Neutrophil phenotypes and functions in cancer: A consensus statement
Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however,...
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| Vydáno v: | The Journal of experimental medicine Ročník 219; číslo 6 |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
06.06.2022
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| ISSN: | 1540-9538, 1540-9538 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
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| Abstract | Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer. |
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| AbstractList | Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer. Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer. |
| Author | Huttenlocher, Anna Pittet, Mikael J Fridlender, Zvi G Aziz, Monowar Malanchi, Ilaria Granot, Zvi de Visser, Karin E Barnes, Betsy J Zychlinsky, Arturo Meylan, Etienne Mittal, Vivek van den Berg, Timo K Kubes, Paul Eruslanov, Evgeniy Amulic, Borko Hidalgo, Andrés Udalova, Irina A Wang, Ping Merghoub, Taha Goodridge, Helen S Wagner, Denisa D Quail, Daniela F Kaplan, Mariana J Rubio-Ponce, Andrea Egeblad, Mikala |
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Evgeniy organization: Division of Thoracic Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA – sequence: 6 givenname: Zvi G orcidid: 0000-0002-6122-1988 surname: Fridlender fullname: Fridlender, Zvi G organization: Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel – sequence: 7 givenname: Helen S orcidid: 0000-0001-8097-2413 surname: Goodridge fullname: Goodridge, Helen S organization: Board of Governors Regenerative Medicine Institute and Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA – sequence: 8 givenname: Zvi orcidid: 0000-0001-9692-5785 surname: Granot fullname: Granot, Zvi organization: Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem, Jerusalem, Israel – sequence: 9 givenname: Andrés orcidid: 0000-0001-5513-555X surname: Hidalgo fullname: Hidalgo, Andrés organization: Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain – sequence: 10 givenname: Anna orcidid: 0000-0001-7940-6254 surname: Huttenlocher fullname: Huttenlocher, Anna organization: Department of Pediatrics, University of Wisconsin-Madison, Madison, WI – sequence: 11 givenname: Mariana J orcidid: 0000-0003-2968-0815 surname: Kaplan fullname: Kaplan, Mariana J organization: Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD – sequence: 12 givenname: Ilaria orcidid: 0000-0003-4867-3311 surname: Malanchi fullname: Malanchi, Ilaria organization: Tumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK – sequence: 13 givenname: Taha orcidid: 0000-0002-1518-5111 surname: Merghoub fullname: Merghoub, Taha organization: Weill Cornell Medical College, New York, NY – sequence: 14 givenname: Etienne orcidid: 0000-0002-0899-2230 surname: Meylan fullname: Meylan, Etienne organization: Laboratory of Immunobiology, Université Libre de Bruxelles, Gosselies, Belgium – sequence: 15 givenname: Vivek orcidid: 0000-0002-4764-7413 surname: Mittal fullname: Mittal, Vivek organization: Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY – sequence: 16 givenname: Mikael J orcidid: 0000-0002-2060-4691 surname: Pittet fullname: Pittet, Mikael J organization: AGORA Cancer Research Center, Lausanne, Switzerland – sequence: 17 givenname: Andrea orcidid: 0000-0002-4275-8835 surname: Rubio-Ponce fullname: Rubio-Ponce, Andrea organization: Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain – sequence: 18 givenname: Irina A orcidid: 0000-0002-6716-2528 surname: Udalova fullname: Udalova, Irina A organization: University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK – sequence: 19 givenname: Timo K orcidid: 0000-0002-2052-3904 surname: van den Berg fullname: van den Berg, Timo K organization: Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam, Netherlands – sequence: 20 givenname: Denisa D orcidid: 0000-0002-4494-413X surname: Wagner fullname: Wagner, Denisa D organization: Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA – sequence: 21 givenname: Ping orcidid: 0000-0002-1557-0394 surname: Wang fullname: Wang, Ping organization: Center for Immunology and Inflammation, Feinstein Institutes for Medical Research, Manhasset, NY – sequence: 22 givenname: Arturo orcidid: 0000-0001-6018-193X surname: Zychlinsky fullname: Zychlinsky, Arturo organization: Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany – sequence: 23 givenname: Karin E orcidid: 0000-0002-0293-868X surname: de Visser fullname: de Visser, Karin E organization: Banbury Center meeting organizers, Diverse Functions of Neutrophils in Cancer, Cold Spring Harbor Laboratory, New York, NY – sequence: 24 givenname: Mikala orcidid: 0000-0002-3371-1445 surname: Egeblad fullname: Egeblad, Mikala organization: Banbury Center meeting organizers, Diverse Functions of Neutrophils in Cancer, Cold Spring Harbor Laboratory, New York, NY – sequence: 25 givenname: Paul orcidid: 0000-0002-2835-4244 surname: Kubes fullname: Kubes, Paul organization: Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada |
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| Snippet | Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of... |
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| SubjectTerms | Humans Immunity, Innate Inflammation Neoplasms - genetics Neutrophils Phenotype |
| Title | Neutrophil phenotypes and functions in cancer: A consensus statement |
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| Volume | 219 |
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