TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy

Background: Tumour-specific radiosensitising treatments may enhance the efficacy of radiotherapy without exacerbating side effects. In this study we determined the radiation response following depletion or inhibition of TOPK, a mitogen-activated protein kinase kinase family Ser/Thr protein kinase th...

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Bibliographic Details
Published in:	British journal of cancer Vol. 117; no. 4; pp. 503 - 512
Main Authors:	Pirovano, Giacomo, Ashton, Thomas M, Herbert, Katharine J, Bryant, Richard J, Verrill, Clare L, Cerundolo, Lucia, Buffa, Francesca M, Prevo, Remko, Harrap, Iona, Ryan, Anderson J, Macaulay, Valentine, McKenna, William G, Higgins, Geoff S
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.08.2017 Nature Publishing Group
Subjects:	631/45/607/275 692/4028/67/589/466 692/699/67/1059/485 Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Biomedical and Life Sciences Biomedicine Cancer Research Cell cycle Cell Cycle Checkpoints - drug effects Cell Cycle Checkpoints - genetics Cell Cycle Checkpoints - radiation effects Cell death Cell Line, Tumor Cell Nucleus - genetics Cell Nucleus - radiation effects Chromosome aberrations Chromosome Aberrations - drug effects Chromosome Aberrations - radiation effects DNA damage Drug Resistance Epidemiology Gene Knockdown Techniques HCT116 Cells HeLa Cells Humans Kinases Male MAP kinase Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Molecular Medicine Neoplasm Recurrence, Local - metabolism Oncology Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - radiotherapy Protein kinase Protein Kinase Inhibitors - pharmacology Proteins Quinolones - pharmacology Radiation therapy Radiation Tolerance - drug effects Radiation Tolerance - genetics Radiosensitivity Side effects Survival Rate Translational Therapeutics Tumor cell lines Tumors PBK TOPK cancer radiosensitivity
ISSN:	0007-0920, 1532-1827, 1532-1827
Online Access:	Get full text
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