Interoceptive pathways to understand and treat mental health conditions

An increasing recognition that brain and body are dynamically coupled has enriched our scientific understanding of mental health conditions. Peripheral signals interact centrally to influence how we think and feel, generating our sense of the internal condition of the body, a process known as intero...

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Veröffentlicht in:	Trends in cognitive sciences Jg. 26; H. 6; S. 499 - 513
Hauptverfasser:	Nord, Camilla L., Garfinkel, Sarah N.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.06.2022
Schlagworte:	antidepressant Anxiety - therapy Awareness Brain emotion Emotions Humans inflammation Interoception Mental Health psychological therapy interoception emotion inflammation psychological therapy mental health antidepressant
ISSN:	1364-6613, 1879-307X, 1879-307X
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Abstract	An increasing recognition that brain and body are dynamically coupled has enriched our scientific understanding of mental health conditions. Peripheral signals interact centrally to influence how we think and feel, generating our sense of the internal condition of the body, a process known as interoception. Disruptions to this interoceptive system may contribute to clinical conditions, including anxiety, depression, and psychosis. After reviewing the nature of interoceptive disturbances in mental health conditions, this review focuses on interoceptive pathways of existing and putative mental health treatments. Emerging clinical interventions may target novel peripheral treatment mechanisms. Future treatment development requires forward- and back-translation to uncover and target specific interoceptive processes in mental health to elucidate their efficacy relative to interventions targeting other factors. Patients with neuropsychiatric disorders associated with altered emotional or physical experiences show disruptions in interoception.Interoception may be an important target of both existing and novel mental health treatments.Antidepressants modulate aspects of interoception and specific psychological therapies target interoceptive processes, particularly breathing.Medications for certain physical health conditions are associated with better mental health.Interoceptive measures could be used to stratify patients for treatment selection.
AbstractList	An increasing recognition that brain and body are dynamically coupled has enriched our scientific understanding of mental health conditions. Peripheral signals interact centrally to influence how we think and feel, generating our sense of the internal condition of the body, a process known as interoception. Disruptions to this interoceptive system may contribute to clinical conditions, including anxiety, depression, and psychosis. After reviewing the nature of interoceptive disturbances in mental health conditions, this review focuses on interoceptive pathways of existing and putative mental health treatments. Emerging clinical interventions may target novel peripheral treatment mechanisms. Future treatment development requires forward- and back-translation to uncover and target specific interoceptive processes in mental health to elucidate their efficacy relative to interventions targeting other factors.An increasing recognition that brain and body are dynamically coupled has enriched our scientific understanding of mental health conditions. Peripheral signals interact centrally to influence how we think and feel, generating our sense of the internal condition of the body, a process known as interoception. Disruptions to this interoceptive system may contribute to clinical conditions, including anxiety, depression, and psychosis. After reviewing the nature of interoceptive disturbances in mental health conditions, this review focuses on interoceptive pathways of existing and putative mental health treatments. Emerging clinical interventions may target novel peripheral treatment mechanisms. Future treatment development requires forward- and back-translation to uncover and target specific interoceptive processes in mental health to elucidate their efficacy relative to interventions targeting other factors. An increasing recognition that brain and body are dynamically coupled has enriched our scientific understanding of mental health conditions. Peripheral signals interact centrally to influence how we think and feel, generating our sense of the internal condition of the body, a process known as interoception. Disruptions to this interoceptive system may contribute to clinical conditions, including anxiety, depression, and psychosis. After reviewing the nature of interoceptive disturbances in mental health conditions, this review focuses on interoceptive pathways of existing and putative mental health treatments. Emerging clinical interventions may target novel peripheral treatment mechanisms. Future treatment development requires forward- and back-translation to uncover and target specific interoceptive processes in mental health to elucidate their efficacy relative to interventions targeting other factors. Patients with neuropsychiatric disorders associated with altered emotional or physical experiences show disruptions in interoception.Interoception may be an important target of both existing and novel mental health treatments.Antidepressants modulate aspects of interoception and specific psychological therapies target interoceptive processes, particularly breathing.Medications for certain physical health conditions are associated with better mental health.Interoceptive measures could be used to stratify patients for treatment selection. An increasing recognition that brain and body are dynamically coupled has enriched our scientific understanding of mental health conditions. Peripheral signals interact centrally to influence how we think and feel, generating our sense of the internal condition of the body, a process known as interoception. Disruptions to this interoceptive system may contribute to clinical conditions, including anxiety, depression, and psychosis. After reviewing the nature of interoceptive disturbances in mental health conditions, this review focuses on interoceptive pathways of existing and putative mental health treatments. Emerging clinical interventions may target novel peripheral treatment mechanisms. Future treatment development requires forward- and back-translation to uncover and target specific interoceptive processes in mental health to elucidate their efficacy relative to interventions targeting other factors.
Author	Nord, Camilla L. Garfinkel, Sarah N.
Author_xml	– sequence: 1 givenname: Camilla L. surname: Nord fullname: Nord, Camilla L. email: Camilla.Nord@mrc-cbu.cam.ac.uk organization: MRC Cognition and Brain Sciences Unit, 15 Chaucer Rd, Cambridge CB2 7EF, UK – sequence: 2 givenname: Sarah N. orcidid: 0000-0002-5961-1012 surname: Garfinkel fullname: Garfinkel, Sarah N. email: s.garfinkel@ucl.ac.uk organization: Institute of Cognitive Neuroscience, UCL, Alexandra House, 17-19 Queen Square, London WC1N 3AZ, UK
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Snippet	An increasing recognition that brain and body are dynamically coupled has enriched our scientific understanding of mental health conditions. Peripheral signals...
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SubjectTerms	antidepressant Anxiety - therapy Awareness Brain emotion Emotions Humans inflammation Interoception Mental Health psychological therapy
Title	Interoceptive pathways to understand and treat mental health conditions
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