Red Blood Cell-Mediated S-Nitrosohemoglobin-Dependent Vasodilation: Lessons Learned from a β-Globin Cys93 Knock-In Mouse

Red blood cell (RBC)-mediated vasodilation plays an important role in oxygen delivery. This occurs through hemoglobin actions, at least in significant part, to convert heme-bound nitric oxide (NO) (in tense [T]/deoxygenated-state hemoglobin) into vasodilator S-nitrosothiol (SNO) (in relaxed [R]/oxyg...

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Bibliographic Details
Published in:	Antioxidants & redox signaling Vol. 34; no. 12; p. 936
Main Authors:	Premont, Richard T, Reynolds, James D, Zhang, Rongli, Stamler, Jonathan S
Format:	Journal Article
Language:	English
Published:	United States 20.04.2021
Subjects:	Animals beta-Globins - genetics beta-Globins - metabolism Erythrocytes - metabolism Erythrocytes - pathology Gene Knock-In Techniques Hemoglobins - genetics Hemoglobins - metabolism Humans Mice Nitric Oxide - genetics Oxygen - metabolism S-Nitrosothiols - therapeutic use Vasodilation - genetics S-nitrosohemoglobin S-nitrosothiol autoregulation hypoxic vasodilation S-nitrosylation
ISSN:	1557-7716, 1557-7716
Online Access:	Get more information
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