ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina

To evaluate the retinal phenotype of 7- and 14-month-old apoB100,LDLR-/- mice, a relevant animal model of lipid metabolism dysfunction. Single-flash electroretinograms were obtained from 7- and 14-month-old apoB100,LDLR-/- and control mice fed a standard diet under both scotopic and photopic conditi...

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Veröffentlicht in:	Investigative ophthalmology & visual science Jg. 49; H. 4; S. 1307
Hauptverfasser:	Bretillon, Lionel, Acar, Niyazi, Seeliger, Mathias W, Santos, Mylène, Maire, Marie Annick, Juanéda, Pierre, Martine, Lucy, Grégoire, Stéphane, Joffre, Corinne, Bron, Alain M, Creuzot-Garcher, Catherine
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2008
Schlagworte:	Animals Apolipoprotein B-100 - physiology Basement Membrane - metabolism Cholesterol Esters - metabolism Dark Adaptation Electroretinography Female Filipin - metabolism Fluorescein Angiography Lipid Metabolism Disorders - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Ophthalmoscopy Photic Stimulation Pigment Epithelium of Eye - metabolism Receptors, LDL - physiology Retina - metabolism Retinal Diseases - metabolism Retinal Diseases - pathology Retinoids - metabolism
ISSN:	0146-0404
Online-Zugang:	Weitere Angaben
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