Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia

Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied donor weight loss. Furthermore, muscle wasting correlated with mortality and murine IL-6, and human IL-6 associated with the grea...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 218; H. 6
Hauptverfasser:	Rupert, Joseph E, Narasimhan, Ashok, Jengelley, Daenique H A, Jiang, Yanlin, Liu, Jianguo, Au, Ernie, Silverman, Libbie M, Sandusky, George, Bonetto, Andrea, Cao, Sha, Lu, Xiaoyu, O'Connell, Thomas M, Liu, Yunlong, Koniaris, Leonidas G, Zimmers, Teresa A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 07.06.2021
Schlagworte:	3T3 Cells Adenocarcinoma - metabolism Adenocarcinoma - pathology Adipocytes - metabolism Adipose Tissue - metabolism Adipose Tissue - pathology Aged Aged, 80 and over Animals Cachexia - metabolism Cachexia - pathology Cell Line Cell Line, Tumor Disease Models, Animal Female Humans Interleukin-6 - metabolism Lipolysis - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - pathology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Signal Transduction - physiology
ISSN:	1540-9538, 1540-9538
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