Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis

Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hematopoiesis of indeterminate potential (CHIP). Analy...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 218; no. 12
Main Authors:	Kim, Peter Geon, Niroula, Abhishek, Shkolnik, Veronica, McConkey, Marie, Lin, Amy E, Słabicki, Mikołaj, Kemp, John P, Bick, Alexander, Gibson, Christopher J, Griffin, Gabriel, Sekar, Aswin, Brooks, Daniel J, Wong, Waihay J, Cohen, Drew N, Uddin, Md Mesbah, Shin, Wesley J, Pirruccello, James, Tsai, Jonathan M, Agrawal, Mridul, Kiel, Douglas P, Bouxsein, Mary L, Richards, J Brent, Evans, David M, Wein, Marc N, Charles, Julia F, Jaiswal, Siddhartha, Natarajan, Pradeep, Ebert, Benjamin L
Format:	Journal Article
Language:	English
Published:	United States 06.12.2021
Subjects:	Adult Aged Alendronate - pharmacology Animals Antibodies, Neutralizing - pharmacology Cell Differentiation - genetics Clonal Hematopoiesis - genetics Clonal Hematopoiesis - physiology DNA Methyltransferase 3A - genetics DNA Methyltransferase 3A - metabolism Female Humans Interleukins - immunology Interleukins - metabolism Male Mice Mice, Knockout Middle Aged Osteoclasts - pathology Osteoporosis - blood Osteoporosis - drug therapy Osteoporosis - genetics Osteoporosis - physiopathology
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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