Potential pitfalls in skin permeation experiments: Influence of experimental factors and subsequent data evaluation

There is a growing demand for skin penetration and permeation data considering toxicological and potential drug delivery aspects for an increasing number of substances. Although there are official guidelines available, results from different skin diffusion studies are often inconsistent and sometime...

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Bibliographic Details
Published in:	European journal of pharmaceutics and biopharmaceutics Vol. 72; no. 2; pp. 324 - 331
Main Authors:	Henning, Andreas, Schaefer, Ulrich F., Neumann, Dirk
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01.06.2009 Elsevier
Subjects:	Algorithms Biological and medical sciences Diffusion General pharmacology Human skin preparation Humans Lag-time Linear Models Medical sciences Modelling Permeability Permeation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Skin Absorption Temperature Unstirred water layer Lag-time Temperature D Permeation MW D app UWL BSA OECD Human skin preparation t lag HSA Unstirred water layer Modelling PSA Water Human Evaluation Pharmaceutical technology Modeling Preparation Skin
ISSN:	0939-6411, 1873-3441, 1873-3441
Online Access:	Get full text
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