Molecular imaging by mass spectrometry — looking beyond classical histology

Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)? Imaging mass spectrometry (IMS) using matrix-assisted laser desorptio...

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Veröffentlicht in:	Nature reviews. Cancer Jg. 10; H. 9; S. 639 - 646
Hauptverfasser:	Schwamborn, Kristina, Caprioli, Richard M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.09.2010 Nature Publishing Group
Schlagworte:	631/1647/527/296 631/45/475 631/67/1857 692/700/1421/2160 Animals Biomedical and Life Sciences Biomedicine Cancer Cancer Research Diagnosis Diagnostic imaging Drug Discovery Humans innovation Innovations Mass spectrometry Methods Mice Neoplasms - chemistry Neoplasms - drug therapy Neoplasms - pathology Proteome - analysis Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Treatment Outcome United States
ISSN:	1474-175X, 1474-1768, 1474-1768
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Abstract	Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)? Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.
AbstractList	Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies. Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)? Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies. Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.
Audience	Academic
Author	Caprioli, Richard M. Schwamborn, Kristina
Author_xml	– sequence: 1 givenname: Kristina surname: Schwamborn fullname: Schwamborn, Kristina organization: Department of Biochemistry, Kristina Schwamborn and Richard M. Caprioli are at the Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37232-2195, USA – sequence: 2 givenname: Richard M. surname: Caprioli fullname: Caprioli, Richard M. email: richard.m.caprioli@vanderbilt.edu organization: Department of Biochemistry, Kristina Schwamborn and Richard M. Caprioli are at the Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37232-2195, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/20720571$$D View this record in MEDLINE/PubMed
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Snippet	Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass... Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex...
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SubjectTerms	631/1647/527/296 631/45/475 631/67/1857 692/700/1421/2160 Animals Biomedical and Life Sciences Biomedicine Cancer Cancer Research Diagnosis Diagnostic imaging Drug Discovery Humans innovation Innovations Mass spectrometry Methods Mice Neoplasms - chemistry Neoplasms - drug therapy Neoplasms - pathology Proteome - analysis Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Treatment Outcome
Title	Molecular imaging by mass spectrometry — looking beyond classical histology
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