Real-Time Genome Sequencing of Resistant Bacteria Provides Precision Infection Control in an Institutional Setting

The increasing prevalence of multidrug-resistant (MDR) bacteria is a serious global challenge. Here, we studied prospectively whether bacterial whole-genome sequencing (WGS) for real-time MDR surveillance is technical feasible, returns actionable results, and is cost-beneficial. WGS was applied to a...

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Bibliographic Details
Published in:	Journal of clinical microbiology Vol. 54; no. 12; p. 2874
Main Authors:	Mellmann, Alexander, Bletz, Stefan, Böking, Thomas, Kipp, Frank, Becker, Karsten, Schultes, Anja, Prior, Karola, Harmsen, Dag
Format:	Journal Article
Language:	English
Published:	United States 01.12.2016
Subjects:	Anti-Bacterial Agents - pharmacology Cefotaxime - pharmacology Ciprofloxacin - pharmacology Cross Infection - microbiology Cross Infection - transmission Enterococcus faecium - drug effects Enterococcus faecium - genetics Enterococcus faecium - isolation & purification Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - isolation & purification Escherichia coli Infections - transmission Genome, Bacterial - genetics Gram-Positive Bacterial Infections - transmission High-Throughput Nucleotide Sequencing Humans Infection Control - methods Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - isolation & purification Microbial Sensitivity Tests Piperacillin - pharmacology Prospective Studies Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - transmission Sequence Analysis, DNA Staphylococcal Infections - transmission Vancomycin-Resistant Enterococci - drug effects Vancomycin-Resistant Enterococci - genetics Vancomycin-Resistant Enterococci - isolation & purification
ISSN:	1098-660X, 1098-660X
Online Access:	Get more information
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