Glucocorticoids unmask silent non-coding genetic risk variants for common diseases

Understanding the function of non-coding genomic sequence variants represents a challenge for biomedicine. Many diseases are products of gene-by-environment interactions with complex mechanisms. This study addresses these themes by mechanistic characterization of non-coding variants that influence g...

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Vydáno v:	Nucleic acids research Ročník 50; číslo 20; s. 11635 - 11653
Hlavní autoři:	Nguyen, Thanh Thanh L, Gao, Huanyao, Liu, Duan, Philips, Trudy Janice, Ye, Zhenqing, Lee, Jeong-Heon, Shi, Geng-xian, Copenhaver, Kaleigh, Zhang, Lingxin, Wei, Lixuan, Yu, Jia, Zhang, Huan, Barath, Abhijeet, Luong, Maggie, Zhang, Cheng, Gaspar-Maia, Alexandre, Li, Hu, Wang, Liewei, Ordog, Tamas, Weinshilboum, Richard M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Oxford University Press 11.11.2022
Témata:	Genomics Glucocorticoids - genetics Glucocorticoids - metabolism Humans Pharmacogenetics Quantitative Trait Loci Regulatory Sequences, Nucleic Acid Risk Factors
ISSN:	0305-1048, 1362-4962, 1362-4962
On-line přístup:	Získat plný text
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