The Warburg effect then and now: From cancer to inflammatory diseases

Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, a phenomenon known as the Warburg effect. The result of this change in macrophages is to...

Full description

Saved in:

Bibliographic Details
Published in:	BioEssays Vol. 35; no. 11; pp. 965 - 973
Main Authors:	Palsson-McDermott, Eva M., O'Neill, Luke A. J.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01.11.2013 Wiley Subscription Services, Inc
Subjects:	AMP-Activated Protein Kinases - metabolism Animals Biosynthesis Carrier Proteins - metabolism Cell Line, Tumor Cell Proliferation Citric Acid - metabolism Citric Acid Cycle - physiology Dendritic Cells - metabolism glycolysis Glycolysis - physiology Hexokinase - metabolism Hif-1α Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunity, Innate inflammation Inflammation - immunology Inflammation - pathology Lipopolysaccharides - metabolism Macrophages - metabolism Medical research Membrane Proteins - metabolism Metabolic disorders Metabolic Networks and Pathways - physiology metabolism Mitochondria - metabolism Neoplasms - immunology Neoplasms - pathology Oxidative Phosphorylation PKM2 Protein Serine-Threonine Kinases - metabolism Pyruvate Dehydrogenase Acetyl-Transferring Kinase Succinic Acid - metabolism Thyroid Hormone-Binding Proteins Thyroid Hormones - metabolism TLR Transcription Factors - metabolism Warburg effect PKM2 inflammation glycolysis metabolism Hif-1α TLR Warburg effect
ISSN:	0265-9247, 1521-1878, 1521-1878
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!