Molecular imaging by mass spectrometry — looking beyond classical histology

Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)? Imaging mass spectrometry (IMS) using matrix-assisted laser desorptio...

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Bibliographic Details
Published in:Nature reviews. Cancer Vol. 10; no. 9; pp. 639 - 646
Main Authors: Schwamborn, Kristina, Caprioli, Richard M.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.09.2010
Nature Publishing Group
Subjects:
631/1647/527/296
631/45/475
631/67/1857
692/700/1421/2160
Animals
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Diagnosis
Diagnostic imaging
Drug Discovery
Humans
innovation
Innovations
Mass spectrometry
Methods
Mice
Neoplasms - chemistry
Neoplasms - drug therapy
Neoplasms - pathology
Proteome - analysis
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
Treatment Outcome
United States
ISSN:1474-175X, 1474-1768, 1474-1768
Online Access:Get full text
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Summary:Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)? Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.
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ISSN:1474-175X
1474-1768
1474-1768
DOI:10.1038/nrc2917