Identification and genetic diversity of two human parvovirus B19 genotype 3 subtypes

Three genotypes (1-3) of human parvovirus B19 have been identified. Analysis of 13 nearly full-length genotype 3 sequences from Ghana, Europe and Brazil identified two genetically distinct clusters. The classification of genotype 3 strains into two subtypes (B19/3a and B19/3b) is proposed. The rate...

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Vydáno v:Journal of general virology Ročník 88; číslo Pt 2; s. 428
Hlavní autoři: Parsyan, Armen, Szmaragd, Camille, Allain, Jean-Pierre, Candotti, Daniel
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 01.02.2007
Témata:
Brazil - epidemiology
DNA, Viral - analysis
Europe - epidemiology
Genetic Variation
Genotype
Ghana - epidemiology
Humans
Molecular Sequence Data
Parvoviridae Infections - epidemiology
Parvoviridae Infections - virology
Parvovirus B19, Human - classification
Parvovirus B19, Human - genetics
Phylogeny
Sequence Analysis, DNA
Brazil
Europe
Ghana
ISSN:0022-1317
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Shrnutí:Three genotypes (1-3) of human parvovirus B19 have been identified. Analysis of 13 nearly full-length genotype 3 sequences from Ghana, Europe and Brazil identified two genetically distinct clusters. The classification of genotype 3 strains into two subtypes (B19/3a and B19/3b) is proposed. The rate of evolutionary change of B19 genotype 3 strains (2 x 10(-4) nucleotide substitutions per site per year) was similar to those of B19 genotype 1 and carnivore parvoviruses, supporting the hypothesis that high mutation rates are characteristic of members of the family Parvoviridae. The estimated divergence time between B19/3a and B19/3b is 525 years. In Ghana, subtype B19/3a is predominant.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-1317
DOI:10.1099/vir.0.82496-0