Impact of Asparaginase Discontinuation on Outcome in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group

Asparaginase (ASNase) is an important component of acute lymphoblastic leukemia (ALL) treatment, but is often discontinued because of toxicity. ASNase ( ) substitution was approved in 2011 for allergic reactions. has, however, been intermittently unavailable because of drug supply issues. The impact...

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Veröffentlicht in:	Journal of clinical oncology Jg. 38; H. 17; S. 1897
Hauptverfasser:	Gupta, Sumit, Wang, Cindy, Raetz, Elizabeth A, Schore, Reuven, Salzer, Wanda L, Larsen, Eric C, Maloney, Kelly W, Mattano, Jr, Len A, Carroll, William L, Winick, Naomi J, Hunger, Stephen P, Loh, Mignon L, Devidas, Meenakshi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 10.06.2020
Schlagworte:	Adolescent Asparaginase - administration & dosage Asparaginase - adverse effects Asparaginase - supply & distribution Child Child, Preschool Disease-Free Survival Erwinia - enzymology Female Humans Infant Male Polyethylene Glycols - administration & dosage Polyethylene Glycols - adverse effects Polyethylene Glycols - supply & distribution Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Prognosis Randomized Controlled Trials as Topic Substance Withdrawal Syndrome - etiology Treatment Outcome
ISSN:	1527-7755, 1527-7755
Online-Zugang:	Weitere Angaben
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