CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPalpha, to inhibit phagocytosis of normal, healthy cells. We find that mobilizing cytokines and inflammatory stimuli cause CD47 to be transie...

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Bibliographic Details
Published in:	Cell Vol. 138; no. 2; p. 271
Main Authors:	Jaiswal, Siddhartha, Jamieson, Catriona H M, Pang, Wendy W, Park, Christopher Y, Chao, Mark P, Majeti, Ravindra, Traver, David, van Rooijen, Nico, Weissman, Irving L
Format:	Journal Article
Language:	English
Published:	United States 23.07.2009
Subjects:	Animals Antibodies, Monoclonal CD47 Antigen - immunology Cell Survival fms-Like Tyrosine Kinase 3 Hematopoietic Stem Cells - immunology Humans Macrophages - immunology Mice Neoplasm Transplantation Neoplastic Stem Cells - immunology Phagocytosis Protein-Tyrosine Kinases - chemistry Receptors, Immunologic Transplantation, Heterologous Up-Regulation
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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