Molecular imaging by mass spectrometry — looking beyond classical histology

Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)? Imaging mass spectrometry (IMS) using matrix-assisted laser desorptio...

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Vydáno v:Nature reviews. Cancer Ročník 10; číslo 9; s. 639 - 646
Hlavní autoři: Schwamborn, Kristina, Caprioli, Richard M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.09.2010
Nature Publishing Group
Témata:
631/1647/527/296
631/45/475
631/67/1857
692/700/1421/2160
Animals
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Diagnosis
Diagnostic imaging
Drug Discovery
Humans
innovation
Innovations
Mass spectrometry
Methods
Mice
Neoplasms - chemistry
Neoplasms - drug therapy
Neoplasms - pathology
Proteome - analysis
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
Treatment Outcome
United States
ISSN:1474-175X, 1474-1768, 1474-1768
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Abstract Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)? Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.
AbstractList Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.
Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)? Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.
Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.
Audience Academic
Author Caprioli, Richard M.
Schwamborn, Kristina
Author_xml – sequence: 1
  givenname: Kristina
  surname: Schwamborn
  fullname: Schwamborn, Kristina
  organization: Department of Biochemistry, Kristina Schwamborn and Richard M. Caprioli are at the Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37232-2195, USA
– sequence: 2
  givenname: Richard M.
  surname: Caprioli
  fullname: Caprioli, Richard M.
  email: richard.m.caprioli@vanderbilt.edu
  organization: Department of Biochemistry, Kristina Schwamborn and Richard M. Caprioli are at the Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37232-2195, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20720571$$D View this record in MEDLINE/PubMed
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Snippet Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass...
Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex...
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SubjectTerms 631/1647/527/296
631/45/475
631/67/1857
692/700/1421/2160
Animals
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Diagnosis
Diagnostic imaging
Drug Discovery
Humans
innovation
Innovations
Mass spectrometry
Methods
Mice
Neoplasms - chemistry
Neoplasms - drug therapy
Neoplasms - pathology
Proteome - analysis
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
Treatment Outcome
Title Molecular imaging by mass spectrometry — looking beyond classical histology
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