The many faces of the anti-COVID immune response

The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are curre...

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Vydané v:The Journal of experimental medicine Ročník 217; číslo 6
Hlavní autori: Vardhana, Santosha A, Wolchok, Jedd D
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.06.2020
Predmet:
Adaptive Immunity - drug effects
Adaptive Immunity - immunology
Betacoronavirus - drug effects
Betacoronavirus - immunology
Betacoronavirus - pathogenicity
Coronavirus Infections - immunology
Coronavirus Infections - pathology
Coronavirus Infections - therapy
COVID-19
Cytokine Release Syndrome - immunology
Cytokine Release Syndrome - pathology
Cytokine Release Syndrome - therapy
Humans
Hypoxia - pathology
Hypoxia - therapy
Immunity, Innate - drug effects
Immunity, Innate - immunology
Inflammation - immunology
Inflammation - pathology
Inflammation - therapy
Interleukin-6 - antagonists & inhibitors
Interleukin-6 - immunology
Lymphopenia - immunology
Lymphopenia - pathology
Lymphopenia - therapy
Macrophages - immunology
Macrophages - pathology
Middle East Respiratory Syndrome Coronavirus - immunology
Middle East Respiratory Syndrome Coronavirus - pathogenicity
Pandemics
Pneumonia, Viral - immunology
Pneumonia, Viral - pathology
Pneumonia, Viral - therapy
Respiration, Artificial
Respiratory Distress Syndrome - pathology
Respiratory Distress Syndrome - therapy
SARS-CoV-2
Severe acute respiratory syndrome-related coronavirus - immunology
Severe acute respiratory syndrome-related coronavirus - pathogenicity
ISSN:1540-9538, 1540-9538
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Popis
Shrnutí:The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1540-9538
1540-9538
DOI:10.1084/jem.20200678