Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population

To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not as...

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Bibliographic Details
Published in:European journal of human genetics : EJHG Vol. 16; no. 6; pp. 762 - 765
Main Authors: Blanton, Ronald E, Silva, Luciano K, Morato, Vanessa G, Parrado, Antonio R, Dias, Juarez P, Melo, Paulo R S, Reis, Eliana A G, Goddard, Katrina A B, Nunes, Márcio R T, Rodrigues, Sueli G, Vasconcelos, Pedro F C, Castro, Jesuina M, Reis, Mitermayer G, Barreto, Maurício L, Teixeira, M Glória
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01.06.2008
Nature Publishing
Nature Publishing Group
Subjects:
African Continental Ancestry Group - genetics
Arboviroses
Bioinformatics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brazil
Cytogenetics
Dengue - genetics
Dengue fever
Dengue fevers
Dengue hemorrhagic fever
Diagnosis
Disease
Epidemics
Epidemiology
Ethnic groups
Ethnicity
Fever
Fundamental and applied biological sciences. Psychology
Gene Expression
General aspects. Genetic counseling
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genotype
Human Genetics
Human viral diseases
Humans
Income
Infectious diseases
Laboratories
Medical genetics
Medical sciences
Minority & ethnic groups
Molecular and cellular biology
Population
short-report
Single-nucleotide polymorphism
Socioeconomic factors
Tropical viral diseases
Viral diseases
Brazil
Haiti
Cleveland Ohio
United States > US
ethnicity
race
population structure
DENV3
socioeconomic status
Hemorrhagic fever
Socioeconomic status
Dengue hemorrhagic fever
Dengue
Population structure
Ethnic group
Infection
Association
Viral disease
Arbovirus disease
Race
Genetics
Population
ISSN:1018-4813, 1476-5438
Online Access:Get full text
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Summary:To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF ( P =0.02, OR=0.28 and P =0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
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ISSN:1018-4813
1476-5438
DOI:10.1038/ejhg.2008.4