The Warburg effect then and now: From cancer to inflammatory diseases

Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, a phenomenon known as the Warburg effect. The result of this change in macrophages is to...

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Vydáno v:BioEssays Ročník 35; číslo 11; s. 965 - 973
Hlavní autoři: Palsson-McDermott, Eva M., O'Neill, Luke A. J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Blackwell Publishing Ltd 01.11.2013
Wiley Subscription Services, Inc
Témata:
AMP-Activated Protein Kinases - metabolism
Animals
Biosynthesis
Carrier Proteins - metabolism
Cell Line, Tumor
Cell Proliferation
Citric Acid - metabolism
Citric Acid Cycle - physiology
Dendritic Cells - metabolism
glycolysis
Glycolysis - physiology
Hexokinase - metabolism
Hif-1α
Humans
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Immunity, Innate
inflammation
Inflammation - immunology
Inflammation - pathology
Lipopolysaccharides - metabolism
Macrophages - metabolism
Medical research
Membrane Proteins - metabolism
Metabolic disorders
Metabolic Networks and Pathways - physiology
metabolism
Mitochondria - metabolism
Neoplasms - immunology
Neoplasms - pathology
Oxidative Phosphorylation
PKM2
Protein Serine-Threonine Kinases - metabolism
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
Succinic Acid - metabolism
Thyroid Hormone-Binding Proteins
Thyroid Hormones - metabolism
TLR
Transcription Factors - metabolism
Warburg effect
PKM2
inflammation
glycolysis
metabolism
Hif-1α
TLR
Warburg effect
ISSN:0265-9247, 1521-1878, 1521-1878
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Popis
Shrnutí:Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, a phenomenon known as the Warburg effect. The result of this change in macrophages is to rapidly provide ATP and metabolic intermediates for the biosynthesis of immune and inflammatory proteins. In addition, a rise in certain tricarboxylic acid cycle intermediates occurs notably in citrate for lipid biosynthesis, and succinate, which activates the transcription factor Hypoxia‐inducible factor. In this review we take a look at the emerging evidence for a role for the Warburg effect in the immune and inflammatory responses. The reprogramming of metabolic pathways in macrophages, dendritic cells, and T cells could have relevance in the pathogenesis of inflammatory and metabolic diseases and might provide novel therapeutic strategies. Recent studies reveal that inflammatory cells, when activated, display similar metabolic traits as cancer cells. During an inflammatory response or infection pro‐inflammatory immune cells can shift their metabolism away from oxidative phosphorylation towards a high rate of glycolysis, a phenomenon known as the Warburg effect.
Bibliografie:istex:AAA005EE560A52ADD87595EF574D926B4FEAD2F2
ark:/67375/WNG-WZWKLX6D-8
ArticleID:BIES201300084
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
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ISSN:0265-9247
1521-1878
1521-1878
DOI:10.1002/bies.201300084