A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion

Burn wounds are one of the most destructive skin traumas that cause more than 180000 deaths each year. Patients with large, irregular burn wounds suffer from slow healing. Dynamic burn wounds have special requirements for hydrogel dressing due to their high frequency movement. To focus on dynamic bu...

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Vydané v:Biomaterials Ročník 276; s. 120838
Hlavní autori: Yuan, Yang, Shen, Shihong, Fan, Daidi
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Elsevier Ltd 01.09.2021
Predmet:
adhesion
antibacterial properties
biocompatible materials
biodegradability
Burn wound dressing
chelation
crosslinking
Double cross-linked
Dynamic wounds
gelation
hydrogels
Injectable self-healing
mechanical properties
schiff bases
Shape adaptability
Tissue adhesion
Double cross-linked
Shape adaptability
Injectable self-healing
Dynamic wounds
Tissue adhesion
Burn wound dressing
ISSN:0142-9612, 1878-5905, 1878-5905
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Shrnutí:Burn wounds are one of the most destructive skin traumas that cause more than 180000 deaths each year. Patients with large, irregular burn wounds suffer from slow healing. Dynamic burn wounds have special requirements for hydrogel dressing due to their high frequency movement. To focus on dynamic burn wounds, we designed a novel double cross-linked hydrogel prepared by Schiff base and catechol-Fe3+ chelation bond. The unique double cross-linked structure of the hydrogel resulted in better physicochemical properties and enhanced efficacy. The enhanced physicochemical properties, such as faster gelation time (52 ± 2 s), stronger mechanical property (535 kPa of G’), enhanced adhesive strength (19.3 kPa) and better self-healing property, made the hydrogel suitable for dynamic wounds. The excellent shape adaptability (97.1 ± 1.3% of recovery) made the hydrogel suitable for wounds with irregular shapes. The hydrogel exhibited not only biodegradability during the wound healing process but also superior inherent antibacterial activity (100% killing ratio) and hemostatic property. The results showed that the hydrogel shortened the healing time of burn wounds to 13 days, and accelerated the reconstruction of skin structure and function. This double cross-linked multifunctional hydrogel is a promising candidate as a dynamic burn wound dressing.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2021.120838