Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon

Most viruses have acquired mechanisms to suppress antiviral alpha/beta interferon (IFN-α/β) and stress responses. Enteroviruses (EVs) actively counteract the induction of IFN-α/β gene transcription and stress granule (SG) formation, which are increasingly implicated as a platform for antiviral signa...

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Vydáno v:	Journal of virology Ročník 93; číslo 10
Hlavní autoři:	Visser, Linda J, Langereis, Martijn A, Rabouw, Huib H, Wahedi, Maryam, Muntjewerff, Elke M, de Groot, Raoul J, van Kuppeveld, Frank J M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.05.2019
Témata:	Antigens, Viral - metabolism Antiviral Agents - pharmacology Cell Line Cysteine Endopeptidases - metabolism Cytoplasmic Granules - metabolism Cytoplasmic Granules - virology Encephalomyocarditis virus - genetics Enterovirus - metabolism Enterovirus A, Human - genetics Enterovirus A, Human - metabolism Enterovirus A, Human - pathogenicity Enterovirus B, Human - genetics Enterovirus Infections - virology HeLa Cells Host-Pathogen Interactions - drug effects Humans Immune Evasion - drug effects Interferon Type I - metabolism Interferon-beta - metabolism Peptide Hydrolases - metabolism Phosphorylation Proteolysis Signal Transduction - drug effects Stress, Physiological - physiology Viral Proteins - metabolism CV-A21 EV-A71 2Apro 3Cpro enterovirus EV-D68 stress granules CV-B3 type I IFN SGs
ISSN:	1098-5514, 1098-5514
On-line přístup:	Zjistit podrobnosti o přístupu
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