An Outcomes-Based Definition of Proteinuria Remission in Focal Segmental Glomerulosclerosis

Proteinuria is used as an indicator of FSGS disease activity, but its use as a clinical trial end point is not universally accepted. The goal of this study was to refine proteinuria definitions associated with long-term kidney survival. Data on 466 patients with primary FSGS with proteinuria (urine...

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Veröffentlicht in:	Clinical journal of the American Society of Nephrology Jg. 13; H. 3; S. 414
Hauptverfasser:	Troost, Jonathan P, Trachtman, Howard, Nachman, Patrick H, Kretzler, Matthias, Spino, Cathie, Komers, Radko, Tuller, Sarah, Perumal, Kalyani, Massengill, Susan F, Kamil, Elaine S, Oh, Gia, Selewski, David T, Gipson, Patrick, Gipson, Debbie S
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 07.03.2018
Schlagworte:	Adolescent Adult Biomarkers - urine Child Creatinine - urine Disease Progression Endpoint Determination Female Glomerular Filtration Rate Glomerulosclerosis, Focal Segmental - complications Glomerulosclerosis, Focal Segmental - drug therapy Glomerulosclerosis, Focal Segmental - physiopathology Glomerulosclerosis, Focal Segmental - urine Humans Kaplan-Meier Estimate Kidney Failure, Chronic - etiology Kidney Failure, Chronic - urine Male Middle Aged Observational Studies as Topic Prognosis Proportional Hazards Models Proteinuria - etiology Proteinuria - urine Randomized Controlled Trials as Topic ROC Curve Treatment Outcome Young Adult Prognosis glomerular filtration rate Humans proteinuria Proportional Hazards Models surrogate endpoint Propensity Score kidney creatinine Renal Insufficiency FSGS Kidney Failure, Chronic Glomerulosclerosis, Focal Segmental Goals Cohort Studies
ISSN:	1555-905X, 1555-905X
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