Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors

Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 (CDK1) is a member of the family of cell cycle regulatory proteins involved in cell cycle maintenance. Given that overexpres...

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Vydané v:	Medical oncology (Northwood, London, England) Ročník 39; číslo 9; s. 133
Hlavní autori:	Sofi, Shazia, Mehraj, Umar, Qayoom, Hina, Aisha, Shariqa, Almilaibary, Abdullah, Alkhanani, Mustfa, Mir, Manzoor Ahmad
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Springer US 20.06.2022 Springer Nature B.V
Predmet:	Breast cancer Cancer Cell cycle Cyclin-dependent kinases Hematology Internal Medicine Kinases Medicine Medicine & Public Health Oncology Original Paper Pathology CDK1 Breast cancer Molecular dynamic simulation Dinaciclib Cell cycle
ISSN:	1559-131X, 1357-0560, 1559-131X
On-line prístup:	Získať plný text
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