Impact of Asparaginase Discontinuation on Outcome in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group

Asparaginase (ASNase) is an important component of acute lymphoblastic leukemia (ALL) treatment, but is often discontinued because of toxicity. ASNase ( ) substitution was approved in 2011 for allergic reactions. has, however, been intermittently unavailable because of drug supply issues. The impact...

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Bibliographic Details
Published in:	Journal of clinical oncology Vol. 38; no. 17; p. 1897
Main Authors:	Gupta, Sumit, Wang, Cindy, Raetz, Elizabeth A, Schore, Reuven, Salzer, Wanda L, Larsen, Eric C, Maloney, Kelly W, Mattano, Jr, Len A, Carroll, William L, Winick, Naomi J, Hunger, Stephen P, Loh, Mignon L, Devidas, Meenakshi
Format:	Journal Article
Language:	English
Published:	United States 10.06.2020
Subjects:	Adolescent Asparaginase - administration & dosage Asparaginase - adverse effects Asparaginase - supply & distribution Child Child, Preschool Disease-Free Survival Erwinia - enzymology Female Humans Infant Male Polyethylene Glycols - administration & dosage Polyethylene Glycols - adverse effects Polyethylene Glycols - supply & distribution Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Prognosis Randomized Controlled Trials as Topic Substance Withdrawal Syndrome - etiology Treatment Outcome
ISSN:	1527-7755, 1527-7755
Online Access:	Get more information
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