Thyroid Hormones Are Transport Substrates and Transcriptional Regulators of Organic Anion Transporting Polypeptide 2B1

Levothyroxine replacement therapy forms the cornerstone of hypothyroidism management. Variability in levothyroxine oral absorption may contribute to the well-recognized large interpatient differences in required dose. Moreover, levothyroxine-drug pharmacokinetic interactions are thought to be caused...

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Bibliographic Details
Published in:	Molecular pharmacology Vol. 94; no. 1; p. 700
Main Authors:	Meyer Zu Schwabedissen, Henriette E, Ferreira, Celio, Schaefer, Anima M, Oufir, Mouhssin, Seibert, Isabell, Hamburger, Matthias, Tirona, Rommel G
Format:	Journal Article
Language:	English
Published:	United States 01.07.2018
Subjects:	Animals Atorvastatin - pharmacology Biological Transport - drug effects Biological Transport - physiology Caco-2 Cells Cell Line Cell Line, Tumor Dogs Drug Interactions - physiology Estrone - analogs & derivatives Estrone - pharmacology Genes, Reporter - drug effects Genes, Reporter - physiology HeLa Cells Hep G2 Cells Humans Intestinal Absorption - drug effects Intestinal Absorption - physiology Madin Darby Canine Kidney Cells Organic Anion Transporters - antagonists & inhibitors Organic Anion Transporters - metabolism Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - physiology Thyroid Hormones - metabolism Transcription, Genetic - drug effects Transcription, Genetic - physiology
ISSN:	1521-0111, 1521-0111
Online Access:	Get more information
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