ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus

Cells sense pathogen-derived double-stranded RNA (dsRNA) as nonself. To avoid autoimmune activation by self dsRNA, cells utilize A-to-I editing by adenosine deaminase acting on RNA 1 (ADAR1) to disrupt dsRNA structures. Considering that viruses have evolved to exploit host machinery, A-to-I editing...

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Veröffentlicht in:	Journal of virology Jg. 94; H. 6
Hauptverfasser:	Yanai, Mako, Kojima, Shohei, Sakai, Madoka, Komorizono, Ryo, Tomonaga, Keizo, Makino, Akiko
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 28.02.2020
Schlagworte:	A-to-I editing nuclear-replicating RNA virus innate immunity persistent infection self/nonself
ISSN:	1098-5514, 1098-5514
Online-Zugang:	Weitere Angaben
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