NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker

NFATc2 -rearranged sarcomas ( NFATc2 -Sarcomas) are infrequent round cell tumors characterized by EWSR1-NFATc2 fusions and FUS-NFATc2 fusions. Although our knowledge on these neoplasms has increased recently, novel diagnostic tools and more comprehensive series are still needed. Here, we describe th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Modern pathology Jg. 33; H. 10; S. 1930 - 1944
Hauptverfasser:	Perret, Raul, Escuriol, Julien, Velasco, Valérie, Mayeur, Laetitia, Soubeyran, Isabelle, Delfour, Christophe, Aubert, Sébastien, Polivka, Marc, Karanian, Marie, Meurgey, Alexandra, Le Guellec, Sophie, Weingertner, Noelle, Hoeller, Sylvia, Coindre, Jean-Michel, Larousserie, Frédérique, Pierron, Gaëlle, Tirode, Franck, Le Loarer, François
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.10.2020 Elsevier Limited Nature Publishing Group: Open Access Hybrid Model Option B
Schlagworte:	13/51 14/32 14/63 38/39 38/43 38/91 692/699/67/1344 692/699/67/1798 Adult Aged Aggrecan Aggrecans - metabolism Biomarkers, Tumor - metabolism Bone cancer Bone Neoplasms - diagnosis Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone tumors Cancer CD99 antigen Chemotherapy Chondrosarcoma Cytogenetics Desmin Female Femur FLI-1 protein Humans Ilium Immunohistochemistry Karyotypes Keratin Laboratory Medicine Life Sciences Male Medical diagnosis Medicine Medicine & Public Health Mesenchyme Middle Aged Neoplasia NFATC Transcription Factors - genetics Oncogene Fusion Oncogene Proteins, Fusion - genetics Osteoid Pathology Patients Pleomorphism Sarcoma Sarcoma - diagnosis Sarcoma - genetics Sarcoma - metabolism Soft tissues Stroma Surgery Tibia Tumor suppressor genes Tumors
ISSN:	0893-3952, 1530-0285, 1530-0285
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	NFATc2 -rearranged sarcomas ( NFATc2 -Sarcomas) are infrequent round cell tumors characterized by EWSR1-NFATc2 fusions and FUS-NFATc2 fusions. Although our knowledge on these neoplasms has increased recently, novel diagnostic tools and more comprehensive series are still needed. Here, we describe the features of a series of seven molecularly confirmed NFATc2 -Sarcomas ( EWSR1 - NFATc2 , n = 4; FUS - NFATc2 , n = 3) and demonstrate the utility of AGGRECAN immunohistochemistry for their identification. Patients were four males and three females, ranging in age from 19 to 66 years (median: 33). All were primary bone tumors (femur, n = 4; tibia, n = 2; ilium, n = 1), frequently infiltrating the surrounding soft tissues. Treatment often consisted of neoadjuvant chemotherapy and surgery. Follow-up was available for six patients (median 18 months, range 5–102 months), three patients died of disease and four patients are currently alive. Histologically, tumors consisted of monotonous round cells growing in lobules and sheets in variable amounts of fibrous to myxoid stroma. Other findings included spindle cells, corded and trabecular architecture, nuclear pleomorphism, cartilaginous differentiation, and osteoid-like matrix. Histological response to neoadjuvant chemotherapy was poor in all resection specimens available for review ( n = 4). Tumors were diffusely positive for AGGRECAN and CD99 (7/7), and a subset expressed Pan-Keratin (AE1-AE3; 3/6), S100 (2/6), BCOR (2/6), ETV-4 (2/5), WT1 (2/6), and ERG (2/5). Desmin, NKX3-1, and SATB2 were negative (0/6). Diffuse AGGRECAN staining was also seen in 8/129 round cell sarcomas used for comparison, including mesenchymal chondrosarcoma (7/26) and CIC -sarcoma (1/26). Array-CGH showed complex karyotypes with recurrent deletions of tumor suppressor genes ( CDKN2A/B, TUSC7, and DMD) in three FUS-NFATC2 cases and a simpler profile without homozygous losses in one EWSR1 - NFATc2 case. Segmental chromosomal gains covering the loci of the fusion genes were detected in both variants. Overall, our study confirms and expands previous observations on NFATc2 -sarcomas and supports that AGGRECAN is a useful biomarker of these tumors.
AbstractList	NFATc2 -rearranged sarcomas ( NFATc2 -Sarcomas) are infrequent round cell tumors characterized by EWSR1-NFATc2 fusions and FUS-NFATc2 fusions. Although our knowledge on these neoplasms has increased recently, novel diagnostic tools and more comprehensive series are still needed. Here, we describe the features of a series of seven molecularly confirmed NFATc2 -Sarcomas ( EWSR1 - NFATc2 , n = 4; FUS - NFATc2 , n = 3) and demonstrate the utility of AGGRECAN immunohistochemistry for their identification. Patients were four males and three females, ranging in age from 19 to 66 years (median: 33). All were primary bone tumors (femur, n = 4; tibia, n = 2; ilium, n = 1), frequently infiltrating the surrounding soft tissues. Treatment often consisted of neoadjuvant chemotherapy and surgery. Follow-up was available for six patients (median 18 months, range 5–102 months), three patients died of disease and four patients are currently alive. Histologically, tumors consisted of monotonous round cells growing in lobules and sheets in variable amounts of fibrous to myxoid stroma. Other findings included spindle cells, corded and trabecular architecture, nuclear pleomorphism, cartilaginous differentiation, and osteoid-like matrix. Histological response to neoadjuvant chemotherapy was poor in all resection specimens available for review ( n = 4). Tumors were diffusely positive for AGGRECAN and CD99 (7/7), and a subset expressed Pan-Keratin (AE1-AE3; 3/6), S100 (2/6), BCOR (2/6), ETV-4 (2/5), WT1 (2/6), and ERG (2/5). Desmin, NKX3-1, and SATB2 were negative (0/6). Diffuse AGGRECAN staining was also seen in 8/129 round cell sarcomas used for comparison, including mesenchymal chondrosarcoma (7/26) and CIC -sarcoma (1/26). Array-CGH showed complex karyotypes with recurrent deletions of tumor suppressor genes ( CDKN2A/B, TUSC7, and DMD) in three FUS-NFATC2 cases and a simpler profile without homozygous losses in one EWSR1 - NFATc2 case. Segmental chromosomal gains covering the loci of the fusion genes were detected in both variants. Overall, our study confirms and expands previous observations on NFATc2 -sarcomas and supports that AGGRECAN is a useful biomarker of these tumors. NFATc2-rearranged sarcomas (NFATc2-Sarcomas) are infrequent round cell tumors characterized by EWSR1-NFATc2 fusions and FUS-NFATc2 fusions. Although our knowledge on these neoplasms has increased recently, novel diagnostic tools and more comprehensive series are still needed. Here, we describe the features of a series of seven molecularly confirmed NFATc2-Sarcomas (EWSR1-NFATc2, n = 4; FUS-NFATc2, n = 3) and demonstrate the utility of AGGRECAN immunohistochemistry for their identification. Patients were four males and three females, ranging in age from 19 to 66 years (median: 33). All were primary bone tumors (femur, n = 4; tibia, n = 2; ilium, n = 1), frequently infiltrating the surrounding soft tissues. Treatment often consisted of neoadjuvant chemotherapy and surgery. Follow-up was available for six patients (median 18 months, range 5-102 months), three patients died of disease and four patients are currently alive. Histologically, tumors consisted of monotonous round cells growing in lobules and sheets in variable amounts of fibrous to myxoid stroma. Other findings included spindle cells, corded and trabecular architecture, nuclear pleomorphism, cartilaginous differentiation, and osteoid-like matrix. Histological response to neoadjuvant chemotherapy was poor in all resection specimens available for review (n = 4). Tumors were diffusely positive for AGGRECAN and CD99 (7/7), and a subset expressed Pan-Keratin (AE1-AE3; 3/6), S100 (2/6), BCOR (2/6), ETV-4 (2/5), WT1 (2/6), and ERG (2/5). Desmin, NKX3-1, and SATB2 were negative (0/6). Diffuse AGGRECAN staining was also seen in 8/129 round cell sarcomas used for comparison, including mesenchymal chondrosarcoma (7/26) and CIC-sarcoma (1/26). Array-CGH showed complex karyotypes with recurrent deletions of tumor suppressor genes (CDKN2A/B, TUSC7, and DMD) in three FUS-NFATC2 cases and a simpler profile without homozygous losses in one EWSR1-NFATc2 case. Segmental chromosomal gains covering the loci of the fusion genes were detected in both variants. Overall, our study confirms and expands previous observations on NFATc2-sarcomas and supports that AGGRECAN is a useful biomarker of these tumors.NFATc2-rearranged sarcomas (NFATc2-Sarcomas) are infrequent round cell tumors characterized by EWSR1-NFATc2 fusions and FUS-NFATc2 fusions. Although our knowledge on these neoplasms has increased recently, novel diagnostic tools and more comprehensive series are still needed. Here, we describe the features of a series of seven molecularly confirmed NFATc2-Sarcomas (EWSR1-NFATc2, n = 4; FUS-NFATc2, n = 3) and demonstrate the utility of AGGRECAN immunohistochemistry for their identification. Patients were four males and three females, ranging in age from 19 to 66 years (median: 33). All were primary bone tumors (femur, n = 4; tibia, n = 2; ilium, n = 1), frequently infiltrating the surrounding soft tissues. Treatment often consisted of neoadjuvant chemotherapy and surgery. Follow-up was available for six patients (median 18 months, range 5-102 months), three patients died of disease and four patients are currently alive. Histologically, tumors consisted of monotonous round cells growing in lobules and sheets in variable amounts of fibrous to myxoid stroma. Other findings included spindle cells, corded and trabecular architecture, nuclear pleomorphism, cartilaginous differentiation, and osteoid-like matrix. Histological response to neoadjuvant chemotherapy was poor in all resection specimens available for review (n = 4). Tumors were diffusely positive for AGGRECAN and CD99 (7/7), and a subset expressed Pan-Keratin (AE1-AE3; 3/6), S100 (2/6), BCOR (2/6), ETV-4 (2/5), WT1 (2/6), and ERG (2/5). Desmin, NKX3-1, and SATB2 were negative (0/6). Diffuse AGGRECAN staining was also seen in 8/129 round cell sarcomas used for comparison, including mesenchymal chondrosarcoma (7/26) and CIC-sarcoma (1/26). Array-CGH showed complex karyotypes with recurrent deletions of tumor suppressor genes (CDKN2A/B, TUSC7, and DMD) in three FUS-NFATC2 cases and a simpler profile without homozygous losses in one EWSR1-NFATc2 case. Segmental chromosomal gains covering the loci of the fusion genes were detected in both variants. Overall, our study confirms and expands previous observations on NFATc2-sarcomas and supports that AGGRECAN is a useful biomarker of these tumors. NFATc2-rearranged sarcomas (NFATc2-Sarcomas) are infrequent round cell tumors characterized by EWSR1-NFATc2 fusions and FUS-NFATc2 fusions. Although our knowledge on these neoplasms has increased recently, novel diagnostic tools and more comprehensive series are still needed. Here, we describe the features of a series of seven molecularly confirmed NFATc2-Sarcomas (EWSR1-NFATc2, n = 4; FUS-NFATc2, n = 3) and demonstrate the utility of AGGRECAN immunohistochemistry for their identification. Patients were four males and three females, ranging in age from 19 to 66 years (median: 33). All were primary bone tumors (femur, n = 4; tibia, n = 2; ilium, n = 1), frequently infiltrating the surrounding soft tissues. Treatment often consisted of neoadjuvant chemotherapy and surgery. Follow-up was available for six patients (median 18 months, range 5-102 months), three patients died of disease and four patients are currently alive. Histologically, tumors consisted of monotonous round cells growing in lobules and sheets in variable amounts of fibrous to myxoid stroma. Other findings included spindle cells, corded and trabecular architecture, nuclear pleomorphism, cartilaginous differentiation, and osteoid-like matrix. Histological response to neoadjuvant chemotherapy was poor in all resection specimens available for review (n = 4). Tumors were diffusely positive for AGGRECAN and CD99 (7/7), and a subset expressed Pan-Keratin (AE1-AE3; 3/6), S100 (2/6), BCOR (2/6), ETV-4 (2/5), WT1 (2/6), and ERG (2/5). Desmin, NKX3-1, and SATB2 were negative (0/6). Diffuse AGGRECAN staining was also seen in 8/129 round cell sarcomas used for comparison, including mesenchymal chondrosarcoma (7/26) and CIC-sarcoma (1/26). Array-CGH showed complex karyotypes with recurrent deletions of tumor suppressor genes (CDKN2A/B, TUSC7, and DMD) in three FUS-NFATC2 cases and a simpler profile without homozygous losses in one EWSR1-NFATc2 case. Segmental chromosomal gains covering the loci of the fusion genes were detected in both variants. Overall, our study confirms and expands previous observations on NFATc2-sarcomas and supports that AGGRECAN is a useful biomarker of these tumors.
Author	Coindre, Jean-Michel Le Loarer, François Meurgey, Alexandra Larousserie, Frédérique Pierron, Gaëlle Perret, Raul Hoeller, Sylvia Tirode, Franck Escuriol, Julien Soubeyran, Isabelle Velasco, Valérie Le Guellec, Sophie Mayeur, Laetitia Aubert, Sébastien Weingertner, Noelle Polivka, Marc Karanian, Marie Delfour, Christophe
Author_xml	– sequence: 1 givenname: Raul orcidid: 0000-0003-2698-0249 surname: Perret fullname: Perret, Raul email: r.perret@bordeaux.unicancer.fr organization: Department of Biopathology, Bergonie Institute – sequence: 2 givenname: Julien surname: Escuriol fullname: Escuriol, Julien organization: Department of Biopathology, Bergonie Institute, Bordeaux University – sequence: 3 givenname: Valérie surname: Velasco fullname: Velasco, Valérie organization: Department of Biopathology, Bergonie Institute – sequence: 4 givenname: Laetitia surname: Mayeur fullname: Mayeur, Laetitia organization: Department of Biopathology, Bergonie Institute – sequence: 5 givenname: Isabelle surname: Soubeyran fullname: Soubeyran, Isabelle organization: Department of Biopathology, Bergonie Institute, INSERM U1218, ACTION Unit – sequence: 6 givenname: Christophe surname: Delfour fullname: Delfour, Christophe organization: Department of Pathology, Montpellier University Hospital – sequence: 7 givenname: Sébastien surname: Aubert fullname: Aubert, Sébastien organization: Department of Pathology, Institut de Pathologie, Univ. Lille, CHU Lille – sequence: 8 givenname: Marc surname: Polivka fullname: Polivka, Marc organization: Department of Pathology, APHP, Hôpital Cochin, DMU Imagina, Université de Paris – sequence: 9 givenname: Marie surname: Karanian fullname: Karanian, Marie organization: Department of Pathology, Leon Berard Center, Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon – sequence: 10 givenname: Alexandra surname: Meurgey fullname: Meurgey, Alexandra organization: Department of Pathology, Leon Berard Center – sequence: 11 givenname: Sophie surname: Le Guellec fullname: Le Guellec, Sophie organization: Department of Pathology, Claudius Regaud Institute, Toulouse-Oncopole – sequence: 12 givenname: Noelle surname: Weingertner fullname: Weingertner, Noelle organization: Department of Pathology, Strasbourg Regional University Hospital (Hautepierre Hospital) – sequence: 13 givenname: Sylvia surname: Hoeller fullname: Hoeller, Sylvia organization: Department of Pathology, Hospital of the University of Basel – sequence: 14 givenname: Jean-Michel surname: Coindre fullname: Coindre, Jean-Michel organization: Department of Biopathology, Bergonie Institute, Bordeaux University – sequence: 15 givenname: Frédérique surname: Larousserie fullname: Larousserie, Frédérique organization: Department of Pathology, APHP-Cochin Hospital – sequence: 16 givenname: Gaëlle surname: Pierron fullname: Pierron, Gaëlle organization: Department of Tumor Biology, Curie Institute – sequence: 17 givenname: Franck orcidid: 0000-0003-4731-7817 surname: Tirode fullname: Tirode, Franck organization: Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon – sequence: 18 givenname: François orcidid: 0000-0001-8582-9819 surname: Le Loarer fullname: Le Loarer, François email: f.le-loarer@bordeaux.unicancer.fr organization: Department of Biopathology, Bergonie Institute, Bordeaux University, INSERM U1218, ACTION Unit
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32327700$$D View this record in MEDLINE/PubMed https://hal.science/hal-03882511$$DView record in HAL
BookMark	eNp9kl1v0zAUhi00xLrBD-AGWeIGpAX8lSbhLqq2DqkaEhrX1olz0nqkdrGTou5f8I9x1A2kSXDlr-d9j-3znpET5x0S8pqzD5zJ8mNUXBZVxgTLWK5Edv-MzHgu00qU-QmZsbKSmaxycUrOYrxjjKu8FC_IqRRSFAVjM_Lr5qq-NSILCCGAW2NLIwTjtxA_UdNbZ43fwbDxvV9bc0G3vkcz9hAuKLiWmsPg1-hwsIbGYWwP1He0oAYiRvrTDhuKe9uiMzgd1Mvl18tFfUMhUqDO77GnrYW183Ey2EL4juEled5BH_HVw3hOvl1d3i6us9WX5edFvcqMUtWQAXbKqKKt5i0zXZmrjoHBrmtwLkSaibzCrmorruZGGIlV0yBj2JgOTAGmkefk_dF3A73eBZuqH7QHq6_rlZ720g-XIud8zxP77sjugv8xYhz01kaDfQ8O_Ri1kJUqSyUqmdC3T9A7PwaXXqKFKnI2Na5M1JsHamy22P6p_9iYBBRHwAQfY8BOGzvAYL0bAthec6YnJ32MgE4R0FME9H1S8ifKR_P_acRRExObQhD-Xvrfot8jRcSe
CitedBy_id	crossref_primary_10_1007_s00428_024_03784_x crossref_primary_10_3390_genes14081580 crossref_primary_10_1016_j_humpath_2024_03_005 crossref_primary_10_1016_j_mpdhp_2022_09_003 crossref_primary_10_3389_fped_2025_1602157 crossref_primary_10_1111_his_14547 crossref_primary_10_1007_s00428_024_03979_2 crossref_primary_10_1016_j_jos_2022_02_009 crossref_primary_10_1097_PAS_0000000000001627 crossref_primary_10_1097_PAS_0000000000001748 crossref_primary_10_1111_his_14845 crossref_primary_10_1002_gcc_70083 crossref_primary_10_1111_pin_13135 crossref_primary_10_1111_his_14231 crossref_primary_10_1111_his_14314 crossref_primary_10_1016_j_path_2021_06_009 crossref_primary_10_1111_pin_13293 crossref_primary_10_1038_s41698_022_00307_2 crossref_primary_10_12998_wjcc_v12_i16_2887 crossref_primary_10_1097_PAS_0000000000002175 crossref_primary_10_1111_his_15066 crossref_primary_10_1186_s13000_024_01443_y crossref_primary_10_1016_j_path_2023_07_001 crossref_primary_10_1002_gcc_22999 crossref_primary_10_1007_s00292_021_00935_8 crossref_primary_10_1007_s00292_025_01426_w crossref_primary_10_1016_j_humpath_2024_01_007 crossref_primary_10_1016_j_path_2025_01_001 crossref_primary_10_1016_j_prp_2024_155406 crossref_primary_10_1136_jcp_2025_210045 crossref_primary_10_1016_j_hpr_2022_300680 crossref_primary_10_3390_diagnostics11040690 crossref_primary_10_1038_s41698_021_00177_0 crossref_primary_10_1016_j_soc_2022_03_001 crossref_primary_10_1002_gcc_23026 crossref_primary_10_3390_ijms231911007 crossref_primary_10_1016_j_pathol_2022_11_012 crossref_primary_10_3390_ijms24065934 crossref_primary_10_1111_his_14265 crossref_primary_10_1016_j_modpat_2025_100840 crossref_primary_10_3390_ijms232416196 crossref_primary_10_1007_s12105_021_01285_w crossref_primary_10_1038_s41572_022_00393_3 crossref_primary_10_1007_s00256_022_04244_w
Cites_doi	10.1002/pbc.23040 10.1038/s41572-018-0003-x 10.1097/PAS.0000000000000697 10.1200/JCO.2018.36.15_suppl.11543 10.1158/1078-0432.CCR-11-1610 10.1002/jemt.1070280603 10.1155/2019/9386390 10.1097/PAS.0000000000000846 10.1073/pnas.1320036110 10.1007/s00432-019-02895-2 10.7554/eLife.26733 10.18632/oncotarget.6937 10.1200/JCO.2000.18.1.4 10.1186/s40634-014-0008-7 10.1016/j.anndiagpath.2017.11.011 10.1016/j.humpath.2018.03.020 10.1038/nm1270 10.1038/s41379-019-0323-8 10.1038/nbt.3519 10.1038/sj.cr.7290106 10.1002/path.5053 10.1111/his.12281 10.1586/14737140.8.4.617 10.1038/modpathol.2017.185 10.1007/s00428-014-1613-7 10.18632/oncotarget.20098 10.1371/journal.pgen.1004475 10.1002/gcc.22240 10.1111/his.13689 10.1038/modpathol.3800036 10.1038/ng.2974 10.1158/0008-5472.CAN-09-1902 10.1038/modpathol.2012.97 10.1177/106689690501300106 10.1038/s41389-018-0101-3 10.1002/gcc.20819 10.1007/s13277-015-4414-y 10.1038/nri1632 10.1158/1078-0432.CCR-08-2184 10.1038/modpathol.2016.140 10.1007/s00428-012-1306-z 10.1016/j.ydbio.2007.12.014 10.1016/j.path.2017.04.002 10.1093/bioinformatics/btq170 10.1002/pbc.25210 10.1016/j.humpath.2019.05.001 10.1177/1066896919827093 10.1097/PAS.0000000000001441 10.1097/PAS.0000000000001260 10.1002/gcc.22763
ContentType	Journal Article
Copyright	The Author(s), under exclusive licence to United States & Canadian Academy of Pathology 2020 The Author(s), under exclusive licence to United States & Canadian Academy of Pathology 2020. Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml	– notice: The Author(s), under exclusive licence to United States & Canadian Academy of Pathology 2020 – notice: The Author(s), under exclusive licence to United States & Canadian Academy of Pathology 2020. – notice: Distributed under a Creative Commons Attribution 4.0 International License
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QP 7RV 7TK 7X7 7XB 88A 88E 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. KB0 LK8 M0S M1P M7P NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 1XC
DOI	10.1038/s41379-020-0542-z
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Nursing & Allied Health Database Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Biological Sciences ProQuest Health & Medical Collection Medical Database ProQuest Biological Science Database Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic Hyper Article en Ligne (HAL)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE ProQuest Central Student
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Biology
EISSN	1530-0285
EndPage	1944
ExternalDocumentID	oai:HAL:hal-03882511v1 32327700 10_1038_s41379_020_0542_z
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- -Q- .GJ 0R~ 123 29M 2WC 36B 39C 3V. 4.4 53G 5RE 70F 7RV 7X7 88A 88E 8AO 8FE 8FH 8FI 8FJ 8R4 8R5 AALRI AANZL AAQQT AASDW AAWTL AAXUO AAZLF ABAWZ ABJNI ABLJU ABUWG ACGFO ACGFS ACKTT ACPRK ACRQY ACZOJ ADBBV ADFRT ADHDB ADVLN AEJRE AENEX AEXYK AFJKZ AFKRA AFOSN AFSHS AGAYW AGHAI AHMBA AHSBF AILAN AITUG AJRNO AKRWK ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMRAJ AMYLF AXYYD BAWUL BBNVY BENPR BHPHI BKEYQ BKKNO BPHCQ BVXVI CAG CCPQU COF CS3 DIK DNIVK DU5 E3Z EBS EE. EIOEI EJD EX3 F5P FDB FDQFY FERAY FIZPM FSGXE FYUFA GX1 HCIFZ HMCUK HZ~ IWAJR JSO KQ8 LK8 M0L M1P M7P NAO NAPCQ NQJWS O9- OK1 OWW P2P PQQKQ PROAC PSQYO Q2X RNS RNT RNTTT ROL SNX SNYQT SOHCF SRMVM SWTZT TAOOD TBHMF TDRGL TR2 TSG UKHRP WOW YFH ZGI ZXP AAYWO AAYXX ACVFH ADCNI AEUPX AFFHD AFPUW AIGII AKBMS AKYEP APXCP CITATION EBLON EFKBS JZLTJ PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QP 7TK 7XB 8FK AZQEC DWQXO GNUQQ K9. PKEHL PQEST PQUKI PRINS 7X8 1XC
ID	FETCH-LOGICAL-c449t-aef4c47d96d0cf854f0aceffbe622ace259ef9d9146c2c3e9bbe00ebcfac7acb3
IEDL.DBID	7RV
ISICitedReferencesCount	43
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000528304300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0893-3952 1530-0285
IngestDate	Tue Oct 14 20:44:47 EDT 2025 Sun Nov 09 10:30:49 EST 2025 Fri Oct 03 08:32:09 EDT 2025 Thu Apr 03 07:03:42 EDT 2025 Sat Nov 29 03:42:46 EST 2025 Tue Nov 18 22:10:17 EST 2025 Fri Feb 21 02:39:42 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	10
Language	English
License	Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c449t-aef4c47d96d0cf854f0aceffbe622ace259ef9d9146c2c3e9bbe00ebcfac7acb3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0003-2698-0249 0000-0003-4731-7817 0000-0001-8582-9819
OpenAccessLink	http://mp.uscap.org/article/S089339522200463X/pdf
PMID	32327700
PQID	2475010388
PQPubID	33743
PageCount	15
ParticipantIDs	hal_primary_oai_HAL_hal_03882511v1 proquest_miscellaneous_2394884293 proquest_journals_2475010388 pubmed_primary_32327700 crossref_citationtrail_10_1038_s41379_020_0542_z crossref_primary_10_1038_s41379_020_0542_z springer_journals_10_1038_s41379_020_0542_z
PublicationCentury	2000
PublicationDate	20201000 2020-10-00 20201001 2020-10
PublicationDateYYYYMMDD	2020-10-01
PublicationDate_xml	– month: 10 year: 2020 text: 20201000
PublicationDecade	2020
PublicationPlace	New York
PublicationPlace_xml	– name: New York – name: United States – name: Kidlington
PublicationSubtitle	Publishing innovative clinical and translational research in the pathology of human disease
PublicationTitle	Modern pathology
PublicationTitleAbbrev	Mod Pathol
PublicationTitleAlternate	Mod Pathol
PublicationYear	2020
Publisher	Nature Publishing Group US Elsevier Limited Nature Publishing Group: Open Access Hybrid Model Option B
Publisher_xml	– name: Nature Publishing Group US – name: Elsevier Limited – name: Nature Publishing Group: Open Access Hybrid Model Option B
References	Hung, Fletcher, Hornick (CR29) 2016; 29 Bacci, Ferrari, Bertoni, Rimondini, Longhi, Bacchini (CR26) 2000; 18 Koelsche, Kriegsmann, Kommoss, Stichel, Kriegsmann, Vokuhl (CR6) 2019; 145 Xiao, Liu, Wang, Zhu, Gao, Tin (CR43) 2017; 6 Pasic, Shlien, Durbin, Stavropoulos, Baskin, Ray (CR49) 2010; 70 Leavey, Collier (CR28) 2008; 8 Watson, Perrin, Guillemot, Reynaud, Coindre, Karanian (CR8) 2018; 245 Kim, Kwon, Lee, Verma, Rudra, Kim (CR44) 2018; 7 Bray, Pimentel, Melsted, Pachter (CR11) 2016; 34 Romeo, Bovée, Kroon, Tirabosco, Natali, Zanatta (CR24) 2012; 461 Sadri, Barroeta, Pack, Abdullaev, Chatterjee, Puthiyaveettil (CR23) 2014; 465 Koga, Matsui, Asagiri, Kodama, de Crombrugghe, Nakashima (CR47) 2005; 11 Kao, Sung, Zhang, Jungbluth, Huang, Argani (CR30) 2016; 40 Roughley, Mort (CR36) 2014; 1 Domowicz, Sanders, Ragsdale, Schwartz (CR38) 2008; 315 Le Loarer, Pissaloux, Coindre, Tirode, Vince (CR1) 2017; 10 CR3 CR5 Antonescu, Owosho, Zhang, Chen, Deniz, Huryn (CR33) 2017; 41 Kinkor, Vaneček, Svajdler, Mukenšnabl, Veselý, Baxa (CR22) 2014; 50 Cong, Li, Jing, Li (CR50) 2016; 37 Lagarde, Pérot, Kauffmann, Brulard, Dapremont, Hostein (CR14) 2012; 18 Wilkerson, Hayes (CR12) 2010; 26 Cohen-Gogo, Cellier, Coindre, Mosseri, Pierron, Guillemet (CR31) 2014; 61 Kovar, Amatruda, Brunet, Burdach, Cidre-Aranaz, de Alava (CR7) 2016; 7 CR17 Srivastava, Rosenberg, Selig, Rubin, Nielsen (CR32) 2005; 13 CR16 CR15 Stahl, Ranft, Paulussen, Bölling, Vieth, Bielack (CR27) 2011; 57 Qin, Nag, Wang, Zhou, Zhang, Wang (CR45) 2014; 1846 Wang, Marino-Enriquez, Bennett, Zhu, Shen, Eilers (CR51) 2014; 46 Machado, Yoshida, Morales, Abrahão-Machado, Navarro, Cruz (CR20) 2018; 34 Baldauf, Orth, Dallmayer, Marchetto, Gerke, Rubio (CR9) 2017; 9 Croce, Ducoulombier, Ribeiro, Lesluyes, Noel, Amant (CR13) 2018; 31 Szuhai, Ijszenga, de Jong, Karseladze, Tanke, Hogendoorn (CR2) 2009; 15 Le Loarer, Cleven, Bouvier, Castex, Romagosa, Moreau (CR10) 2020; 33 Bui, Przybyl, Million, Van De Rijn, Ganjoo (CR48) 2018; 15 Aigner, Oliveira, Nascimento (CR37) 2004; 17 Macian (CR42) 2005; 5 Wang, Patel, Caragea, Hogendoorn, López-Terrada, Hornick (CR34) 2012; 25 Sandell (CR39) 1994; 28 Toki, Wakai, Sekimizu, Mori, Ichikawa, Kawai (CR18) 2018; 73 Huang, Chen, Zhang, Sung, Agaram, Davis (CR41) 2015; 54 Antonescu (CR19) 2014; 64 Antonescu, Zhang, Chang, Pawel, Travis, Katabi (CR40) 2010; 49 Grünewald, Cidre-Aranaz, Surdez, Tomazou, de Álava, Kovar (CR52) 2018; 4 Greenblatt, Ritter, Wright, Tsang, Hu, Glimcher (CR46) 2013; 110 Bode-Lesniewska, Fritz, Exner, Wagner, Fuchs (CR4) 2019; 2019 Cohen, Sabnis, Krings, Cho, Horvai, Davis (CR21) 2018; 81 Kiani, Chen, Wu, Yee, Yang (CR35) 2002; 12 Brohl, Solomon, Chang, Wang, Song, Sindiri (CR25) 2014; 10 Le Loarer (10.1038/s41379-020-0542-z_bib10) 2020; 33 Hung (10.1038/s41379-020-0542-z_bib29) 2016; 29 Antonescu (10.1038/s41379-020-0542-z_bib33) 2017; 41 Bui (10.1038/s41379-020-0542-z_bib48) 2018; 15 Antonescu (10.1038/s41379-020-0542-z_bib40) 2010; 49 Kinkor (10.1038/s41379-020-0542-z_bib22) 2014; 50 Macian (10.1038/s41379-020-0542-z_bib42) 2005; 5 Brohl (10.1038/s41379-020-0542-z_bib25) 2014; 10 Kao (10.1038/s41379-020-0542-z_bib30) 2016; 40 Koelsche (10.1038/s41379-020-0542-z_bib6) 2019; 145 Sadri (10.1038/s41379-020-0542-z_bib23) 2014; 465 Szuhai (10.1038/s41379-020-0542-z_bib2) 2009; 15 Baldauf (10.1038/s41379-020-0542-z_bib9) 2017; 9 Grünewald (10.1038/s41379-020-0542-z_bib52) 2018; 4 Pasic (10.1038/s41379-020-0542-z_bib49) 2010; 70 Qin (10.1038/s41379-020-0542-z_bib45) 2014; 1846 Kovar (10.1038/s41379-020-0542-z_bib7) 2016; 7 Xiao (10.1038/s41379-020-0542-z_bib43) 2017; 6 Domowicz (10.1038/s41379-020-0542-z_bib38) 2008; 315 Cohen-Gogo (10.1038/s41379-020-0542-z_bib31) 2014; 61 Huang (10.1038/s41379-020-0542-z_bib41) 2015; 54 Kim (10.1038/s41379-020-0542-z_bib44) 2018; 7 Aigner (10.1038/s41379-020-0542-z_bib37) 2004; 17 Leavey (10.1038/s41379-020-0542-z_bib28) 2008; 8 Machado (10.1038/s41379-020-0542-z_bib20) 2018; 34 Romeo (10.1038/s41379-020-0542-z_bib24) 2012; 461 10.1038/s41379-020-0542-z_bib15 10.1038/s41379-020-0542-z_bib16 10.1038/s41379-020-0542-z_bib5 10.1038/s41379-020-0542-z_bib17 Greenblatt (10.1038/s41379-020-0542-z_bib46) 2013; 110 10.1038/s41379-020-0542-z_bib3 Koga (10.1038/s41379-020-0542-z_bib47) 2005; 11 Le Loarer (10.1038/s41379-020-0542-z_bib1) 2017; 10 Kiani (10.1038/s41379-020-0542-z_bib35) 2002; 12 Srivastava (10.1038/s41379-020-0542-z_bib32) 2005; 13 Antonescu (10.1038/s41379-020-0542-z_bib19) 2014; 64 Sandell (10.1038/s41379-020-0542-z_bib39) 1994; 28 Toki (10.1038/s41379-020-0542-z_bib18) 2018; 73 Cong (10.1038/s41379-020-0542-z_bib50) 2016; 37 Roughley (10.1038/s41379-020-0542-z_bib36) 2014; 1 Croce (10.1038/s41379-020-0542-z_bib13) 2018; 31 Bray (10.1038/s41379-020-0542-z_bib11) 2016; 34 Wilkerson (10.1038/s41379-020-0542-z_bib12) 2010; 26 Wang (10.1038/s41379-020-0542-z_bib34) 2012; 25 Watson (10.1038/s41379-020-0542-z_bib8) 2018; 245 Cohen (10.1038/s41379-020-0542-z_bib21) 2018; 81 Lagarde (10.1038/s41379-020-0542-z_bib14) 2012; 18 Bacci (10.1038/s41379-020-0542-z_bib26) 2000; 18 Stahl (10.1038/s41379-020-0542-z_bib27) 2011; 57 Bode-Lesniewska (10.1038/s41379-020-0542-z_bib4) 2019; 2019 Wang (10.1038/s41379-020-0542-z_bib51) 2014; 46 32415264 - Mod Pathol. 2020 May 15
References_xml	– volume: 57 start-page: 549 year: 2011 end-page: 53 ident: CR27 article-title: Risk of recurrence and survival after relapse in patients with Ewing sarcoma publication-title: Pediatr Blood Cancer doi: 10.1002/pbc.23040 – volume: 4 start-page: 5 year: 2018 ident: CR52 article-title: Ewing sarcoma publication-title: Nat Rev Dis Prim doi: 10.1038/s41572-018-0003-x – ident: CR16 – volume: 40 start-page: 1670 year: 2016 end-page: 8 ident: CR30 article-title: BCOR overexpression is a highly sensitive marker in round cell sarcomas with BCOR genetic abnormalities publication-title: Am J Surg Pathol doi: 10.1097/PAS.0000000000000697 – volume: 15 start-page: 11543 year: 2018 end-page: 11543 ident: CR48 article-title: CDKN2A deletion as a prognostic marker: a clinico-genomic analysis of sarcoma patients publication-title: J Clin Oncol doi: 10.1200/JCO.2018.36.15_suppl.11543 – volume: 18 start-page: 826 year: 2012 end-page: 38 ident: CR14 article-title: Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-11-1610 – volume: 28 start-page: 470 year: 1994 end-page: 82 ident: CR39 article-title: In situ expression of collagen and proteoglycan genes in notochord and during skeletal development and growth publication-title: Microsc Res Tech doi: 10.1002/jemt.1070280603 – volume: 2019 start-page: 9386390 year: 2019 ident: CR4 article-title: EWSR1-NFATC2 and FUS-NFATC2 gene fusion-associated mesenchymal tumors: clinicopathologic correlation and literature review publication-title: Sarcoma doi: 10.1155/2019/9386390 – volume: 41 start-page: 941 year: 2017 end-page: 9 ident: CR33 article-title: Sarcomas with cic-rearrangements are a distinct pathologic entity with aggressive outcome: a clinicopathologic and molecular study of 115 cases publication-title: Am J Surg Pathol doi: 10.1097/PAS.0000000000000846 – volume: 1846 start-page: 297 year: 2014 end-page: 311 ident: CR45 article-title: NFAT as cancer target: mission possible? publication-title: Biochim Biophys Acta – volume: 110 start-page: 19914 year: 2013 end-page: 9 ident: CR46 article-title: NFATc1 and NFATc2 repress spontaneous osteoarthritis publication-title: Proc Natl Acad Sci doi: 10.1073/pnas.1320036110 – volume: 145 start-page: 1273 year: 2019 end-page: 81 ident: CR6 article-title: DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1–NFATc2 fusion from Ewing sarcoma publication-title: J Cancer Res Clin Oncol doi: 10.1007/s00432-019-02895-2 – volume: 6 start-page: e26733 year: 2017 ident: CR43 article-title: NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma publication-title: ELife. doi: 10.7554/eLife.26733 – ident: CR15 – volume: 7 start-page: 8613 year: 2016 end-page: 24 ident: CR7 article-title: The second European interdisciplinary Ewing sarcoma research summit-A joint effort to deconstructing the multiple layers of a complex disease publication-title: Oncotarget doi: 10.18632/oncotarget.6937 – volume: 18 start-page: 4 year: 2000 end-page: 4 ident: CR26 article-title: Prognostic factors in nonmetastatic ewing’s sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli publication-title: J Clin Oncol doi: 10.1200/JCO.2000.18.1.4 – volume: 1 year: 2014 ident: CR36 article-title: The role of aggrecan in normal and osteoarthritic cartilage publication-title: J Exp Orthop doi: 10.1186/s40634-014-0008-7 – volume: 34 start-page: 1 year: 2018 end-page: 12 ident: CR20 article-title: Review with novel markers facilitates precise categorization of 41 cases of diagnostically challenging, “undifferentiated small round cell tumors”. A clinicopathologic, immunophenotypic and molecular analysis publication-title: Ann Diagn Pathol doi: 10.1016/j.anndiagpath.2017.11.011 – volume: 81 start-page: 281 year: 2018 end-page: 90 ident: CR21 article-title: EWSR1-NFATC2 gene fusion in a soft tissue tumor with epithelioid round cell morphology and abundant stroma: a case report and review of the literature publication-title: Hum Pathol. doi: 10.1016/j.humpath.2018.03.020 – volume: 11 start-page: 880 year: 2005 end-page: 5 ident: CR47 article-title: NFAT and Osterix cooperatively regulate bone formation publication-title: Nat Med. doi: 10.1038/nm1270 – volume: 33 start-page: 404 year: 2020 end-page: 19 ident: CR10 article-title: A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation publication-title: Mod Pathol doi: 10.1038/s41379-019-0323-8 – volume: 34 start-page: 525 year: 2016 end-page: 7 ident: CR11 article-title: Near-optimal probabilistic RNA-seq quantification publication-title: Nat Biotechnol. doi: 10.1038/nbt.3519 – ident: CR5 – volume: 12 start-page: 19 year: 2002 end-page: 32 ident: CR35 article-title: Structure and function of aggrecan publication-title: Cell Res. doi: 10.1038/sj.cr.7290106 – volume: 245 start-page: 29 year: 2018 end-page: 40 ident: CR8 article-title: Transcriptomic definition of molecular subgroups of small round cell sarcomas publication-title: J Pathol. doi: 10.1002/path.5053 – volume: 64 start-page: 26 year: 2014 end-page: 37 ident: CR19 article-title: Round cell sarcomas beyond Ewing: emerging entities publication-title: Histopathology. doi: 10.1111/his.12281 – volume: 50 start-page: 87 year: 2014 end-page: 91 ident: CR22 article-title: Where does Ewing sarcoma end and begin - two cases of unusual bone tumors with t(20;22)(EWSR1-NFATc2) alteration publication-title: Cesk Patol. – volume: 8 start-page: 617 year: 2008 end-page: 24 ident: CR28 article-title: Ewing sarcoma: prognostic criteria, outcomes and future treatment publication-title: Expert Rev Anticancer Ther doi: 10.1586/14737140.8.4.617 – volume: 31 start-page: 816 year: 2018 end-page: 28 ident: CR13 article-title: Genome profiling is an efficient tool to avoid the STUMP classification of uterine smooth muscle lesions: acomprehensive array-genomic hybridization analysis of 77 tumors publication-title: Mod Pathol. doi: 10.1038/modpathol.2017.185 – volume: 465 start-page: 233 year: 2014 end-page: 9 ident: CR23 article-title: Malignant round cell tumor of bone with EWSR1-NFATC2 gene fusion publication-title: Virchows Arch. doi: 10.1007/s00428-014-1613-7 – volume: 9 start-page: 1587 year: 2017 end-page: 601 ident: CR9 article-title: Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets publication-title: Oncotarget doi: 10.18632/oncotarget.20098 – volume: 10 start-page: e1004475 year: 2014 ident: CR25 article-title: The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation publication-title: PLoS Genet doi: 10.1371/journal.pgen.1004475 – volume: 54 start-page: 267 year: 2015 end-page: 75 ident: CR41 article-title: Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors publication-title: Genes Chromosom Cancer doi: 10.1002/gcc.22240 – volume: 73 start-page: 645 year: 2018 end-page: 52 ident: CR18 article-title: PAX7 immunohistochemical evaluation of Ewing sarcoma and other small round cell tumours publication-title: Histopathology. doi: 10.1111/his.13689 – volume: 17 start-page: 214 year: 2004 end-page: 21 ident: CR37 article-title: Extraskeletal myxoid chondrosarcomas do not show a chondrocytic phenotype publication-title: Mod Pathol. doi: 10.1038/modpathol.3800036 – volume: 46 start-page: 601 year: 2014 end-page: 6 ident: CR51 article-title: Dystrophin is a tumor suppressor in human cancers with myogenic programs publication-title: Nat Genet. doi: 10.1038/ng.2974 – volume: 70 start-page: 160 year: 2010 end-page: 71 ident: CR49 article-title: Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-1902 – volume: 25 start-page: 1378 year: 2012 end-page: 83 ident: CR34 article-title: Expression of ERG, an Ets family transcription factor, identifies ERG-rearranged Ewing sarcoma publication-title: Mod Pathol. doi: 10.1038/modpathol.2012.97 – volume: 13 start-page: 43 year: 2005 end-page: 50 ident: CR32 article-title: Keratin-positive ewing’s sarcoma: an ultrastructural study of 12 cases publication-title: Int J Surg Pathol doi: 10.1177/106689690501300106 – volume: 7 year: 2018 ident: CR44 article-title: Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness publication-title: Oncogenesis doi: 10.1038/s41389-018-0101-3 – ident: CR3 – ident: CR17 – volume: 49 start-page: 1114 year: 2010 end-page: 24 ident: CR40 article-title: EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene publication-title: Genes Chromosom Cancer doi: 10.1002/gcc.20819 – volume: 37 start-page: 9441 year: 2016 end-page: 50 ident: CR50 article-title: Long non-coding RNA tumor suppressor candidate 7 functions as a tumor suppressor and inhibits proliferation in osteosarcoma publication-title: Tumour Biol. doi: 10.1007/s13277-015-4414-y – volume: 5 start-page: 472 year: 2005 end-page: 84 ident: CR42 article-title: NFAT proteins: key regulators of T-cell development and function publication-title: Nat Rev Immunol doi: 10.1038/nri1632 – volume: 15 start-page: 2259 year: 2009 end-page: 68 ident: CR2 article-title: The NFATc2 gene is involved in a novel cloned translocation in a ewing sarcoma variant that couples its function in immunology to oncology publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-08-2184 – volume: 29 start-page: 1324 year: 2016 end-page: 34 ident: CR29 article-title: Evaluation of ETV4 and WT1 expression in CIC-rearranged sarcomas and histologic mimics publication-title: Mod Pathol. doi: 10.1038/modpathol.2016.140 – volume: 461 start-page: 561 year: 2012 end-page: 70 ident: CR24 article-title: Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches publication-title: Virchows Arch. doi: 10.1007/s00428-012-1306-z – volume: 315 start-page: 114 year: 2008 end-page: 24 ident: CR38 article-title: Aggrecan is expressed by embryonic brain glia and regulates astrocyte development publication-title: Dev Biol. doi: 10.1016/j.ydbio.2007.12.014 – volume: 10 start-page: 587 year: 2017 end-page: 620 ident: CR1 article-title: Update on families of round cell sarcomas other than classical ewing sarcomas publication-title: Surg Pathol Clin doi: 10.1016/j.path.2017.04.002 – volume: 26 start-page: 1572 year: 2010 end-page: 3 ident: CR12 article-title: ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking publication-title: Bioinformatics. doi: 10.1093/bioinformatics/btq170 – volume: 61 start-page: 2191 year: 2014 end-page: 8 ident: CR31 article-title: Ewing-like sarcomas with BCOR-CCNB3 fusion transcript: a clinical, radiological and pathological retrospective study from the Société Française des Cancers de L’Enfant publication-title: Pediatr Blood Cancer doi: 10.1002/pbc.25210 – volume: 7 start-page: 8613 year: 2016 ident: 10.1038/s41379-020-0542-z_bib7 article-title: The second European interdisciplinary Ewing sarcoma research summit-A joint effort to deconstructing the multiple layers of a complex disease publication-title: Oncotarget doi: 10.18632/oncotarget.6937 – ident: 10.1038/s41379-020-0542-z_bib5 doi: 10.1016/j.humpath.2019.05.001 – volume: 18 start-page: 4 year: 2000 ident: 10.1038/s41379-020-0542-z_bib26 article-title: Prognostic factors in nonmetastatic ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli publication-title: J Clin Oncol doi: 10.1200/JCO.2000.18.1.4 – volume: 15 start-page: 2259 year: 2009 ident: 10.1038/s41379-020-0542-z_bib2 article-title: The NFATc2 gene is involved in a novel cloned translocation in a ewing sarcoma variant that couples its function in immunology to oncology publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-08-2184 – volume: 1 year: 2014 ident: 10.1038/s41379-020-0542-z_bib36 article-title: The role of aggrecan in normal and osteoarthritic cartilage publication-title: J Exp Orthop doi: 10.1186/s40634-014-0008-7 – volume: 5 start-page: 472 year: 2005 ident: 10.1038/s41379-020-0542-z_bib42 article-title: NFAT proteins: key regulators of T-cell development and function publication-title: Nat Rev Immunol doi: 10.1038/nri1632 – ident: 10.1038/s41379-020-0542-z_bib17 doi: 10.1177/1066896919827093 – volume: 49 start-page: 1114 year: 2010 ident: 10.1038/s41379-020-0542-z_bib40 article-title: EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene publication-title: Genes Chromosom Cancer doi: 10.1002/gcc.20819 – volume: 54 start-page: 267 year: 2015 ident: 10.1038/s41379-020-0542-z_bib41 article-title: Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors publication-title: Genes Chromosom Cancer doi: 10.1002/gcc.22240 – volume: 9 start-page: 1587 year: 2017 ident: 10.1038/s41379-020-0542-z_bib9 article-title: Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets publication-title: Oncotarget doi: 10.18632/oncotarget.20098 – volume: 34 start-page: 525 year: 2016 ident: 10.1038/s41379-020-0542-z_bib11 article-title: Near-optimal probabilistic RNA-seq quantification publication-title: Nat Biotechnol. doi: 10.1038/nbt.3519 – ident: 10.1038/s41379-020-0542-z_bib15 doi: 10.1097/PAS.0000000000001441 – volume: 25 start-page: 1378 year: 2012 ident: 10.1038/s41379-020-0542-z_bib34 article-title: Expression of ERG, an Ets family transcription factor, identifies ERG-rearranged Ewing sarcoma publication-title: Mod Pathol. doi: 10.1038/modpathol.2012.97 – volume: 34 start-page: 1 year: 2018 ident: 10.1038/s41379-020-0542-z_bib20 article-title: Review with novel markers facilitates precise categorization of 41 cases of diagnostically challenging, “undifferentiated small round cell tumors”. A clinicopathologic, immunophenotypic and molecular analysis publication-title: Ann Diagn Pathol doi: 10.1016/j.anndiagpath.2017.11.011 – volume: 315 start-page: 114 year: 2008 ident: 10.1038/s41379-020-0542-z_bib38 article-title: Aggrecan is expressed by embryonic brain glia and regulates astrocyte development publication-title: Dev Biol. doi: 10.1016/j.ydbio.2007.12.014 – volume: 73 start-page: 645 year: 2018 ident: 10.1038/s41379-020-0542-z_bib18 article-title: PAX7 immunohistochemical evaluation of Ewing sarcoma and other small round cell tumours publication-title: Histopathology. doi: 10.1111/his.13689 – volume: 6 start-page: e26733 year: 2017 ident: 10.1038/s41379-020-0542-z_bib43 article-title: NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma publication-title: ELife. doi: 10.7554/eLife.26733 – ident: 10.1038/s41379-020-0542-z_bib3 doi: 10.1097/PAS.0000000000001260 – ident: 10.1038/s41379-020-0542-z_bib16 doi: 10.1002/gcc.22763 – volume: 4 start-page: 5 year: 2018 ident: 10.1038/s41379-020-0542-z_bib52 article-title: Ewing sarcoma publication-title: Nat Rev Dis Prim doi: 10.1038/s41572-018-0003-x – volume: 18 start-page: 826 year: 2012 ident: 10.1038/s41379-020-0542-z_bib14 article-title: Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-11-1610 – volume: 12 start-page: 19 year: 2002 ident: 10.1038/s41379-020-0542-z_bib35 article-title: Structure and function of aggrecan publication-title: Cell Res. doi: 10.1038/sj.cr.7290106 – volume: 64 start-page: 26 year: 2014 ident: 10.1038/s41379-020-0542-z_bib19 article-title: Round cell sarcomas beyond Ewing: emerging entities publication-title: Histopathology. doi: 10.1111/his.12281 – volume: 70 start-page: 160 year: 2010 ident: 10.1038/s41379-020-0542-z_bib49 article-title: Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-1902 – volume: 145 start-page: 1273 year: 2019 ident: 10.1038/s41379-020-0542-z_bib6 article-title: DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1–NFATc2 fusion from Ewing sarcoma publication-title: J Cancer Res Clin Oncol doi: 10.1007/s00432-019-02895-2 – volume: 81 start-page: 281 year: 2018 ident: 10.1038/s41379-020-0542-z_bib21 article-title: EWSR1-NFATC2 gene fusion in a soft tissue tumor with epithelioid round cell morphology and abundant stroma: a case report and review of the literature publication-title: Hum Pathol. doi: 10.1016/j.humpath.2018.03.020 – volume: 50 start-page: 87 year: 2014 ident: 10.1038/s41379-020-0542-z_bib22 article-title: Where does Ewing sarcoma end and begin - two cases of unusual bone tumors with t(20;22)(EWSR1-NFATc2) alteration publication-title: Cesk Patol. – volume: 2019 start-page: 9386390 year: 2019 ident: 10.1038/s41379-020-0542-z_bib4 article-title: EWSR1-NFATC2 and FUS-NFATC2 gene fusion-associated mesenchymal tumors: clinicopathologic correlation and literature review publication-title: Sarcoma doi: 10.1155/2019/9386390 – volume: 33 start-page: 404 year: 2020 ident: 10.1038/s41379-020-0542-z_bib10 article-title: A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation publication-title: Mod Pathol doi: 10.1038/s41379-019-0323-8 – volume: 61 start-page: 2191 year: 2014 ident: 10.1038/s41379-020-0542-z_bib31 article-title: Ewing-like sarcomas with BCOR-CCNB3 fusion transcript: a clinical, radiological and pathological retrospective study from the Société Française des Cancers de L'Enfant publication-title: Pediatr Blood Cancer doi: 10.1002/pbc.25210 – volume: 37 start-page: 9441 year: 2016 ident: 10.1038/s41379-020-0542-z_bib50 article-title: Long non-coding RNA tumor suppressor candidate 7 functions as a tumor suppressor and inhibits proliferation in osteosarcoma publication-title: Tumour Biol. doi: 10.1007/s13277-015-4414-y – volume: 1846 start-page: 297 year: 2014 ident: 10.1038/s41379-020-0542-z_bib45 article-title: NFAT as cancer target: mission possible? publication-title: Biochim Biophys Acta – volume: 40 start-page: 1670 year: 2016 ident: 10.1038/s41379-020-0542-z_bib30 article-title: BCOR overexpression is a highly sensitive marker in round cell sarcomas with BCOR genetic abnormalities publication-title: Am J Surg Pathol doi: 10.1097/PAS.0000000000000697 – volume: 13 start-page: 43 year: 2005 ident: 10.1038/s41379-020-0542-z_bib32 article-title: Keratin-positive ewing's sarcoma: an ultrastructural study of 12 cases publication-title: Int J Surg Pathol doi: 10.1177/106689690501300106 – volume: 29 start-page: 1324 year: 2016 ident: 10.1038/s41379-020-0542-z_bib29 article-title: Evaluation of ETV4 and WT1 expression in CIC-rearranged sarcomas and histologic mimics publication-title: Mod Pathol. doi: 10.1038/modpathol.2016.140 – volume: 11 start-page: 880 year: 2005 ident: 10.1038/s41379-020-0542-z_bib47 article-title: NFAT and Osterix cooperatively regulate bone formation publication-title: Nat Med. doi: 10.1038/nm1270 – volume: 41 start-page: 941 year: 2017 ident: 10.1038/s41379-020-0542-z_bib33 article-title: Sarcomas with cic-rearrangements are a distinct pathologic entity with aggressive outcome: a clinicopathologic and molecular study of 115 cases publication-title: Am J Surg Pathol doi: 10.1097/PAS.0000000000000846 – volume: 15 start-page: 11543 year: 2018 ident: 10.1038/s41379-020-0542-z_bib48 article-title: CDKN2A deletion as a prognostic marker: a clinico-genomic analysis of sarcoma patients publication-title: J Clin Oncol doi: 10.1200/JCO.2018.36.15_suppl.11543 – volume: 26 start-page: 1572 year: 2010 ident: 10.1038/s41379-020-0542-z_bib12 article-title: ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking publication-title: Bioinformatics. doi: 10.1093/bioinformatics/btq170 – volume: 46 start-page: 601 year: 2014 ident: 10.1038/s41379-020-0542-z_bib51 article-title: Dystrophin is a tumor suppressor in human cancers with myogenic programs publication-title: Nat Genet. doi: 10.1038/ng.2974 – volume: 31 start-page: 816 year: 2018 ident: 10.1038/s41379-020-0542-z_bib13 article-title: Genome profiling is an efficient tool to avoid the STUMP classification of uterine smooth muscle lesions: acomprehensive array-genomic hybridization analysis of 77 tumors publication-title: Mod Pathol. doi: 10.1038/modpathol.2017.185 – volume: 8 start-page: 617 year: 2008 ident: 10.1038/s41379-020-0542-z_bib28 article-title: Ewing sarcoma: prognostic criteria, outcomes and future treatment publication-title: Expert Rev Anticancer Ther doi: 10.1586/14737140.8.4.617 – volume: 10 start-page: e1004475 year: 2014 ident: 10.1038/s41379-020-0542-z_bib25 article-title: The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation publication-title: PLoS Genet doi: 10.1371/journal.pgen.1004475 – volume: 28 start-page: 470 year: 1994 ident: 10.1038/s41379-020-0542-z_bib39 article-title: In situ expression of collagen and proteoglycan genes in notochord and during skeletal development and growth publication-title: Microsc Res Tech doi: 10.1002/jemt.1070280603 – volume: 245 start-page: 29 year: 2018 ident: 10.1038/s41379-020-0542-z_bib8 article-title: Transcriptomic definition of molecular subgroups of small round cell sarcomas publication-title: J Pathol. doi: 10.1002/path.5053 – volume: 110 start-page: 19914 year: 2013 ident: 10.1038/s41379-020-0542-z_bib46 article-title: NFATc1 and NFATc2 repress spontaneous osteoarthritis publication-title: Proc Natl Acad Sci doi: 10.1073/pnas.1320036110 – volume: 57 start-page: 549 year: 2011 ident: 10.1038/s41379-020-0542-z_bib27 article-title: Risk of recurrence and survival after relapse in patients with Ewing sarcoma publication-title: Pediatr Blood Cancer doi: 10.1002/pbc.23040 – volume: 17 start-page: 214 year: 2004 ident: 10.1038/s41379-020-0542-z_bib37 article-title: Extraskeletal myxoid chondrosarcomas do not show a chondrocytic phenotype publication-title: Mod Pathol. doi: 10.1038/modpathol.3800036 – volume: 461 start-page: 561 year: 2012 ident: 10.1038/s41379-020-0542-z_bib24 article-title: Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches publication-title: Virchows Arch. doi: 10.1007/s00428-012-1306-z – volume: 10 start-page: 587 year: 2017 ident: 10.1038/s41379-020-0542-z_bib1 article-title: Update on families of round cell sarcomas other than classical ewing sarcomas publication-title: Surg Pathol Clin doi: 10.1016/j.path.2017.04.002 – volume: 465 start-page: 233 year: 2014 ident: 10.1038/s41379-020-0542-z_bib23 article-title: Malignant round cell tumor of bone with EWSR1-NFATC2 gene fusion publication-title: Virchows Arch. doi: 10.1007/s00428-014-1613-7 – volume: 7 year: 2018 ident: 10.1038/s41379-020-0542-z_bib44 article-title: Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness publication-title: Oncogenesis doi: 10.1038/s41389-018-0101-3 – reference: 32415264 - Mod Pathol. 2020 May 15;:
SSID	ssj0014582
Score	2.5171733
Snippet	NFATc2 -rearranged sarcomas ( NFATc2 -Sarcomas) are infrequent round cell tumors characterized by EWSR1-NFATc2 fusions and FUS-NFATc2 fusions. Although our... NFATc2-rearranged sarcomas (NFATc2-Sarcomas) are infrequent round cell tumors characterized by EWSR1-NFATc2 fusions and FUS-NFATc2 fusions. Although our...
SourceID	hal proquest pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	1930
SubjectTerms	13/51 14/32 14/63 38/39 38/43 38/91 692/699/67/1344 692/699/67/1798 Adult Aged Aggrecan Aggrecans - metabolism Biomarkers, Tumor - metabolism Bone cancer Bone Neoplasms - diagnosis Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone tumors Cancer CD99 antigen Chemotherapy Chondrosarcoma Cytogenetics Desmin Female Femur FLI-1 protein Humans Ilium Immunohistochemistry Karyotypes Keratin Laboratory Medicine Life Sciences Male Medical diagnosis Medicine Medicine & Public Health Mesenchyme Middle Aged Neoplasia NFATC Transcription Factors - genetics Oncogene Fusion Oncogene Proteins, Fusion - genetics Osteoid Pathology Patients Pleomorphism Sarcoma Sarcoma - diagnosis Sarcoma - genetics Sarcoma - metabolism Soft tissues Stroma Surgery Tibia Tumor suppressor genes Tumors
Title	NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker
URI	https://link.springer.com/article/10.1038/s41379-020-0542-z https://www.ncbi.nlm.nih.gov/pubmed/32327700 https://www.proquest.com/docview/2475010388 https://www.proquest.com/docview/2394884293 https://hal.science/hal-03882511
Volume	33
WOSCitedRecordID	wos000528304300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1530-0285 dateEnd: 20221231 omitProxy: false ssIdentifier: ssj0014582 issn: 0893-3952 databaseCode: M7P dateStart: 20000101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1530-0285 dateEnd: 20221231 omitProxy: false ssIdentifier: ssj0014582 issn: 0893-3952 databaseCode: 7X7 dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1530-0285 dateEnd: 20221231 omitProxy: false ssIdentifier: ssj0014582 issn: 0893-3952 databaseCode: 7RV dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1530-0285 dateEnd: 20221231 omitProxy: false ssIdentifier: ssj0014582 issn: 0893-3952 databaseCode: BENPR dateStart: 20000101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RFhAXHqWUQFkZxAlqNWsna5sLCtVue4DValXQ3iLHsQVSm7Sb7Urtv-Af48mrQhW9cImi-BFLMx6PPZ_nA3jPVBwbaRkdxlrSSGlD_SIY0tyGkYiFUCqParIJMZ3KxULN2gO3qoVVdjaxNtR5afCM_ID5pshJIOXn8wuKrFEYXW0pNDZga4i-sddnMf_RRxEwJlR7kYpTrmLWRTW5PKi88RaK4ubJOy2MXv-1Lm38RFTkbZfzVri0XoUmT_53_E_hcet_kqRRmGdwzxbb8KBhpLzahoff2lj7c_g9nSQnhtElonnxCkJOKj8rEE_0iTQXKkvkM26s5z4564h294kucmKuVqVXTrwjSeoctqR0RBDjV82K4OkvsS2hKRYkR0fz8WEyJboimhTl2p6SvEEBYgdnCCJa7sD3yfjk8Ji2BA7URJFaUW1dZCKRq1EeGifjyIXaWOcyO2LMv_mtl3UqV95aG2a4VVlmw9BmxmkjtMn4C9gsysK-BBJF-YhJ1CruuzaZcm4oM80z78KNHM8CCDvxpabNbo4kG6dpHWXnMm0knnqJpyjx9DqAD32T8ya1x12V33md6OthUu7j5GuK31CmuFFbDwPY62SftqagSm8EH8DbvthPYozM6MKWl74OV96QeteAB7DbqFr_K-59XiHCMICPne7ddP7P8b66eyiv4RFD3a9RiXuwuVpe2jdw36xXv6rloJ5F-FyI-ikHsPVlPJ3NBwiNnf0BjIkmog
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFD7axvWFy7gFBhgELzBrqZ3UMRJC1VjXaV2FUJH6FhLHFkhbMpquqPsX_BF-I-fk0glN7G0PvFWN41rpd245n_0BvBI6DE1kBe-EScQDnRiOQdDnmfUDFSqldRZUYhNqNIomE_1pBX63e2GIVtn6xMpRZ4Whd-RbAm8lTYIo-nD8g5NqFHVXWwmNGhb7dvETS7by_d5H_H9fC9HfGW8PeKMqwE0Q6BlPrAtMoDLdzXzjojBwfmKsc6ntCoGfsB6wTmcaXYgRRlqdptb3bWpcYlRiUonzrsIV9OOKij01WRZ4HepBVVmrllzqULRdVBltlRgslOZUrGGSJPjpX3Fw9RuxMM-nuOfas1XU69_-357XHbjV5NesVxvEXVix-TpcqxU3F-tw_aDhEtyDX6N-b2wEnxJbmbZYZKzE5RJf6h2rN4wWpNdcR4dNdtQKCW-yJM-YWcwKND7aA8qqM3pZ4ZhiBrOCktHbbWYbwVa60Nvd_byz3RuxpGQJy4u5PWRZzXKkCY6IJDW9D18u5dE8gLW8yO0jYEGQdUVEViNxapNq5zpRmsgUU9Suk6kHfguX2DSnt5OIyGFcsQhkFNcIixFhMSEsPvXgzfKW4_rokosGv0QMLsfRoeOD3jCm7whDVIjOOx5stFiLG1dXxmdA8-DF8jI6Keo8JbktTnCM1Bgo0GSkBw9raC9_SmJOr5Tve_C2xfrZ5P9c7-OLl_IcbgzGB8N4uDfafwI3BdldxcDcgLXZ9MQ-hatmPvteTp9VFszg62WbwB-Pv4YL
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFD7aOph44TJgBAYYBC8wa6mdNDESQmVrt2kjqqYh7S0kjq0hbclouqLuX_B3-HWck0snNLG3PfBWNY5rpd-55Xz2B_BGKN_XoRG86ych91SiOQZBl2fG9QI_CJTKvEpsIoii8OhIjRbgd7sXhmiVrU-sHHVWaHpHviHwVtIkwILNNrSI0dbw09kPTgpS1Glt5TRqiOyZ2U8s38qPu1v4X78VYjg43NzhjcIA156nJjwx1tNekKle5mob-p51E22sTU1PCPyEtYGxKlPoTrTQ0qg0Na5rUm0THSQ6lTjvIiwFmGR4HVj6PIhGB_MeBnWkqhxWSS6VL9qeqgw3SgwdgeJUumHKJPjFX1Fx8Zg4mVcT3ivN2ioGDu_9z0_vPtxtMm_Wr03lASyYfAVu11qcsxVY_tKwDB7Cr2jYP9SCj4nHTJsvMlbicolJ9YHVW0kLUnKu48Y6O20lhtdZkmdMzyYFmiXtDmXV6b2ssCxgGvOFktF7b2YaKVe60N_ePhhs9iOWlCxheTE1Jyyr-Y80wSnRp8aP4OuNPJrH0MmL3DwB5nlZT4RkTxKn1qmythumiUwxee1ZmTrgttCJdXOuO8mLnMQVv0CGcY22GNEWE9riCwfezW85qw81uW7wa8TjfBwdR77T34_pO8ITlajTrgNrLe7ixgmW8SXoHHg1v4zui3pSSW6KcxwjFYYQTIqkA6s1zOc_JTHbDwLXdeB9i_vLyf-53qfXL-UlLCPy4_3daO8Z3BFkghU1cw06k_G5eQ639HTyvRy_aMyZwbebtoE_BwSQKw
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=NFATc2-rearranged+sarcomas%3A+clinicopathologic%2C+molecular%2C+and+cytogenetic+study+of+7+cases+with+evidence+of+AGGRECAN+as+a+novel+diagnostic+marker&rft.jtitle=Modern+pathology&rft.au=Perret%2C+Raul&rft.au=Escuriol%2C+Julien&rft.au=Velasco%2C+Val%C3%A9rie&rft.au=Mayeur%2C+Laetitia&rft.date=2020-10-01&rft.pub=Nature+Publishing+Group+US&rft.issn=0893-3952&rft.eissn=1530-0285&rft.volume=33&rft.issue=10&rft.spage=1930&rft.epage=1944&rft_id=info:doi/10.1038%2Fs41379-020-0542-z&rft.externalDocID=10_1038_s41379_020_0542_z
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0893-3952&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0893-3952&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0893-3952&client=summon