RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement

V(D)J recombination of TCR loci is regulated by chromatin accessibility to RAG1/2 proteins, rendering RAG1/2 targeting a potentially important regulator of lymphoid differentiation. We show that within the human TCR-α/δ locus, Dδ2-Dδ3 rearrangements occur at a very immature thymic, CD34(+)/CD1a(-)/C...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 211; H. 9; S. 1821
Hauptverfasser:	Cieslak, Agata, Le Noir, Sandrine, Trinquand, Amélie, Lhermitte, Ludovic, Franchini, Don-Marc, Villarese, Patrick, Gon, Stéphanie, Bond, Jonathan, Simonin, Mathieu, Vanhille, Laurent, Vanhile, Laurent, Reimann, Christian, Verhoeyen, Els, Larghero, Jerome, Six, Emmanuelle, Spicuglia, Salvatore, André-Schmutz, Isabelle, Langerak, Anton, Nadel, Bertrand, Macintyre, Elizabeth, Payet-Bornet, Dominique, Asnafi, Vahid
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 25.08.2014
Schlagworte:	Animals Base Sequence Binding Sites - genetics Cell Differentiation Cell Line Core Binding Factor Alpha 2 Subunit - metabolism DNA - genetics DNA - metabolism Gene Rearrangement, delta-Chain T-Cell Antigen Receptor HEK293 Cells Homeodomain Proteins - metabolism Humans Kinetics Lymphopoiesis Mice Molecular Sequence Data Species Specificity T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism VDJ Recombinases - metabolism
ISSN:	1540-9538, 1540-9538
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