Pediatric brain natriuretic peptide and N-terminal pro-brain natriuretic peptide reference intervals

Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) have been shown to be useful biomarkers for the diagnosis of heart failure. Pediatric reference intervals for these analytes have been reported in part. Previous studies lack large numbers in each group, have no...

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Veröffentlicht in:Clinica chimica acta Jg. 366; H. 1; S. 304 - 308
Hauptverfasser: Soldin, Steven J., Soldin, Offie P., Boyajian, Alanna J., Taskier, Madeline S.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.04.2006
Schlagworte:
Adolescent
Adult
Age Factors
BNP
Chemistry Techniques, Analytical - instrumentation
Chemistry Techniques, Analytical - methods
Child
Child, Preschool
Creatine Kinase, MB Form - blood
Female
Humans
Infant
Infant, Newborn
Male
Natriuretic Peptide, Brain - blood
NT-proBNP
Pediatric reference intervals
Peptide Fragments - blood
Reference Values
Reproducibility of Results
Troponin - blood
Pediatric reference intervals
BNP
NT-proBNP
ISSN:0009-8981, 1873-3492
Online-Zugang:Volltext
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Zusammenfassung:Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) have been shown to be useful biomarkers for the diagnosis of heart failure. Pediatric reference intervals for these analytes have been reported in part. Previous studies lack large numbers in each group, have not covered all age ranges and have not compared results for BNP with NT-proBNP in simultaneously drawn samples. We measured BNP in whole blood using the Biosite Triage point-of-care method and plasma NT-proBNP using the Dade RxL Dimension. We assessed between and within-day precision of both methods and after removing outliers employed the Hoffmann approach to calculate pediatric reference intervals over the age range of 0–21 y. We also compared the 2 methods on simultaneously drawn samples. Reference intervals revealed approximately 20-fold higher 97.5th percentiles for neonates than for children > 3 y of age. 97.5th percentiles decreased significantly over the first 3 years of life. As shown by others, the CVs for the automated Dade RxL platform were somewhat lower than those for the POCT method. BNP and NT-proBNP correlated well in simultaneously drawn samples ( r = 0.947). Reference intervals for BNP and NT-proBNP are far higher in neonates and infants than in children older than three years of age. The reasons for this are unknown but resemble the elevated CK-MBs and troponins also found in neonates, although the 97.5th percentiles for these latter 2 cardiac markers decrease more rapidly to values found in older children by 6 months of age.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2005.11.005