Antimicrobial Resistance in ESKAPE Pathogens

Antimicrobial-resistant ESKAPE ( , , , , , and species) pathogens represent a global threat to human health. The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due...

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Bibliographic Details
Published in:Clinical microbiology reviews Vol. 33; no. 3
Main Authors: De Oliveira, David M P, Forde, Brian M, Kidd, Timothy J, Harris, Patrick N A, Schembri, Mark A, Beatson, Scott A, Paterson, David L, Walker, Mark J
Format: Journal Article
Language:English
Published: United States 17.06.2020
Subjects:
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacteria - genetics
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Drug Discovery
Drug Resistance, Multiple, Bacterial
Humans
Enterococcus
Klebsiella
multidrug resistance
Enterobacter
Enterobacterales
antibiotic resistance
Acinetobacter
Pseudomonas aeruginosa
Staphylococcus aureus
ISSN:1098-6618, 1098-6618
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Summary:Antimicrobial-resistant ESKAPE ( , , , , , and species) pathogens represent a global threat to human health. The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antimicrobial resistance surveillance. This looming health threat has restimulated interest in the development of new antimicrobial therapies, has demanded the need for better patient care, and has facilitated heightened governance over stewardship practices.
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ISSN:1098-6618
1098-6618
DOI:10.1128/CMR.00181-19