Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently inhibits ROCK1 and ROCK2 kinases that regulate the actomyosin cytoskeleton. We previously reported that ROCK kinase expression increases with huma...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 78; H. 12; S. 3321
Hauptverfasser:	Rath, Nicola, Munro, June, Cutiongco, Marie Francene, Jagiełło, Alicja, Gadegaard, Nikolaj, McGarry, Lynn, Unbekandt, Mathieu, Michalopoulou, Evdokia, Kamphorst, Jurre J, Sumpton, David, Mackay, Gillian, Vennin, Claire, Pajic, Marina, Timpson, Paul, Olson, Michael F
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.06.2018
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 2-Hydroxyphenethylamine - analogs & derivatives 2-Hydroxyphenethylamine - pharmacology 2-Hydroxyphenethylamine - therapeutic use Amides - pharmacology Amides - therapeutic use Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor - transplantation Cell Movement - drug effects Disease Models, Animal Female HEK293 Cells Humans Male Mice Neoplasm Invasiveness - pathology Neoplasm Invasiveness - prevention & control Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Pyrazoles - pharmacology Pyrazoles - therapeutic use Pyridines - pharmacology Pyridines - therapeutic use rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Signal Transduction - drug effects
ISSN:	1538-7445, 1538-7445
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