Influenza and Bacterial Superinfection: Illuminating the Immunologic Mechanisms of Disease

Seasonal influenza virus infection presents a major strain on the health care system. Influenza virus infection has pandemic potential, which was repeatedly observed during the last century. Severe disease may occur in the young, in the elderly, in those with preexisting lung disease, and in previou...

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Vydané v:	Infection and immunity Ročník 83; číslo 10; s. 3764
Hlavní autori:	Rynda-Apple, Agnieszka, Robinson, Keven M, Alcorn, John F
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.10.2015
Predmet:	Animals Humans Influenza A virus - physiology Influenza, Human - complications Influenza, Human - virology Staphylococcal Infections - immunology Staphylococcal Infections - microbiology Staphylococcus aureus - physiology Streptococcus pneumoniae - physiology Superinfection - immunology Superinfection - microbiology
ISSN:	1098-5522, 1098-5522
On-line prístup:	Zistit podrobnosti o prístupe
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Abstract	Seasonal influenza virus infection presents a major strain on the health care system. Influenza virus infection has pandemic potential, which was repeatedly observed during the last century. Severe disease may occur in the young, in the elderly, in those with preexisting lung disease, and in previously healthy individuals. A common cause of severe influenza pathogenesis is superinfection with bacterial pathogens, namely, Staphylococcus aureus and Streptococcus pneumoniae. A great deal of recent research has focused on the immune pathways involved in influenza-induced susceptibility to secondary bacterial pneumonia. Both innate and adaptive antibacterial host defenses are impaired in the context of preceding influenza virus infection. The goal of this minireview is to highlight these findings and synthesize these data into a shared central theme of pathogenesis.
AbstractList	Seasonal influenza virus infection presents a major strain on the health care system. Influenza virus infection has pandemic potential, which was repeatedly observed during the last century. Severe disease may occur in the young, in the elderly, in those with preexisting lung disease, and in previously healthy individuals. A common cause of severe influenza pathogenesis is superinfection with bacterial pathogens, namely, Staphylococcus aureus and Streptococcus pneumoniae. A great deal of recent research has focused on the immune pathways involved in influenza-induced susceptibility to secondary bacterial pneumonia. Both innate and adaptive antibacterial host defenses are impaired in the context of preceding influenza virus infection. The goal of this minireview is to highlight these findings and synthesize these data into a shared central theme of pathogenesis. Seasonal influenza virus infection presents a major strain on the health care system. Influenza virus infection has pandemic potential, which was repeatedly observed during the last century. Severe disease may occur in the young, in the elderly, in those with preexisting lung disease, and in previously healthy individuals. A common cause of severe influenza pathogenesis is superinfection with bacterial pathogens, namely, Staphylococcus aureus and Streptococcus pneumoniae. A great deal of recent research has focused on the immune pathways involved in influenza-induced susceptibility to secondary bacterial pneumonia. Both innate and adaptive antibacterial host defenses are impaired in the context of preceding influenza virus infection. The goal of this minireview is to highlight these findings and synthesize these data into a shared central theme of pathogenesis.Seasonal influenza virus infection presents a major strain on the health care system. Influenza virus infection has pandemic potential, which was repeatedly observed during the last century. Severe disease may occur in the young, in the elderly, in those with preexisting lung disease, and in previously healthy individuals. A common cause of severe influenza pathogenesis is superinfection with bacterial pathogens, namely, Staphylococcus aureus and Streptococcus pneumoniae. A great deal of recent research has focused on the immune pathways involved in influenza-induced susceptibility to secondary bacterial pneumonia. Both innate and adaptive antibacterial host defenses are impaired in the context of preceding influenza virus infection. The goal of this minireview is to highlight these findings and synthesize these data into a shared central theme of pathogenesis.
Author	Robinson, Keven M Alcorn, John F Rynda-Apple, Agnieszka
Author_xml	– sequence: 1 givenname: Agnieszka surname: Rynda-Apple fullname: Rynda-Apple, Agnieszka organization: Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA – sequence: 2 givenname: Keven M surname: Robinson fullname: Robinson, Keven M organization: Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA – sequence: 3 givenname: John F surname: Alcorn fullname: Alcorn, John F email: john.alcorn@chp.edu organization: Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA john.alcorn@chp.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26216421$$D View this record in MEDLINE/PubMed
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PublicationYear	2015
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Snippet	Seasonal influenza virus infection presents a major strain on the health care system. Influenza virus infection has pandemic potential, which was repeatedly...
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SubjectTerms	Animals Humans Influenza A virus - physiology Influenza, Human - complications Influenza, Human - virology Staphylococcal Infections - immunology Staphylococcal Infections - microbiology Staphylococcus aureus - physiology Streptococcus pneumoniae - physiology Superinfection - immunology Superinfection - microbiology
Title	Influenza and Bacterial Superinfection: Illuminating the Immunologic Mechanisms of Disease
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