Human haematopoietic stem cell development: from the embryo to the dish

Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult haematopoietic system. Understanding how early haematopoietic development occurs is of fundamental importance for basic biology and medical sciences, but our knowledge is still limited compared with what we know...

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Bibliographic Details
Published in:Development (Cambridge) Vol. 144; no. 13; p. 2323
Main Authors: Ivanovs, Andrejs, Rybtsov, Stanislav, Ng, Elizabeth S, Stanley, Edouard G, Elefanty, Andrew G, Medvinsky, Alexander
Format: Journal Article
Language:English
Published: England 01.07.2017
Subjects:
Embryo Culture Techniques - methods
Embryo, Mammalian - cytology
Hematopoiesis
Hematopoietic Stem Cells - cytology
Humans
Phenotype
Regeneration
Human
hPSC
HSC
Embryo
Reprogramming
ISSN:1477-9129, 1477-9129
Online Access:Get more information
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Summary:Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult haematopoietic system. Understanding how early haematopoietic development occurs is of fundamental importance for basic biology and medical sciences, but our knowledge is still limited compared with what we know of adult HSCs and their microenvironment. This is particularly true for human haematopoiesis, and is reflected in our current inability to recapitulate the development of HSCs from pluripotent stem cells In this Review, we discuss what is known of human haematopoietic development: the anatomical sites at which it occurs, the different temporal waves of haematopoiesis, the emergence of the first HSCs and the signalling landscape of the haematopoietic niche. We also discuss the extent to which differentiation of human pluripotent stem cells recapitulates bona fide human developmental haematopoiesis, and outline some future directions in the field.
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ISSN:1477-9129
1477-9129
DOI:10.1242/dev.134866