Phylogeny and evolutionary genetics of porcine parvovirus in wild boars

► Genetic diversity and evolution of porcine parvovirus in wild boars were studied. ► PPVs of wild boars proved to be more diverse than viruses of domestic pigs. ► High rate of evolution for VP1/VP2 genes was found. ► PPV has a relatively recent evolutionary history, diverged in the last 20–60years....

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Published in:Infection, genetics and evolution Vol. 12; no. 6; pp. 1163 - 1171
Main Authors: Cadar, Dániel, Dán, Ádám, Tombácz, Kata, Lőrincz, Márta, Kiss, Timea, Becskei, Zsolt, Spînu, Marina, Tuboly, Tamás, Cságola, Attila
Format: Journal Article
Language:English
Published: Kidlington Elsevier B.V 01.08.2012
Elsevier
Subjects:
Animals
Antigens, Viral
Antigens, Viral - genetics
Biological and medical sciences
Capsid Proteins
Capsid Proteins - genetics
classification
DNA Mutational Analysis
DNA, Viral
Epidemiology. Vaccinations
Evolution
Evolution, Molecular
fetal death
General aspects
Genetic diversity
genetics
Infectious diseases
Kidney
Kidney - virology
Liver
Liver - virology
Lung
Lung - virology
Lymphoid Tissue
Lymphoid Tissue - virology
Medical sciences
Parvovirus, Porcine
Parvovirus, Porcine - classification
Parvovirus, Porcine - genetics
Phylogeny
Polymerase Chain Reaction
Porcine parvovirus
PPV
Prevalence
Romania
sequence analysis
sows
Sus scrofa
Sus scrofa - virology
Ungulate protoparvovirus 1
vaccination
virology
viruses
Wild boar
wild boars
Romania
Evolution
Genetic diversity
Phylogeny
PPV
Wild boar
Virus
Infection
Parvovirus
Parvoviridae
Molecular epidemiology
Parvovirinae
Porcine parvovirus
ISSN:1567-1348, 1567-7257, 1567-7257
Online Access:Get full text
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Summary:► Genetic diversity and evolution of porcine parvovirus in wild boars were studied. ► PPVs of wild boars proved to be more diverse than viruses of domestic pigs. ► High rate of evolution for VP1/VP2 genes was found. ► PPV has a relatively recent evolutionary history, diverged in the last 20–60years. Porcine parvovirus (PPV) is widespread among swine and is responsible for reproductive failure of susceptible sows, characterized by embryonic and fetal death. Studies showed that PPV in domestic pig is genetically diverse and some strains differ from the ones used for vaccination. Organ samples from wild boars and domestic pigs were collected in Transylvania (Romania) and tested for the presence of PPV by polymerase chain reaction. Positive samples were grouped and 14 from the wild boar and 1 from the domestic pig PPVs were selected for VP1/VP2 sequence analysis and comparison with available GenBank data. The molecular clock analysis revealed that PPV has a relatively recent evolutionary history, originated approximately 120years ago and the main divergence occurred in the last 20–60years. Phylogenetic and residue substitution analysis showed that the viruses could be divided into 6 distinct clusters and that wild boar PPVs were partially different and independent from domestic pig PPVs. PPVs of wild boars proved to be more diverse than viruses of domestic pigs. The presence of the highly virulent 27a-like PPV strains in wild boars was also detected.
Bibliography:http://dx.doi.org/10.1016/j.meegid.2012.04.020
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ISSN:1567-1348
1567-7257
1567-7257
DOI:10.1016/j.meegid.2012.04.020