Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

We have generated mouse models of malignant mesothelioma (MM) based upon disruption of the Bap1, Nf2, and Cdkn2ab tumor suppressor loci in various combinations as also frequently observed in human MM. Inactivation of all three loci in the mesothelial lining of the thoracic cavity leads to a highly a...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 217; no. 6
Main Authors:	Badhai, Jitendra, Pandey, Gaurav Kumar, Song, Ji-Ying, Krijgsman, Oscar, Bhaskaran, Rajith, Chandrasekaran, Gayathri, Kwon, Min-Chul, Bombardelli, Lorenzo, Monkhorst, Kim, Grasso, Cristoforo, Zevenhoven, John, van der Vliet, Jan, Cozijnsen, Miranda, Krimpenfort, Paul, Peeper, Daniel, van Lohuizen, Maarten, Berns, Anton
Format:	Journal Article
Language:	English
Published:	United States 01.06.2020
Subjects:	Animals Cyclin-Dependent Kinase Inhibitor p15 - metabolism Cyclin-Dependent Kinase Inhibitor p16 - metabolism Disease Models, Animal Disease Progression Gene Deletion Humans Immunophenotyping MAP Kinase Signaling System - drug effects Mesothelioma, Malignant - genetics Mesothelioma, Malignant - metabolism Mesothelioma, Malignant - pathology Mice Neurofibromin 2 - metabolism Phosphatidylinositol 3-Kinases - metabolism Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Protein Kinase Inhibitors - pharmacology Transcription, Genetic - drug effects Tumor Microenvironment - drug effects Tumor Suppressor Proteins - metabolism Ubiquitin Thiolesterase - metabolism
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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