Injectable Mussel‐Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration

In the early stage of osteoarthritis (OA), cartilage degradation in the surface region leads to superficial cartilage defect. However, enhancing the regeneration of cartilage defect remains a great challenge for existing hydrogel technology because of the weak adhesion to wet tissue. In the present...

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Vydané v:	Biomaterials Ročník 278; s. 121169
Hlavní autori:	Zhang, Fang-Xue, Liu, Peng, Ding, Wang, Meng, Qing-Bing, Su, Di-Han, Zhang, Qi-Chen, Lian, Rui-Xian, Yu, Bao-Qing, Zhao, Ming-Dong, Dong, Jian, Li, Yu-Lin, Jiang, Li-Bo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Elsevier Ltd 01.11.2021
Predmet:	adhesion Adhesive hydrogel arthroscopy biocompatible materials cartilage Cartilage defect Cell recruitment chemokines chondroitin sulfate crosslinking encapsulation Exosomes extracellular matrix fibroins gelation hydrogels inflation osteoarthritis rats shear strength Cell recruitment Adhesive hydrogel Exosomes Cartilage defect
ISSN:	0142-9612, 1878-5905, 1878-5905
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Abstract	In the early stage of osteoarthritis (OA), cartilage degradation in the surface region leads to superficial cartilage defect. However, enhancing the regeneration of cartilage defect remains a great challenge for existing hydrogel technology because of the weak adhesion to wet tissue. In the present study, an injectable mussel-inspired highly adhesive hydrogel with exosomes was investigated for endogenous cell recruitment and cartilage defect regeneration. The hydrogel with high bonding strength to the wet surface was prepared using a crosslinked network of alginate-dopamine, chondroitin sulfate, and regenerated silk fibroin (AD/CS/RSF). Compared with commercial enbucrilate tissue adhesive, the AD/CS/RSF hydrogel provided a comparative lap shear strength of 120 kPa, with a similar gelation time and a higher capacity for maintaining adhesive strength. The AD/CS/RSF/EXO hydrogel with encapsulated exosomes recruited BMSCs migration and inflation, promoted BMSCs proliferation and differentiation. Most importantly, the AD/CS/RSF/EXO hydrogel accelerated cartilage defect regeneration in situ, and extracellular matrix remodeling after injection in rat patellar grooves. The exosomes released by the hydrogels could recruit BMSCs into the hydrogel and neo-cartilage via the chemokine signaling pathway. Our findings reveal an injectable and adhesive hydrogel for superficial cartilage regeneration, which is a promising approach for minimally treating cartilage defect with arthroscopic assistance.
AbstractList	In the early stage of osteoarthritis (OA), cartilage degradation in the surface region leads to superficial cartilage defect. However, enhancing the regeneration of cartilage defect remains a great challenge for existing hydrogel technology because of the weak adhesion to wet tissue. In the present study, an injectable mussel-inspired highly adhesive hydrogel with exosomes was investigated for endogenous cell recruitment and cartilage defect regeneration. The hydrogel with high bonding strength to the wet surface was prepared using a crosslinked network of alginate-dopamine, chondroitin sulfate, and regenerated silk fibroin (AD/CS/RSF). Compared with commercial enbucrilate tissue adhesive, the AD/CS/RSF hydrogel provided a comparative lap shear strength of 120 kPa, with a similar gelation time and a higher capacity for maintaining adhesive strength. The AD/CS/RSF/EXO hydrogel with encapsulated exosomes recruited BMSCs migration and inflation, promoted BMSCs proliferation and differentiation. Most importantly, the AD/CS/RSF/EXO hydrogel accelerated cartilage defect regeneration in situ, and extracellular matrix remodeling after injection in rat patellar grooves. The exosomes released by the hydrogels could recruit BMSCs into the hydrogel and neo-cartilage via the chemokine signaling pathway. Our findings reveal an injectable and adhesive hydrogel for superficial cartilage regeneration, which is a promising approach for minimally treating cartilage defect with arthroscopic assistance. In the early stage of osteoarthritis (OA), cartilage degradation in the surface region leads to superficial cartilage defect. However, enhancing the regeneration of cartilage defect remains a great challenge for existing hydrogel technology because of the weak adhesion to wet tissue. In the present study, an injectable mussel-inspired highly adhesive hydrogel with exosomes was investigated for endogenous cell recruitment and cartilage defect regeneration. The hydrogel with high bonding strength to the wet surface was prepared using a crosslinked network of alginate-dopamine, chondroitin sulfate, and regenerated silk fibroin (AD/CS/RSF). Compared with commercial enbucrilate tissue adhesive, the AD/CS/RSF hydrogel provided a comparative lap shear strength of 120 kPa, with a similar gelation time and a higher capacity for maintaining adhesive strength. The AD/CS/RSF/EXO hydrogel with encapsulated exosomes recruited BMSCs migration and inflation, promoted BMSCs proliferation and differentiation. Most importantly, the AD/CS/RSF/EXO hydrogel accelerated cartilage defect regeneration in situ, and extracellular matrix remodeling after injection in rat patellar grooves. The exosomes released by the hydrogels could recruit BMSCs into the hydrogel and neo-cartilage via the chemokine signaling pathway. Our findings reveal an injectable and adhesive hydrogel for superficial cartilage regeneration, which is a promising approach for minimally treating cartilage defect with arthroscopic assistance.In the early stage of osteoarthritis (OA), cartilage degradation in the surface region leads to superficial cartilage defect. However, enhancing the regeneration of cartilage defect remains a great challenge for existing hydrogel technology because of the weak adhesion to wet tissue. In the present study, an injectable mussel-inspired highly adhesive hydrogel with exosomes was investigated for endogenous cell recruitment and cartilage defect regeneration. The hydrogel with high bonding strength to the wet surface was prepared using a crosslinked network of alginate-dopamine, chondroitin sulfate, and regenerated silk fibroin (AD/CS/RSF). Compared with commercial enbucrilate tissue adhesive, the AD/CS/RSF hydrogel provided a comparative lap shear strength of 120 kPa, with a similar gelation time and a higher capacity for maintaining adhesive strength. The AD/CS/RSF/EXO hydrogel with encapsulated exosomes recruited BMSCs migration and inflation, promoted BMSCs proliferation and differentiation. Most importantly, the AD/CS/RSF/EXO hydrogel accelerated cartilage defect regeneration in situ, and extracellular matrix remodeling after injection in rat patellar grooves. The exosomes released by the hydrogels could recruit BMSCs into the hydrogel and neo-cartilage via the chemokine signaling pathway. Our findings reveal an injectable and adhesive hydrogel for superficial cartilage regeneration, which is a promising approach for minimally treating cartilage defect with arthroscopic assistance. In the early stage of osteoarthritis (OA), cartilage degradation in the surface region leads to superficial cartilage defect. However, enhancing the regeneration of cartilage defect remains a great challenge for existing hydrogel technology because of the weak adhesion to wet tissue. In the present study, an injectable mussel-inspired highly adhesive hydrogel with exosomes was investigated for endogenous cell recruitment and cartilage defect regeneration. The hydrogel with high bonding strength to the wet surface was prepared using a crosslinked network of alginate-dopamine, chondroitin sulfate, and regenerated silk fibroin (AD/CS/RSF). Compared with commercial enbucrilate tissue adhesive, the AD/CS/RSF hydrogel provided a comparative lap shear strength of 120 kPa, with a similar gelation time and a higher capacity for maintaining adhesive strength. The AD/CS/RSF/EXO hydrogel with encapsulated exosomes recruited BMSCs migration and inflation, promoted BMSCs proliferation and differentiation. Most importantly, the AD/CS/RSF/EXO hydrogel accelerated cartilage defect regeneration in situ, and extracellular matrix remodeling after injection in rat patellar grooves. The exosomes released by the hydrogels could recruit BMSCs into the hydrogel and neo-cartilage via the chemokine signaling pathway. Our findings reveal an injectable and adhesive hydrogel for superficial cartilage regeneration, which is a promising approach for minimally treating cartilage defect with arthroscopic assistance.
ArticleNumber	121169
Author	Zhang, Fang-Xue Ding, Wang Lian, Rui-Xian Jiang, Li-Bo Yu, Bao-Qing Meng, Qing-Bing Dong, Jian Liu, Peng Su, Di-Han Zhao, Ming-Dong Li, Yu-Lin Zhang, Qi-Chen
Author_xml	– sequence: 1 givenname: Fang-Xue surname: Zhang fullname: Zhang, Fang-Xue organization: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China – sequence: 2 givenname: Peng surname: Liu fullname: Liu, Peng organization: Department of Orthopedic Surgery, Eastern Hospital, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610110, China – sequence: 3 givenname: Wang surname: Ding fullname: Ding, Wang organization: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China – sequence: 4 givenname: Qing-Bing surname: Meng fullname: Meng, Qing-Bing organization: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China – sequence: 5 givenname: Di-Han surname: Su fullname: Su, Di-Han organization: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China – sequence: 6 givenname: Qi-Chen orcidid: 0000-0001-8776-1766 surname: Zhang fullname: Zhang, Qi-Chen organization: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China – sequence: 7 givenname: Rui-Xian surname: Lian fullname: Lian, Rui-Xian organization: Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China – sequence: 8 givenname: Bao-Qing surname: Yu fullname: Yu, Bao-Qing organization: Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No.2800 gongwei road, China – sequence: 9 givenname: Ming-Dong orcidid: 0000-0001-8469-5150 surname: Zhao fullname: Zhao, Ming-Dong email: zhaonissan@163.com organization: Department of Orthopaedics, Jinshan Hospital, Fudan University, 201508, Shanghai, China – sequence: 10 givenname: Jian surname: Dong fullname: Dong, Jian email: dong.jian@zs-hospital.sh.cn organization: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China – sequence: 11 givenname: Yu-Lin surname: Li fullname: Li, Yu-Lin email: yulinli@ecust.edu.cn organization: Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China – sequence: 12 givenname: Li-Bo orcidid: 0000-0002-5082-1849 surname: Jiang fullname: Jiang, Li-Bo email: jiang.libo@zs-hospital.sh.cn organization: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
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Snippet	In the early stage of osteoarthritis (OA), cartilage degradation in the surface region leads to superficial cartilage defect. However, enhancing the...
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SubjectTerms	adhesion Adhesive hydrogel arthroscopy biocompatible materials cartilage Cartilage defect Cell recruitment chemokines chondroitin sulfate crosslinking encapsulation Exosomes extracellular matrix fibroins gelation hydrogels inflation osteoarthritis rats shear strength
Title	Injectable Mussel‐Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration
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