Evaluation of T-cell responses to novel RD1- and RD2-encoded Mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection

The tuberculin skin test for diagnosing Mycobacterium tuberculosis infection suffers from antigenic cross-reactivity of purified protein derivative with BCG, resulting in poor specificity in BCG-vaccinated populations. Comparative genomics has identified several genetic regions in M. tuberculosis an...

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Veröffentlicht in:	Infection and immunity Jg. 72; H. 5; S. 2574
Hauptverfasser:	Liu, Xiao-Qing, Dosanjh, Davinder, Varia, Hansa, Ewer, Katie, Cockle, Paul, Pasvol, Geoffrey, Lalvani, Ajit
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.05.2004
Schlagworte:	Adolescent Adult Aged Amino Acid Sequence Antigens, Bacterial - genetics Bacterial Proteins - genetics Bacterial Proteins - immunology BCG Vaccine - immunology Case-Control Studies Cross Reactions Female Genes, Bacterial Humans In Vitro Techniques Interferon-gamma - biosynthesis Male Middle Aged Molecular Sequence Data Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Prospective Studies Sensitivity and Specificity T-Lymphocytes - immunology Tuberculosis - diagnosis Tuberculosis - immunology Tuberculosis - microbiology
ISSN:	0019-9567
Online-Zugang:	Weitere Angaben
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