Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population

To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not as...

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Vydané v:European journal of human genetics : EJHG Ročník 16; číslo 6; s. 762 - 765
Hlavní autori: Blanton, Ronald E, Silva, Luciano K, Morato, Vanessa G, Parrado, Antonio R, Dias, Juarez P, Melo, Paulo R S, Reis, Eliana A G, Goddard, Katrina A B, Nunes, Márcio R T, Rodrigues, Sueli G, Vasconcelos, Pedro F C, Castro, Jesuina M, Reis, Mitermayer G, Barreto, Maurício L, Teixeira, M Glória
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Cham Springer International Publishing 01.06.2008
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Abstract To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF ( P =0.02, OR=0.28 and P =0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
AbstractList To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF ( P =0.02, OR=0.28 and P =0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P=0.02, OR=0.28 and P=0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P=0.02, OR=0.28 and P=0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P=0.02, OR=0.28 and P=0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
Author Dias, Juarez P
Castro, Jesuina M
Nunes, Márcio R T
Silva, Luciano K
Reis, Eliana A G
Blanton, Ronald E
Melo, Paulo R S
Vasconcelos, Pedro F C
Reis, Mitermayer G
Parrado, Antonio R
Rodrigues, Sueli G
Goddard, Katrina A B
Barreto, Maurício L
Teixeira, M Glória
Morato, Vanessa G
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Keywords ethnicity
race
population structure
DENV3
socioeconomic status
Hemorrhagic fever
Socioeconomic status
Dengue hemorrhagic fever
Dengue
Population structure
Ethnic group
Infection
Association
Viral disease
Arbovirus disease
Race
Genetics
Population
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TH Nguyen (BFejhg20084_CR7) 2005; 72
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Snippet To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293...
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SubjectTerms African Continental Ancestry Group - genetics
Arboviroses
Bioinformatics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brazil
Cytogenetics
Dengue - genetics
Dengue fever
Dengue fevers
Dengue hemorrhagic fever
Diagnosis
Disease
Epidemics
Epidemiology
Ethnic groups
Ethnicity
Fever
Fundamental and applied biological sciences. Psychology
Gene Expression
General aspects. Genetic counseling
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genotype
Human Genetics
Human viral diseases
Humans
Income
Infectious diseases
Laboratories
Medical genetics
Medical sciences
Minority & ethnic groups
Molecular and cellular biology
Population
short-report
Single-nucleotide polymorphism
Socioeconomic factors
Tropical viral diseases
Viral diseases
Title Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
URI https://link.springer.com/article/10.1038/ejhg.2008.4
https://www.ncbi.nlm.nih.gov/pubmed/18270538
https://www.proquest.com/docview/217844426
https://www.proquest.com/docview/20902726
https://www.proquest.com/docview/70764428
Volume 16
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