05) and MEM-induced enhancements in gamma power (r = -.60, p < .01).RESULTSPatients with schizophrenia had greater aperiodic components compared with healthy control subjects (p < .01, d = 0.64), which was normalized after 20 mg MEM. Analysis revealed a significant dose × diagnosis interaction (p < .0001, d = 0.82). Furthermore, the MEM effect (change in aperiodic component in MEM vs. placebo conditions) was associated with baseline attention and vigilance (r = .54, p < .05) and MEM-induced enhancements in gamma power (r = -.60, p < .01).Findings confirmed E/I balance abnormalities in schizophrenia that were normalized with acute MEM administration and suggest that neurocognitive profiles may predict treatment response based on E/I sensitivity. These data provide proof-of-concept evidence for the utility of E/I balance indices as metrics of acute pharmacologic sensitivity for central nervous system therapeutics.CONCLUSIONSFindings confirmed E/I balance abnormalities in schizophrenia that were normalized with acute MEM administration and suggest that neurocognitive profiles may predict treatment response based on E/I sensitivity. These data provide proof-of-concept evidence for the utility of E/I balance indices as metrics of acute pharmacologic sensitivity for central nervous system therapeutics. Abnormalities in cortical excitation and inhibition (E/I) balance are thought to underlie sensory and information processing deficits in schizophrenia. Deficits in early auditory information processing mediate both neurocognitive and functional impairment and appear to be normalized by acute pharmacologic challenge with the NMDA antagonist memantine (MEM). Thirty-six subjects with a diagnosis of schizophrenia and 31 healthy control subjects underwent electroencephalographic recordings. Subjects ingested either placebo or MEM (10 or 20 mg) in a double-blind, within-subject, crossover, randomized design. The aperiodic, 1/f-like scaling property of the neural power spectra, which is thought to index relative E/I balance, was estimated using a robust linear regression algorithm. Patients with schizophrenia had greater aperiodic components compared with healthy control subjects (p < .01, d = 0.64), which was normalized after 20 mg MEM. Analysis revealed a significant dose × diagnosis interaction (p < .0001, d = 0.82). Furthermore, the MEM effect (change in aperiodic component in MEM vs. placebo conditions) was associated with baseline attention and vigilance (r = .54, p < .05) and MEM-induced enhancements in gamma power (r = -.60, p < .01). Findings confirmed E/I balance abnormalities in schizophrenia that were normalized with acute MEM administration and suggest that neurocognitive profiles may predict treatment response based on E/I sensitivity. These data provide proof-of-concept evidence for the utility of E/I balance indices as metrics of acute pharmacologic sensitivity for central nervous system therapeutics. Abnormalities in cortical excitation and inhibition (E/I) balance are thought to underlie sensory and information processing deficits in schizophrenia. Deficits in early auditory information processing mediate both neurocognitive and functional impairment and appear to be normalized by acute pharmacologic challenge with the NMDA antagonist memantine (MEM). Thirty-six subjects with a diagnosis of schizophrenia and 31 healthy control subjects underwent electroencephalographic recordings. Subjects ingested either placebo or MEM (10 or 20 mg) in a double-blind, within-subject, crossover, randomized design. The aperiodic, 1/f-like scaling property of the neural power spectra, which is thought to index relative E/I balance, was estimated using a robust linear regression algorithm. Patients with schizophrenia had greater aperiodic components compared with healthy control subjects (p < .01, d = 0.64), which was normalized after 20 mg MEM. Analysis revealed a significant dose × diagnosis interaction (p < .0001, d = 0.82). Furthermore, the MEM effect (change in aperiodic component in MEM vs. placebo conditions) was associated with baseline attention and vigilance (r = .54, p < .05) and MEM-induced enhancements in gamma power (r = −.60, p < .01). Findings confirmed E/I balance abnormalities in schizophrenia that were normalized with acute MEM administration and suggest that neurocognitive profiles may predict treatment response based on E/I sensitivity. These data provide proof-of-concept evidence for the utility of E/I balance indices as metrics of acute pharmacologic sensitivity for central nervous system therapeutics.
Author	Talledo, Jo A. Voytek, Bradley Joshi, Yash B. Bhakta, Savita G. Swerdlow, Neal R. Light, Gregory A. Thomas, Michael L. Molina, Juan L.
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Cites_doi	10.1038/npp.2015.162 10.1038/nature10360 10.1016/j.neuron.2013.10.031 10.1001/jamapsychiatry.2016.2980 10.1016/j.phrs.2004.05.005 10.1016/0165-1781(95)02712-6 10.1016/j.biopsych.2014.07.022 10.1001/jamapsychiatry.2016.0442 10.1007/s00213-002-1040-3 10.1523/JNEUROSCI.5297-05.2006 10.1016/j.tics.2014.04.003 10.1002/syn.20472 10.1016/S1388-2457(99)00322-3 10.1523/JNEUROSCI.1234-11.2011 10.1093/oxfordjournals.schbul.a033430 10.1176/appi.ajp.2012.12030305 10.1248/bpb.32.850 10.1016/j.neuroimage.2018.06.068 10.1073/pnas.1608819113 10.1016/j.tics.2011.11.015 10.1176/ajp.2006.163.11.1960 10.1016/j.nbd.2016.08.006 10.1016/j.schres.2016.10.011 10.1016/j.neuron.2019.01.017 10.1093/cercor/10.11.1078 10.1162/jocn.2007.19.10.1624 10.1016/j.biopsych.2004.10.019 10.1038/nn.3220 10.1038/npp.2017.25 10.25080/Majora-92bf1922-011 10.1176/appi.ajp.2011.11010052 10.1162/neco.1995.7.6.1129 10.1523/JNEUROSCI.2332-14.2015 10.1038/nrn2462 10.1038/npp.2017.81 10.1016/j.neuroimage.2017.06.078 10.1038/npp.2015.26 10.1016/j.biopsych.2015.04.016 10.1016/j.neuron.2010.04.020 10.1016/j.scog.2014.02.001 10.1038/s41598-018-31163-5 10.1523/JNEUROSCI.1173-17.2017 10.1038/nrn2229 10.1523/JNEUROSCI.2488-10.2010 10.1152/jn.00943.2014 10.1016/j.neuroimage.2019.01.024 10.1038/mp.2012.137 10.1038/nn.2177 10.1001/archpsyc.1992.01820120015004 10.1016/j.schres.2017.05.020 10.1073/pnas.1208494109 10.1093/cercor/bhs370 10.1176/appi.ajp.161.3.490
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Keywords	Schizophrenia Cognition Electroencephalography Memantine Early auditory information processing Excitation/inhibition balance
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References	Seeman, Caruso, Lasaga (bib43) 2008; 62 Podvalny, Noy, Harel, Bickel, Chechik, Schroeder (bib24) 2015; 114 Colombo, Napolitani, Boly, Gosseries, Casarotto, Rosanova (bib51) 2019; 189 Yizhar, Fenno, Prigge, Schneider, Davidson, O’Shea (bib12) 2011; 477 Wolff, Bygrave, Sanderson, Boyden, Bannerman, Kullmann, Kätzel (bib11) 2018; 8 Bell, Sejnowski (bib34) 1995; 7 Haller, Donoghue, Peterson, Varma, Sebastian, Gao (bib35) 2018 Joshi, Breitenstein, Tarasenko, Thomas, Chang, Sprock (bib58) 2018; 191 Torrey, Barci, Webster, Bartko, Meador-Woodruff, Knable (bib10) 2005; 57 Nir, Mukamel, Dinstein, Privman, Harel, Fisch (bib22) 2008; 11 Winterer, Musso, Beckmann, Mattay, Egan, Jones (bib53) 2006; 163 Light, Zhang, Joshi, Bhakta, Talledo, Swerdlow (bib28) 2017; 42 Xia, Chen, Zhang, Lipton (bib42) 2010; 30 Green, Harvey (bib2) 2014; 1 Swerdlow NR, Bhakta SG, Clifford R, Talledo J, Kotz JE, Benster L Muthukumaraswamy, Liley (bib50) 2018; 179 Seabold S, Perktold J: Statsmodels: Econometric and statistical modeling with Python, Proceedings of the 9th Python in Science Conference. July 1, 2010, Austin, Texas. Sonkusare, Kaul, Ramarao (bib31) 2005; 51 Winterer, Ziller, Dorn, Frick, Mulert, Wuebben (bib57) 2000; 111 Demirtaş, Burt, Helmer, Ji, Adkinson, Glasser (bib17) 2019; 101 He, Zempel, Snyder, Raichle (bib23) 2010; 66 Peterson, Rosen, Campbell, Belger, Voytek (bib26) 2018 Glasgow, Povysheva, Azofeifa, Johnson (bib44) 2017; 37 Lee, Gee, Vogt, Patel, Rubenstein, Sohal (bib21) 2014; 81 Hyde, Lipska, Ali, Mathew, Law, Metitiri (bib8) 2011; 31 Berman, Torrey, Daniel, Weinberger (bib55) 1992; 49 Thomas, Green, Hellemann, Sugar, Tarasenko, Calkins (bib3) 2017; 74 Anticevic, Gancsos, Murray, Repovs, Driesen, Ennis (bib7) 2012; 109 Callicott, Bertolino, Mattay, Langheim, Duyn, Coppola (bib52) 2000; 10 Bates, Mächler, Bolker, Walker (bib36) 2015; 67 Volk, Matsubara, Li, Sengupta, Georgiev, Minabe (bib39) 2012; 169 Starc, Murray, Santamauro, Savic, Diehl, Cho (bib13) 2017; 181 Perez, Tarasenko, Miyakoshi, Pianka, Makeig, Braff (bib33) 2017; 42 Povysheva, Johnson (bib29) 2016; 96 Rolls, Loh, Deco, Winterer (bib18) 2008; 9 Lipton (bib30) 2007; 8 Cuesta, Peralta (bib4) 1995; 58 Yang, Murray, Wang, Glahn, Pearlson, Repovs (bib15) 2016; 113 Haider, Duque, Hasenstaub, McCormick (bib19) 2006; 26 Aida, Yoshida, Nomura, Tanimura, Iino, Soma (bib47) 2015; 40 Green, Kern, Braff, Mintz (bib5) 2000; 26 Litwin-Kumar, Doiron (bib20) 2012; 15 Curley, Arion, Volk, Asafu-Adjei, Sampson, Fish, Lewis (bib9) 2011; 168 Weickert, Fung, Catts, Schofield, Allen, Moore (bib40) 2013; 18 Voytek, Knight (bib56) 2015; 77 Braun, Schäfer, Bassett, Rausch, Schweiger, Bilek (bib6) 2016; 113 Swerdlow, Bhakta, Chou, Talledo, Balvaneda, Light (bib27) 2016; 41 Merritt, Egerton, Kempton, Taylor, McGuire (bib41) 2016; 73 Voytek, Kramer, Case, Lepage, Tempesta, Knight, Gazzaley (bib25) 2015; 35 Swerdlow, Eastvold, Karban, Ploum, Stephany, Geyer (bib46) 2002; 161 Onogi, Ishigaki, Nakagawasai, Arai-Kato, Arai, Watanabe (bib45) 2009; 32 He (bib49) 2014; 18 Memantine enhances measures of auditory fidelity and learning in schizophrenia. In: Proceedings of the American College of Neuropsychopharmacology, December 9, 2019, Orlando, FL: M159. Winterer, Coppola, Goldberg, Egan, Jones, Sanchez, Weinberger (bib54) 2004; 161 Barch, Ceaser (bib1) 2012; 16 Murray, Anticevic, Gancsos, Ichinose, Corlett, Krystal, Wang (bib16) 2014; 24 Light, Swerdlow, Braff (bib32) 2007; 19 Anticevic, Corlett, Cole, Savic, Gancsos, Tang (bib14) 2015; 77 Gao, Peterson, Voytek (bib48) 2017; 158 Starc (10.1016/j.bpsc.2020.02.004_bib13) 2017; 181 Demirtaş (10.1016/j.bpsc.2020.02.004_bib17) 2019; 101 Curley (10.1016/j.bpsc.2020.02.004_bib9) 2011; 168 Lipton (10.1016/j.bpsc.2020.02.004_bib30) 2007; 8 Cuesta (10.1016/j.bpsc.2020.02.004_bib4) 1995; 58 Lee (10.1016/j.bpsc.2020.02.004_bib21) 2014; 81 Berman (10.1016/j.bpsc.2020.02.004_bib55) 1992; 49 Yang (10.1016/j.bpsc.2020.02.004_bib15) 2016; 113 Nir (10.1016/j.bpsc.2020.02.004_bib22) 2008; 11 Hyde (10.1016/j.bpsc.2020.02.004_bib8) 2011; 31 Joshi (10.1016/j.bpsc.2020.02.004_bib58) 2018; 191 Anticevic (10.1016/j.bpsc.2020.02.004_bib7) 2012; 109 Light (10.1016/j.bpsc.2020.02.004_bib32) 2007; 19 Colombo (10.1016/j.bpsc.2020.02.004_bib51) 2019; 189 Perez (10.1016/j.bpsc.2020.02.004_bib33) 2017; 42 Green (10.1016/j.bpsc.2020.02.004_bib2) 2014; 1 Bates (10.1016/j.bpsc.2020.02.004_bib36) 2015; 67 Povysheva (10.1016/j.bpsc.2020.02.004_bib29) 2016; 96 Weickert (10.1016/j.bpsc.2020.02.004_bib40) 2013; 18 Torrey (10.1016/j.bpsc.2020.02.004_bib10) 2005; 57 Gao (10.1016/j.bpsc.2020.02.004_bib48) 2017; 158 Wolff (10.1016/j.bpsc.2020.02.004_bib11) 2018; 8 Aida (10.1016/j.bpsc.2020.02.004_bib47) 2015; 40 Peterson (10.1016/j.bpsc.2020.02.004_bib26) 2018 Voytek (10.1016/j.bpsc.2020.02.004_bib25) 2015; 35 10.1016/j.bpsc.2020.02.004_bib37 10.1016/j.bpsc.2020.02.004_bib38 Merritt (10.1016/j.bpsc.2020.02.004_bib41) 2016; 73 Haider (10.1016/j.bpsc.2020.02.004_bib19) 2006; 26 Podvalny (10.1016/j.bpsc.2020.02.004_bib24) 2015; 114 Thomas (10.1016/j.bpsc.2020.02.004_bib3) 2017; 74 Anticevic (10.1016/j.bpsc.2020.02.004_bib14) 2015; 77 Volk (10.1016/j.bpsc.2020.02.004_bib39) 2012; 169 Winterer (10.1016/j.bpsc.2020.02.004_bib53) 2006; 163 Winterer (10.1016/j.bpsc.2020.02.004_bib54) 2004; 161 He (10.1016/j.bpsc.2020.02.004_bib49) 2014; 18 Haller (10.1016/j.bpsc.2020.02.004_bib35) 2018 Swerdlow (10.1016/j.bpsc.2020.02.004_bib46) 2002; 161 Yizhar (10.1016/j.bpsc.2020.02.004_bib12) 2011; 477 He (10.1016/j.bpsc.2020.02.004_bib23) 2010; 66 Light (10.1016/j.bpsc.2020.02.004_bib28) 2017; 42 Swerdlow (10.1016/j.bpsc.2020.02.004_bib27) 2016; 41 Muthukumaraswamy (10.1016/j.bpsc.2020.02.004_bib50) 2018; 179 Barch (10.1016/j.bpsc.2020.02.004_bib1) 2012; 16 Murray (10.1016/j.bpsc.2020.02.004_bib16) 2014; 24 Sonkusare (10.1016/j.bpsc.2020.02.004_bib31) 2005; 51 Onogi (10.1016/j.bpsc.2020.02.004_bib45) 2009; 32 Xia (10.1016/j.bpsc.2020.02.004_bib42) 2010; 30 Bell (10.1016/j.bpsc.2020.02.004_bib34) 1995; 7 Voytek (10.1016/j.bpsc.2020.02.004_bib56) 2015; 77 Rolls (10.1016/j.bpsc.2020.02.004_bib18) 2008; 9 Seeman (10.1016/j.bpsc.2020.02.004_bib43) 2008; 62 Callicott (10.1016/j.bpsc.2020.02.004_bib52) 2000; 10 Litwin-Kumar (10.1016/j.bpsc.2020.02.004_bib20) 2012; 15 Winterer (10.1016/j.bpsc.2020.02.004_bib57) 2000; 111 Braun (10.1016/j.bpsc.2020.02.004_bib6) 2016; 113 Glasgow (10.1016/j.bpsc.2020.02.004_bib44) 2017; 37 Green (10.1016/j.bpsc.2020.02.004_bib5) 2000; 26
References_xml	– start-page: 299859 year: 2018 ident: bib35 article-title: Parameterizing neural power spectra publication-title: bioRxiv – volume: 9 start-page: 696 year: 2008 end-page: 709 ident: bib18 article-title: Computational models of schizophrenia and dopamine modulation in the prefrontal cortex publication-title: Nat Rev Neurosci – volume: 191 start-page: 5 year: 2018 end-page: 9 ident: bib58 article-title: Mismatch negativity impairment is associated with deficits in identifying real-world environmental sounds in schizophrenia publication-title: Schizophr Res – volume: 42 start-page: 2206 year: 2017 end-page: 2213 ident: bib33 article-title: Mismatch negativity is a sensitive and predictive biomarker of perceptual learning during auditory cognitive training in schizophrenia publication-title: Neuropsychopharmacology – volume: 163 start-page: 1960 year: 2006 end-page: 1968 ident: bib53 article-title: Instability of prefrontal signal processing in schizophrenia publication-title: Am J Psychiatry – volume: 7 start-page: 1129 year: 1995 end-page: 1159 ident: bib34 article-title: An information-maximization approach to blind separation and blind deconvolution publication-title: Neural Comput – volume: 1 start-page: e1 year: 2014 end-page: e9 ident: bib2 article-title: Cognition in schizophrenia: Past, present, and future publication-title: Schizophr Res Cogn – volume: 19 start-page: 1624 year: 2007 end-page: 1632 ident: bib32 article-title: Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adults publication-title: J Cogn Neurosci – volume: 77 start-page: 1089 year: 2015 end-page: 1097 ident: bib56 article-title: Dynamic network communication as a unifying neural basis for cognition, development, aging, and disease publication-title: Biol Psychiatry – volume: 24 start-page: 859 year: 2014 end-page: 872 ident: bib16 article-title: Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model publication-title: Cereb Cortex – volume: 49 start-page: 927 year: 1992 end-page: 934 ident: bib55 article-title: Regional cerebral blood flow in monozygotic twins discordant and concordant for schizophrenia publication-title: Arch Gen Psychiatry – start-page: 113449 year: 2018 ident: bib26 article-title: 1 publication-title: bioRxiv – volume: 15 start-page: 1498 year: 2012 end-page: 1505 ident: bib20 article-title: Slow dynamics and high variability in balanced cortical networks with clustered connections publication-title: Nat Neurosci – volume: 73 start-page: 665 year: 2016 end-page: 674 ident: bib41 article-title: Nature of glutamate alterations in schizophrenia: A meta-analysis of proton magnetic resonance spectroscopy studies publication-title: JAMA Psychiatry – volume: 41 start-page: 419 year: 2016 end-page: 430 ident: bib27 article-title: Memantine effects on sensorimotor gating and mismatch negativity in patients with chronic psychosis publication-title: Neuropsychopharmacology – volume: 8 start-page: 803 year: 2007 end-page: 808 ident: bib30 article-title: Pathologically activated therapeutics for neuroprotection publication-title: Nat Rev Neurosci – volume: 113 start-page: E219 year: 2016 end-page: E228 ident: bib15 article-title: Functional hierarchy underlies preferential connectivity disturbances in schizophrenia publication-title: Proc Natl Acad Sci U S A – volume: 189 start-page: 631 year: 2019 end-page: 644 ident: bib51 article-title: The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine publication-title: Neuroimage – volume: 18 start-page: 1185 year: 2013 end-page: 1192 ident: bib40 article-title: Molecular evidence of publication-title: Mol Psychiatry – volume: 168 start-page: 921 year: 2011 end-page: 929 ident: bib9 article-title: Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: Clinical, protein, and cell type-specific features publication-title: Am J Psychiatry – volume: 161 start-page: 490 year: 2004 end-page: 500 ident: bib54 article-title: Prefrontal broadband noise, working memory, and genetic risk for schizophrenia publication-title: Am J Psychiatry – volume: 169 start-page: 1082 year: 2012 end-page: 1091 ident: bib39 article-title: Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia publication-title: Am J Psychiatry – volume: 111 start-page: 837 year: 2000 end-page: 849 ident: bib57 article-title: Schizophrenia: Reduced signal-to-noise ratio and impaired phase-locking during information processing publication-title: Clin Neurophysiol – volume: 96 start-page: 75 year: 2016 end-page: 83 ident: bib29 article-title: Effects of memantine on the excitation-inhibition balance in prefrontal cortex publication-title: Neurobiol Dis – volume: 37 start-page: 9686 year: 2017 end-page: 9704 ident: bib44 article-title: Memantine and ketamine differentially alter NMDA receptor desensitization publication-title: J Neurosci – volume: 35 start-page: 13257 year: 2015 end-page: 13265 ident: bib25 article-title: Age-related changes in 1/ publication-title: J Neurosci – volume: 57 start-page: 252 year: 2005 end-page: 260 ident: bib10 article-title: Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains publication-title: Biol Psychiatry – reference: Memantine enhances measures of auditory fidelity and learning in schizophrenia. In: Proceedings of the American College of Neuropsychopharmacology, December 9, 2019, Orlando, FL: M159. – reference: Swerdlow NR, Bhakta SG, Clifford R, Talledo J, Kotz JE, Benster L, – volume: 109 start-page: 16720 year: 2012 end-page: 16725 ident: bib7 article-title: NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia publication-title: Proc Natl Acad Sci U S A – volume: 74 start-page: 37 year: 2017 end-page: 46 ident: bib3 article-title: Modeling deficits from early auditory information processing to psychosocial functioning in schizophrenia publication-title: JAMA Psychiatry – volume: 158 start-page: 70 year: 2017 end-page: 78 ident: bib48 article-title: Inferring synaptic excitation/inhibition balance from field potentials publication-title: Neuroimage – volume: 477 start-page: 171 year: 2011 end-page: 178 ident: bib12 article-title: Neocortical excitation/inhibition balance in information processing and social dysfunction publication-title: Nature – volume: 77 start-page: 569 year: 2015 end-page: 580 ident: bib14 article-title: -methyl-D-aspartate receptor antagonist effects on prefrontal cortical connectivity better model early than chronic schizophrenia publication-title: Biol Psychiatry – volume: 67 start-page: 1 year: 2015 end-page: 48 ident: bib36 article-title: Fitting linear mixed-effects models using lme4 publication-title: J Stat Softw – volume: 51 start-page: 1 year: 2005 end-page: 17 ident: bib31 article-title: Dementia of Alzheimer’s disease and other neurodegenerative disorders—memantine, a new hope publication-title: Pharmacol Res – volume: 31 start-page: 11088 year: 2011 end-page: 11095 ident: bib8 article-title: Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia publication-title: J Neurosci – volume: 30 start-page: 11246 year: 2010 end-page: 11250 ident: bib42 article-title: Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses publication-title: J Neurosci – volume: 11 start-page: 1100 year: 2008 end-page: 1108 ident: bib22 article-title: Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex publication-title: Nat Neurosci – volume: 18 start-page: 480 year: 2014 end-page: 487 ident: bib49 article-title: Scale-free brain activity: Past, present, and future publication-title: Trends Cogn Sci – volume: 179 start-page: 582 year: 2018 end-page: 595 ident: bib50 article-title: 1/ publication-title: Neuroimage – volume: 161 start-page: 189 year: 2002 end-page: 201 ident: bib46 article-title: Dopamine agonist effects on startle and sensorimotor gating in normal male subjects: time course studies publication-title: Psychopharmacology (Berl) – volume: 58 start-page: 227 year: 1995 end-page: 235 ident: bib4 article-title: Cognitive disorders in the positive, negative, and disorganization syndromes of schizophrenia publication-title: Psychiatry Res – volume: 114 start-page: 505 year: 2015 end-page: 519 ident: bib24 article-title: A unifying principle underlying the extracellular field potential spectral responses in the human cortex publication-title: J Neurophysiol – volume: 40 start-page: 1569 year: 2015 end-page: 1579 ident: bib47 article-title: Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice publication-title: Neuropsychopharmacology – volume: 181 start-page: 107 year: 2017 end-page: 116 ident: bib13 article-title: Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition publication-title: Schizophr Res – volume: 62 start-page: 149 year: 2008 end-page: 153 ident: bib43 article-title: Memantine agonist action at dopamine D2High receptors publication-title: Synapse – volume: 16 start-page: 27 year: 2012 end-page: 34 ident: bib1 article-title: Cognition in schizophrenia: Core psychological and neural mechanisms publication-title: Trends Cogn Sci – volume: 26 start-page: 119 year: 2000 end-page: 136 ident: bib5 article-title: Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? publication-title: Schizophr Bull – volume: 81 start-page: 61 year: 2014 end-page: 68 ident: bib21 article-title: Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition publication-title: Neuron – volume: 66 start-page: 353 year: 2010 end-page: 369 ident: bib23 article-title: The temporal structures and functional significance of scale-free brain activity publication-title: Neuron – volume: 10 start-page: 1078 year: 2000 end-page: 1092 ident: bib52 article-title: Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited publication-title: Cereb Cortex – volume: 113 start-page: 12568 year: 2016 end-page: 12573 ident: bib6 article-title: Dynamic brain network reconfiguration as a potential schizophrenia genetic risk mechanism modulated by NMDA receptor function publication-title: Proc Natl Acad Sci U S A – volume: 32 start-page: 850 year: 2009 end-page: 855 ident: bib45 article-title: Influence of memantine on brain monoaminergic neurotransmission parameters in mice: neurochemical and behavioral study publication-title: Biol Pharm Bull – volume: 8 start-page: 12871 year: 2018 ident: bib11 article-title: Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms publication-title: Sci Rep – volume: 26 start-page: 4535 year: 2006 end-page: 4545 ident: bib19 article-title: Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition publication-title: J Neurosci – reference: Seabold S, Perktold J: Statsmodels: Econometric and statistical modeling with Python, Proceedings of the 9th Python in Science Conference. July 1, 2010, Austin, Texas. – volume: 42 start-page: 2633 year: 2017 end-page: 2639 ident: bib28 article-title: Single-dose memantine improves cortical oscillatory response dynamics in patients with schizophrenia publication-title: Neuropsychopharmacology – volume: 101 start-page: 1181 year: 2019 end-page: 1194.e13 ident: bib17 article-title: Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics publication-title: Neuron – volume: 41 start-page: 419 year: 2016 ident: 10.1016/j.bpsc.2020.02.004_bib27 article-title: Memantine effects on sensorimotor gating and mismatch negativity in patients with chronic psychosis publication-title: Neuropsychopharmacology doi: 10.1038/npp.2015.162 – volume: 113 start-page: E219 year: 2016 ident: 10.1016/j.bpsc.2020.02.004_bib15 article-title: Functional hierarchy underlies preferential connectivity disturbances in schizophrenia publication-title: Proc Natl Acad Sci U S A – volume: 477 start-page: 171 year: 2011 ident: 10.1016/j.bpsc.2020.02.004_bib12 article-title: Neocortical excitation/inhibition balance in information processing and social dysfunction publication-title: Nature doi: 10.1038/nature10360 – volume: 81 start-page: 61 year: 2014 ident: 10.1016/j.bpsc.2020.02.004_bib21 article-title: Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition publication-title: Neuron doi: 10.1016/j.neuron.2013.10.031 – volume: 74 start-page: 37 year: 2017 ident: 10.1016/j.bpsc.2020.02.004_bib3 article-title: Modeling deficits from early auditory information processing to psychosocial functioning in schizophrenia publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2016.2980 – volume: 51 start-page: 1 year: 2005 ident: 10.1016/j.bpsc.2020.02.004_bib31 article-title: Dementia of Alzheimer’s disease and other neurodegenerative disorders—memantine, a new hope publication-title: Pharmacol Res doi: 10.1016/j.phrs.2004.05.005 – volume: 58 start-page: 227 year: 1995 ident: 10.1016/j.bpsc.2020.02.004_bib4 article-title: Cognitive disorders in the positive, negative, and disorganization syndromes of schizophrenia publication-title: Psychiatry Res doi: 10.1016/0165-1781(95)02712-6 – volume: 77 start-page: 569 year: 2015 ident: 10.1016/j.bpsc.2020.02.004_bib14 article-title: N-methyl-D-aspartate receptor antagonist effects on prefrontal cortical connectivity better model early than chronic schizophrenia publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2014.07.022 – volume: 73 start-page: 665 year: 2016 ident: 10.1016/j.bpsc.2020.02.004_bib41 article-title: Nature of glutamate alterations in schizophrenia: A meta-analysis of proton magnetic resonance spectroscopy studies publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2016.0442 – volume: 161 start-page: 189 year: 2002 ident: 10.1016/j.bpsc.2020.02.004_bib46 article-title: Dopamine agonist effects on startle and sensorimotor gating in normal male subjects: time course studies publication-title: Psychopharmacology (Berl) doi: 10.1007/s00213-002-1040-3 – volume: 26 start-page: 4535 year: 2006 ident: 10.1016/j.bpsc.2020.02.004_bib19 article-title: Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition publication-title: J Neurosci doi: 10.1523/JNEUROSCI.5297-05.2006 – volume: 18 start-page: 480 year: 2014 ident: 10.1016/j.bpsc.2020.02.004_bib49 article-title: Scale-free brain activity: Past, present, and future publication-title: Trends Cogn Sci doi: 10.1016/j.tics.2014.04.003 – volume: 62 start-page: 149 year: 2008 ident: 10.1016/j.bpsc.2020.02.004_bib43 article-title: Memantine agonist action at dopamine D2High receptors publication-title: Synapse doi: 10.1002/syn.20472 – volume: 111 start-page: 837 year: 2000 ident: 10.1016/j.bpsc.2020.02.004_bib57 article-title: Schizophrenia: Reduced signal-to-noise ratio and impaired phase-locking during information processing publication-title: Clin Neurophysiol doi: 10.1016/S1388-2457(99)00322-3 – volume: 31 start-page: 11088 year: 2011 ident: 10.1016/j.bpsc.2020.02.004_bib8 article-title: Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1234-11.2011 – volume: 26 start-page: 119 year: 2000 ident: 10.1016/j.bpsc.2020.02.004_bib5 article-title: Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? publication-title: Schizophr Bull doi: 10.1093/oxfordjournals.schbul.a033430 – volume: 169 start-page: 1082 year: 2012 ident: 10.1016/j.bpsc.2020.02.004_bib39 article-title: Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2012.12030305 – volume: 32 start-page: 850 year: 2009 ident: 10.1016/j.bpsc.2020.02.004_bib45 article-title: Influence of memantine on brain monoaminergic neurotransmission parameters in mice: neurochemical and behavioral study publication-title: Biol Pharm Bull doi: 10.1248/bpb.32.850 – volume: 179 start-page: 582 year: 2018 ident: 10.1016/j.bpsc.2020.02.004_bib50 article-title: 1/f electrophysiological spectra in resting and drug-induced states can be explained by the dynamics of multiple oscillatory relaxation processes publication-title: Neuroimage doi: 10.1016/j.neuroimage.2018.06.068 – volume: 113 start-page: 12568 year: 2016 ident: 10.1016/j.bpsc.2020.02.004_bib6 article-title: Dynamic brain network reconfiguration as a potential schizophrenia genetic risk mechanism modulated by NMDA receptor function publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1608819113 – volume: 16 start-page: 27 year: 2012 ident: 10.1016/j.bpsc.2020.02.004_bib1 article-title: Cognition in schizophrenia: Core psychological and neural mechanisms publication-title: Trends Cogn Sci doi: 10.1016/j.tics.2011.11.015 – volume: 163 start-page: 1960 year: 2006 ident: 10.1016/j.bpsc.2020.02.004_bib53 article-title: Instability of prefrontal signal processing in schizophrenia publication-title: Am J Psychiatry doi: 10.1176/ajp.2006.163.11.1960 – start-page: 113449 year: 2018 ident: 10.1016/j.bpsc.2020.02.004_bib26 article-title: 1/f neural noise is a better predictor of schizophrenia than neural oscillations publication-title: bioRxiv – volume: 96 start-page: 75 year: 2016 ident: 10.1016/j.bpsc.2020.02.004_bib29 article-title: Effects of memantine on the excitation-inhibition balance in prefrontal cortex publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2016.08.006 – volume: 181 start-page: 107 year: 2017 ident: 10.1016/j.bpsc.2020.02.004_bib13 article-title: Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition publication-title: Schizophr Res doi: 10.1016/j.schres.2016.10.011 – volume: 101 start-page: 1181 year: 2019 ident: 10.1016/j.bpsc.2020.02.004_bib17 article-title: Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics publication-title: Neuron doi: 10.1016/j.neuron.2019.01.017 – volume: 10 start-page: 1078 year: 2000 ident: 10.1016/j.bpsc.2020.02.004_bib52 article-title: Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited publication-title: Cereb Cortex doi: 10.1093/cercor/10.11.1078 – volume: 19 start-page: 1624 year: 2007 ident: 10.1016/j.bpsc.2020.02.004_bib32 article-title: Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adults publication-title: J Cogn Neurosci doi: 10.1162/jocn.2007.19.10.1624 – volume: 57 start-page: 252 year: 2005 ident: 10.1016/j.bpsc.2020.02.004_bib10 article-title: Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2004.10.019 – volume: 15 start-page: 1498 year: 2012 ident: 10.1016/j.bpsc.2020.02.004_bib20 article-title: Slow dynamics and high variability in balanced cortical networks with clustered connections publication-title: Nat Neurosci doi: 10.1038/nn.3220 – volume: 42 start-page: 2206 year: 2017 ident: 10.1016/j.bpsc.2020.02.004_bib33 article-title: Mismatch negativity is a sensitive and predictive biomarker of perceptual learning during auditory cognitive training in schizophrenia publication-title: Neuropsychopharmacology doi: 10.1038/npp.2017.25 – ident: 10.1016/j.bpsc.2020.02.004_bib37 doi: 10.25080/Majora-92bf1922-011 – volume: 168 start-page: 921 year: 2011 ident: 10.1016/j.bpsc.2020.02.004_bib9 article-title: Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: Clinical, protein, and cell type-specific features publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2011.11010052 – volume: 7 start-page: 1129 year: 1995 ident: 10.1016/j.bpsc.2020.02.004_bib34 article-title: An information-maximization approach to blind separation and blind deconvolution publication-title: Neural Comput doi: 10.1162/neco.1995.7.6.1129 – start-page: 299859 year: 2018 ident: 10.1016/j.bpsc.2020.02.004_bib35 article-title: Parameterizing neural power spectra publication-title: bioRxiv – volume: 35 start-page: 13257 year: 2015 ident: 10.1016/j.bpsc.2020.02.004_bib25 article-title: Age-related changes in 1/f neural electrophysiological noise publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2332-14.2015 – volume: 9 start-page: 696 year: 2008 ident: 10.1016/j.bpsc.2020.02.004_bib18 article-title: Computational models of schizophrenia and dopamine modulation in the prefrontal cortex publication-title: Nat Rev Neurosci doi: 10.1038/nrn2462 – volume: 42 start-page: 2633 year: 2017 ident: 10.1016/j.bpsc.2020.02.004_bib28 article-title: Single-dose memantine improves cortical oscillatory response dynamics in patients with schizophrenia publication-title: Neuropsychopharmacology doi: 10.1038/npp.2017.81 – volume: 158 start-page: 70 year: 2017 ident: 10.1016/j.bpsc.2020.02.004_bib48 article-title: Inferring synaptic excitation/inhibition balance from field potentials publication-title: Neuroimage doi: 10.1016/j.neuroimage.2017.06.078 – volume: 40 start-page: 1569 year: 2015 ident: 10.1016/j.bpsc.2020.02.004_bib47 article-title: Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice publication-title: Neuropsychopharmacology doi: 10.1038/npp.2015.26 – volume: 77 start-page: 1089 year: 2015 ident: 10.1016/j.bpsc.2020.02.004_bib56 article-title: Dynamic network communication as a unifying neural basis for cognition, development, aging, and disease publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2015.04.016 – volume: 66 start-page: 353 year: 2010 ident: 10.1016/j.bpsc.2020.02.004_bib23 article-title: The temporal structures and functional significance of scale-free brain activity publication-title: Neuron doi: 10.1016/j.neuron.2010.04.020 – volume: 1 start-page: e1 year: 2014 ident: 10.1016/j.bpsc.2020.02.004_bib2 article-title: Cognition in schizophrenia: Past, present, and future publication-title: Schizophr Res Cogn doi: 10.1016/j.scog.2014.02.001 – volume: 8 start-page: 12871 year: 2018 ident: 10.1016/j.bpsc.2020.02.004_bib11 article-title: Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms publication-title: Sci Rep doi: 10.1038/s41598-018-31163-5 – volume: 37 start-page: 9686 year: 2017 ident: 10.1016/j.bpsc.2020.02.004_bib44 article-title: Memantine and ketamine differentially alter NMDA receptor desensitization publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1173-17.2017 – volume: 8 start-page: 803 year: 2007 ident: 10.1016/j.bpsc.2020.02.004_bib30 article-title: Pathologically activated therapeutics for neuroprotection publication-title: Nat Rev Neurosci doi: 10.1038/nrn2229 – ident: 10.1016/j.bpsc.2020.02.004_bib38 – volume: 30 start-page: 11246 year: 2010 ident: 10.1016/j.bpsc.2020.02.004_bib42 article-title: Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2488-10.2010 – volume: 114 start-page: 505 year: 2015 ident: 10.1016/j.bpsc.2020.02.004_bib24 article-title: A unifying principle underlying the extracellular field potential spectral responses in the human cortex publication-title: J Neurophysiol doi: 10.1152/jn.00943.2014 – volume: 67 start-page: 1 year: 2015 ident: 10.1016/j.bpsc.2020.02.004_bib36 article-title: Fitting linear mixed-effects models using lme4 publication-title: J Stat Softw – volume: 189 start-page: 631 year: 2019 ident: 10.1016/j.bpsc.2020.02.004_bib51 article-title: The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine publication-title: Neuroimage doi: 10.1016/j.neuroimage.2019.01.024 – volume: 18 start-page: 1185 year: 2013 ident: 10.1016/j.bpsc.2020.02.004_bib40 article-title: Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia publication-title: Mol Psychiatry doi: 10.1038/mp.2012.137 – volume: 11 start-page: 1100 year: 2008 ident: 10.1016/j.bpsc.2020.02.004_bib22 article-title: Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex publication-title: Nat Neurosci doi: 10.1038/nn.2177 – volume: 49 start-page: 927 year: 1992 ident: 10.1016/j.bpsc.2020.02.004_bib55 article-title: Regional cerebral blood flow in monozygotic twins discordant and concordant for schizophrenia publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1992.01820120015004 – volume: 191 start-page: 5 year: 2018 ident: 10.1016/j.bpsc.2020.02.004_bib58 article-title: Mismatch negativity impairment is associated with deficits in identifying real-world environmental sounds in schizophrenia publication-title: Schizophr Res doi: 10.1016/j.schres.2017.05.020 – volume: 109 start-page: 16720 year: 2012 ident: 10.1016/j.bpsc.2020.02.004_bib7 article-title: NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1208494109 – volume: 24 start-page: 859 year: 2014 ident: 10.1016/j.bpsc.2020.02.004_bib16 article-title: Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model publication-title: Cereb Cortex doi: 10.1093/cercor/bhs370 – volume: 161 start-page: 490 year: 2004 ident: 10.1016/j.bpsc.2020.02.004_bib54 article-title: Prefrontal broadband noise, working memory, and genetic risk for schizophrenia publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.161.3.490
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Snippet	Abnormalities in cortical excitation and inhibition (E/I) balance are thought to underlie sensory and information processing deficits in schizophrenia....
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SubjectTerms	Cognition Double-Blind Method Early auditory information processing Electroencephalography Excitation/inhibition balance Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Humans Memantine Memantine - pharmacology Memantine - therapeutic use Schizophrenia Schizophrenia - drug therapy
Title	Memantine Effects on Electroencephalographic Measures of Putative Excitatory/Inhibitory Balance in Schizophrenia
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