Persistently expressed human chorionic gonadotropin induces premature luteinization and progressive alterations on the reproductive axis in female mice

•Elevated human chorionic gonadotropin hormone (hCG) induced female infertility.•A progressive impairment of the reproductive function occurred from peripuberty.•Persistently elevated levels of hCG induced prolactin synthesis and secretion.•Elevated hCG and prolactin induced premature luteinization...

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Bibliographic Details
Published in:	General and comparative endocrinology Vol. 336; p. 114247
Main Authors:	Marcial Lopez, Agustina, Ratner, Laura D., Martinez, Carolina S., Di Giorgio, Noelia, Poutanen, Matti, Huhtaniemi, Ilpo T., Rulli, Susana B.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 15.05.2023
Subjects:	Animals beta Subunit Chorionic Gonadotropin Chorionic Gonadotropin - pharmacology Chorionic Gonadotropin, beta Subunit, Human - genetics Chorionic Gonadotropin, beta Subunit, Human - metabolism Endocrinology and Diabetes Endokrinologi och diabetes Female Female reproduction genetics Human Human chorionic gonadotropin Humans Infertility Luteinization Mammals Mammals - metabolism metabolism Mice Mice, Transgenic Ovary pharmacology Premature luteinization Prolactin Transgenic Transgenic mice Premature luteinization Ovary Female reproduction Prolactin Human chorionic gonadotropin Transgenic mice
ISSN:	0016-6480, 1095-6840, 1095-6840
Online Access:	Get full text
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