Persistently expressed human chorionic gonadotropin induces premature luteinization and progressive alterations on the reproductive axis in female mice
•Elevated human chorionic gonadotropin hormone (hCG) induced female infertility.•A progressive impairment of the reproductive function occurred from peripuberty.•Persistently elevated levels of hCG induced prolactin synthesis and secretion.•Elevated hCG and prolactin induced premature luteinization...
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| Vydáno v: | General and comparative endocrinology Ročník 336; s. 114247 |
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| Jazyk: | angličtina |
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Elsevier Inc
15.05.2023
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| ISSN: | 0016-6480, 1095-6840, 1095-6840 |
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| Abstract | •Elevated human chorionic gonadotropin hormone (hCG) induced female infertility.•A progressive impairment of the reproductive function occurred from peripuberty.•Persistently elevated levels of hCG induced prolactin synthesis and secretion.•Elevated hCG and prolactin induced premature luteinization of the ovary and progesterone synthesis.•Transgenic female mice overexpressing hCG became a suitable model to study hyperprolactinemia.
The hypothalamic–pituitary–gonadal axis plays a fundamental role in the endocrine regulation of the reproductive function in mammals. Any change in the function of the participating hormones or their receptors can lead to alterations in sexual differentiation, the onset of puberty, infertility, cancer development, and other dysfunctions. In this study, we analyzed the influence of persistently elevated levels of the human chorionic gonadotropin hormone (hCG), a powerful agonist of pituitary luteinizing hormone (LH), on the reproductive axis of female mice. As a consequence of chronic hCG hypersecretion through a global expression of the hCGbeta-subunit in transgenic (TG) female mice, a series of events perturbed the prepubertal to juvenile transition. The imbalance in gonadotropin action was first manifested by precocious puberty and alterations in gonadal hormone production, with the consequent ovarian function disruption and infertility in adulthood. The expansion of cumulus cells in vivo and in vitro, ovulatory capacity, and gene expression of ovulation-related marker genes after hormone stimulation were normal in 3-week-old TG females. However, the expression of genes related to steroidogenesis and luteinization such as Lhcgr, Prlr, and the steroidogenic enzymes Cyp11a1, Cyp17a1, and Cyp19a1 were significantly elevated in the TG females. This study demonstrates that the excessive secretion of hCG in concert with high prolactin, induced premature luteinization, and enhanced ovarian steroidogenesis, as was shown by the up-regulation of luteal cell markers and progesterone synthesis in the TG mice. Furthermore, progressively impaired reproductive function of the TG females occurred from the peripubertal stage to adulthood, thus culminating in infertility. |
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| AbstractList | •Elevated human chorionic gonadotropin hormone (hCG) induced female infertility.•A progressive impairment of the reproductive function occurred from peripuberty.•Persistently elevated levels of hCG induced prolactin synthesis and secretion.•Elevated hCG and prolactin induced premature luteinization of the ovary and progesterone synthesis.•Transgenic female mice overexpressing hCG became a suitable model to study hyperprolactinemia.
The hypothalamic–pituitary–gonadal axis plays a fundamental role in the endocrine regulation of the reproductive function in mammals. Any change in the function of the participating hormones or their receptors can lead to alterations in sexual differentiation, the onset of puberty, infertility, cancer development, and other dysfunctions. In this study, we analyzed the influence of persistently elevated levels of the human chorionic gonadotropin hormone (hCG), a powerful agonist of pituitary luteinizing hormone (LH), on the reproductive axis of female mice. As a consequence of chronic hCG hypersecretion through a global expression of the hCGbeta-subunit in transgenic (TG) female mice, a series of events perturbed the prepubertal to juvenile transition. The imbalance in gonadotropin action was first manifested by precocious puberty and alterations in gonadal hormone production, with the consequent ovarian function disruption and infertility in adulthood. The expansion of cumulus cells in vivo and in vitro, ovulatory capacity, and gene expression of ovulation-related marker genes after hormone stimulation were normal in 3-week-old TG females. However, the expression of genes related to steroidogenesis and luteinization such as Lhcgr, Prlr, and the steroidogenic enzymes Cyp11a1, Cyp17a1, and Cyp19a1 were significantly elevated in the TG females. This study demonstrates that the excessive secretion of hCG in concert with high prolactin, induced premature luteinization, and enhanced ovarian steroidogenesis, as was shown by the up-regulation of luteal cell markers and progesterone synthesis in the TG mice. Furthermore, progressively impaired reproductive function of the TG females occurred from the peripubertal stage to adulthood, thus culminating in infertility. The hypothalamic-pituitary-gonadal axis plays a fundamental role in the endocrine regulation of the reproductive function in mammals. Any change in the function of the participating hormones or their receptors can lead to alterations in sexual differentiation, the onset of puberty, infertility, cancer development, and other dysfunctions. In this study, we analyzed the influence of persistently elevated levels of the human chorionic gonadotropin hormone (hCG), a powerful agonist of pituitary luteinizing hormone (LH), on the reproductive axis of female mice. As a consequence of chronic hCG hypersecretion through a global expression of the hCGbeta-subunit in transgenic (TG) female mice, a series of events perturbed the prepubertal to juvenile transition. The imbalance in gonadotropin action was first manifested by precocious puberty and alterations in gonadal hormone production, with the consequent ovarian function disruption and infertility in adulthood. The expansion of cumulus cells in vivo and in vitro, ovulatory capacity, and gene expression of ovulation-related marker genes after hormone stimulation were normal in 3-week-old TG females. However, the expression of genes related to steroidogenesis and luteinization such as Lhcgr, Prlr, and the steroidogenic enzymes Cyp11a1, Cyp17a1, and Cyp19a1 were significantly elevated in the TG females. This study demonstrates that the excessive secretion of hCG in concert with high prolactin, induced premature luteinization, and enhanced ovarian steroidogenesis, as was shown by the up-regulation of luteal cell markers and progesterone synthesis in the TG mice. Furthermore, progressively impaired reproductive function of the TG females occurred from the peripubertal stage to adulthood, thus culminating in infertility.The hypothalamic-pituitary-gonadal axis plays a fundamental role in the endocrine regulation of the reproductive function in mammals. Any change in the function of the participating hormones or their receptors can lead to alterations in sexual differentiation, the onset of puberty, infertility, cancer development, and other dysfunctions. In this study, we analyzed the influence of persistently elevated levels of the human chorionic gonadotropin hormone (hCG), a powerful agonist of pituitary luteinizing hormone (LH), on the reproductive axis of female mice. As a consequence of chronic hCG hypersecretion through a global expression of the hCGbeta-subunit in transgenic (TG) female mice, a series of events perturbed the prepubertal to juvenile transition. The imbalance in gonadotropin action was first manifested by precocious puberty and alterations in gonadal hormone production, with the consequent ovarian function disruption and infertility in adulthood. The expansion of cumulus cells in vivo and in vitro, ovulatory capacity, and gene expression of ovulation-related marker genes after hormone stimulation were normal in 3-week-old TG females. However, the expression of genes related to steroidogenesis and luteinization such as Lhcgr, Prlr, and the steroidogenic enzymes Cyp11a1, Cyp17a1, and Cyp19a1 were significantly elevated in the TG females. This study demonstrates that the excessive secretion of hCG in concert with high prolactin, induced premature luteinization, and enhanced ovarian steroidogenesis, as was shown by the up-regulation of luteal cell markers and progesterone synthesis in the TG mice. Furthermore, progressively impaired reproductive function of the TG females occurred from the peripubertal stage to adulthood, thus culminating in infertility. The hypothalamic-pituitary-gonadal axis plays a fundamental role in the endocrine regulation of the reproductive function in mammals. Any change in the function of the participating hormones or their receptors can lead to alterations in sexual differentiation, the onset of puberty, infertility, cancer development, and other dysfunctions. In this study, we analyzed the influence of persistently elevated levels of the human chorionic gonadotropin hormone (hCG), a powerful agonist of pituitary luteinizing hormone (LH), on the reproductive axis of female mice. As a consequence of chronic hCG hypersecretion through a global expression of the hCGbeta-subunit in transgenic (TG) female mice, a series of events perturbed the prepubertal to juvenile transition. The imbalance in gonadotropin action was first manifested by precocious puberty and alterations in gonadal hormone production, with the consequent ovarian function disruption and infertility in adulthood. The expansion of cumulus cells in vivo and in vitro, ovulatory capacity, and gene expression of ovulation-related marker genes after hormone stimulation were normal in 3-week-old TG females. However, the expression of genes related to steroidogenesis and luteinization such as Lhcgr, Prlr, and the steroidogenic enzymes Cyp11a1, Cyp17a1, and Cyp19a1 were significantly elevated in the TG females. This study demonstrates that the excessive secretion of hCG in concert with high prolactin, induced premature luteinization, and enhanced ovarian steroidogenesis, as was shown by the up-regulation of luteal cell markers and progesterone synthesis in the TG mice. Furthermore, progressively impaired reproductive function of the TG females occurred from the peripubertal stage to adulthood, thus culminating in infertility. |
| ArticleNumber | 114247 |
| Author | Poutanen, Matti Di Giorgio, Noelia Ratner, Laura D. Rulli, Susana B. Marcial Lopez, Agustina Huhtaniemi, Ilpo T. Martinez, Carolina S. |
| Author_xml | – sequence: 1 givenname: Agustina surname: Marcial Lopez fullname: Marcial Lopez, Agustina organization: Instituto de Biología y Medicina Experimental-CONICET, Vuelta de Obligado 2490 , Buenos Aires, Argentina – sequence: 2 givenname: Laura D. surname: Ratner fullname: Ratner, Laura D. organization: Instituto de Biología y Medicina Experimental-CONICET, Vuelta de Obligado 2490 , Buenos Aires, Argentina – sequence: 3 givenname: Carolina S. surname: Martinez fullname: Martinez, Carolina S. organization: Laboratorio de Bio-nanotecnología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Grupo vinculado GBEyB, IMBICE-CONICET-CICPBA, Bernal, Argentina – sequence: 4 givenname: Noelia surname: Di Giorgio fullname: Di Giorgio, Noelia organization: Instituto de Biología y Medicina Experimental-CONICET, Vuelta de Obligado 2490 , Buenos Aires, Argentina – sequence: 5 givenname: Matti surname: Poutanen fullname: Poutanen, Matti organization: Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland – sequence: 6 givenname: Ilpo T. surname: Huhtaniemi fullname: Huhtaniemi, Ilpo T. organization: Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland – sequence: 7 givenname: Susana B. orcidid: 0000-0001-8833-3309 surname: Rulli fullname: Rulli, Susana B. email: rulli.susana@maimonides.edu organization: Instituto de Biología y Medicina Experimental-CONICET, Vuelta de Obligado 2490 , Buenos Aires, Argentina |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36858273$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/330387$$DView record from Swedish Publication Index (Göteborgs universitet) |
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| Cites_doi | 10.1038/nrendo.2016.70 10.1210/endocr/bqac108 10.1210/me.2005-0185 10.1210/er.2006-0022 10.1007/s00404-009-1248-0 10.1210/en.2003-0403 10.1038/82183 10.1152/ajpendo.91020.2008 10.1152/ajpendo.00243.2013 10.1530/JOE-19-0326 10.1530/rep.1.00661 10.1186/1757-2215-6-68 10.1002/(SICI)1098-2795(199803)49:3<327::AID-MRD13>3.0.CO;2-T 10.1172/JCI41350 10.1258/002367706775404471 10.1016/S0021-9258(19)52451-6 10.1677/ERC-10-0016 10.1172/JCI63937 10.1016/bs.vh.2018.01.009 10.1530/ERC-21-0397 10.1126/science.1171396 10.1210/en.2007-0249 10.1093/nar/29.9.e45 10.1093/biolre/ioy082 10.1210/endo.140.6.6715 10.1093/molehr/gap091 10.1210/mend.12.7.0138 10.1210/en.2002-220490 10.1530/JOE-16-0371 10.1530/JOE-15-0528 10.1210/me.2005-0420 10.3389/fendo.2019.00452 10.1073/pnas.96.21.11998 10.1093/humrep/dey045 10.1210/me.2005-0462 10.1210/en.2019-00038 10.1038/s41598-017-01078-8 10.1210/endo-129-6-3200 10.1210/en.2012-1393 10.1016/j.mce.2011.11.002 10.2108/zsj.13.609 10.1095/biolreprod23.3.545 |
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| Keywords | Premature luteinization Ovary Female reproduction Prolactin Human chorionic gonadotropin Transgenic mice |
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| References | Eppig (b0065) 1980; 23 Cornejo-Cortés, Sánchez-Torres, Vázquez-Chagoyán, Suárez-Gómez, Garrido-Fariña, Meraz-Ríos (b0055) 2006; 40 Assidi, Richard, Sirard (b0015) 2013; 6 Hillier, S.G., 2009. The ovary: from basic research to clinic. Mol. Hum. Reprod. 15, 763. doi: 10.1093/molehr/gap091. Brown, Khant Aung, Phillipps, Barad, Lein, Boehm, Szawka, Grattan (b0035) 2019; 160 Pangas, Li, Robertson, Matzuk (b0145) 2006; 20 Richards (b0185) 2018; 107 Richards, Pangas (b0190) 2010; 120 Pfaffl (b0165) 2001; 29 Kiliçdag, Haydardedeoglu, Cok, Hacivelioglu, Bagis (b0125) 2010; 281 Sonigo, Bouilly, Carré, Tolle, Caraty, Tello, Simony-Conesa, Millar, Young, Binart (b0220) 2012; 122 Peng, Hsueh, LaPolt, Bjersing, Ny (b0160) 1991; 129 Riccetti, Yvinec, Klett, Gallay, Combarnous, Reiter, Simoni, Casarini, Ayoub (b0180) 2017; 7 Rulli, Huhtaniemi (b0205) 2005; 130 Bagnjuk, Mayerhofer (b0030) 2019; 10 Davis, Lennard, Lee, Tiano, Morham, Wetsel, Langenbach (b0060) 1999; 140 Hernandez-Gonzalez, Gonzalez-Robayna, Shimada, Wayne, Ochsner, White, Richards (b0105) 2006; 20 Kuorelahti, Rulli, Huhtaniemi, Poutanen (b0130) 2007; 148 Check, Wilson, Choe, Amui, Brasile (b0040) 2010; 37 Faraoni, Camilletti, Abeledo-Machado, Ratner, De Fino, Huhtaniemi, Rulli, Díaz-Torga (b0085) 2017; 232 Evans, Healy, DeCherney, Hill (b0075) 2018; 99 Rulli, Ahtiainen, Mäkelä, Toppari, Poutanen, Huhtaniemi (b0200) 2003; 144 Stocco, Telleria, Gibori (b0225) 2007; 28 Satou, Yamanouchi (b0215) 1996; 13 Ratner, Stevens, Bonaventura, Lux-Lantos, Poutanen, Calandra, Huhtaniemi, Rulli (b0175) 2016; 230 Eppig, Pendola, Wigglesworth (b0070) 1998; 49 Herbison (b0100) 2016; 12 Bachelot, A., Carré, N., Mialon, O., Matelot, M., Servel, N., Monget, P., Ahtiainen, P., Huhtaniemi, I., Binart, N., 2013. The permissive role of prolactin as a regulator of luteinizing hormone action in the female mouse ovary and extragonadal tumorigenesis. Am. J. Physiol. Endocrinol. Metab. 305, E845-852. Lowry, Rosebrough, Farr, Randall (b0135) 1951; 193 Luo, Zuñiga, Edison, Palla, Dong, Parker-Thornburg (b0140) 2011; 50 White, Leonardsson, Rosewell, Ann Jacobs, Milligan, Parker (b0230) 2000; 6 Faraoni, Abeledo Machado, Pérez, Marcial López, Camilletti, Peña-Zanoni, Rulli, Gutiérrez, Díaz-Torga (b0090) 2020; 244 Peña-Zanoni, Faraoni, Abeledo-Machado, Perez, Marcial López, Camilletti, Gutierrez, Rulli, Diaz-Torga (b0155) 2022; 29 Ratner, Gonzalez, Ahtiainen, Di Giorgio, Poutanen, Calandra, Huhtaniemi, Rulli (b0170) 2012; 153 Robker, Richards (b0195) 1998; 12 Bachelot, Beaufaron, Servel, Kedzia, Monget, Kelly, Gibori, Binart (b0020) 2009; 297 Fan, Liu, Shimada, Sterneck, Johnson, Hedrick, Richards (b0080) 2009; 324 Abeledo-Machado, A., Peña-Zanoni, M., Bornancini, D., Camilletti, M. A., Faraoni, E. Y., Marcial, A., Rulli, S., Alhenc-Gelas, F., Díaz-Torga, G. S. 2022. Sex-specific regulation of prolactin secretion by pituitary bradykinin receptors. Endocrinology. 163, bqac108. doi: 10.1210/endocr/bqac108. Pascuali, Scotti, Di Pietro, Oubiña, Bas, May, Gómez Muñoz, Cuasnicú, Cohen, Tesone, Abramovich, Parborell (b0150) 2018; 33 Ahtiainen, Sharp, Rulli, Rivero-Müller, Mamaeva, Röytta, Huhtaniemi (b0010) 2010; 17 10.1152/ajpendo.00243.20130. Conti, Hsieh, Zamah, Oh (b0050) 2012; 356 Jin, Richard, Kuo, D'Ercole, Conti (b0120) 1999; 96 Rulli, Kuorelahti, Karaer, Pelliniemi, Poutanen, Huhtaniemi (b0210) 2002; 143 Conti, Hsieh, Park, Su (b0045) 2006; 20 Peng (10.1016/j.ygcen.2023.114247_b0160) 1991; 129 10.1016/j.ygcen.2023.114247_b0110 Kuorelahti (10.1016/j.ygcen.2023.114247_b0130) 2007; 148 Jin (10.1016/j.ygcen.2023.114247_b0120) 1999; 96 Ratner (10.1016/j.ygcen.2023.114247_b0175) 2016; 230 Riccetti (10.1016/j.ygcen.2023.114247_b0180) 2017; 7 Ahtiainen (10.1016/j.ygcen.2023.114247_b0010) 2010; 17 Ratner (10.1016/j.ygcen.2023.114247_b0170) 2012; 153 Davis (10.1016/j.ygcen.2023.114247_b0060) 1999; 140 Faraoni (10.1016/j.ygcen.2023.114247_b0090) 2020; 244 Pascuali (10.1016/j.ygcen.2023.114247_b0150) 2018; 33 Kiliçdag (10.1016/j.ygcen.2023.114247_b0125) 2010; 281 Brown (10.1016/j.ygcen.2023.114247_b0035) 2019; 160 Conti (10.1016/j.ygcen.2023.114247_b0050) 2012; 356 Eppig (10.1016/j.ygcen.2023.114247_b0065) 1980; 23 Evans (10.1016/j.ygcen.2023.114247_b0075) 2018; 99 Lowry (10.1016/j.ygcen.2023.114247_b0135) 1951; 193 Pfaffl (10.1016/j.ygcen.2023.114247_b0165) 2001; 29 Rulli (10.1016/j.ygcen.2023.114247_b0200) 2003; 144 Faraoni (10.1016/j.ygcen.2023.114247_b0085) 2017; 232 Conti (10.1016/j.ygcen.2023.114247_b0045) 2006; 20 Herbison (10.1016/j.ygcen.2023.114247_b0100) 2016; 12 Luo (10.1016/j.ygcen.2023.114247_b0140) 2011; 50 Robker (10.1016/j.ygcen.2023.114247_b0195) 1998; 12 10.1016/j.ygcen.2023.114247_b0025 Sonigo (10.1016/j.ygcen.2023.114247_b0220) 2012; 122 10.1016/j.ygcen.2023.114247_b0005 White (10.1016/j.ygcen.2023.114247_b0230) 2000; 6 Hernandez-Gonzalez (10.1016/j.ygcen.2023.114247_b0105) 2006; 20 Rulli (10.1016/j.ygcen.2023.114247_b0210) 2002; 143 Bagnjuk (10.1016/j.ygcen.2023.114247_b0030) 2019; 10 Peña-Zanoni (10.1016/j.ygcen.2023.114247_b0155) 2022; 29 Rulli (10.1016/j.ygcen.2023.114247_b0205) 2005; 130 Eppig (10.1016/j.ygcen.2023.114247_b0070) 1998; 49 Satou (10.1016/j.ygcen.2023.114247_b0215) 1996; 13 Fan (10.1016/j.ygcen.2023.114247_b0080) 2009; 324 Richards (10.1016/j.ygcen.2023.114247_b0190) 2010; 120 Check (10.1016/j.ygcen.2023.114247_b0040) 2010; 37 Assidi (10.1016/j.ygcen.2023.114247_b0015) 2013; 6 Cornejo-Cortés (10.1016/j.ygcen.2023.114247_b0055) 2006; 40 Stocco (10.1016/j.ygcen.2023.114247_b0225) 2007; 28 Bachelot (10.1016/j.ygcen.2023.114247_b0020) 2009; 297 Pangas (10.1016/j.ygcen.2023.114247_b0145) 2006; 20 Richards (10.1016/j.ygcen.2023.114247_b0185) 2018; 107 |
| References_xml | – volume: 13 start-page: 609 year: 1996 end-page: 613 ident: b0215 article-title: Inhibitory effect of progesterone on sexual receptivity in female rats: a temporal relationship to estrogen administration publication-title: Zoolog. Sci. – volume: 6 start-page: 1368 year: 2000 end-page: 1374 ident: b0230 article-title: The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility publication-title: Nat. Med. – reference: Abeledo-Machado, A., Peña-Zanoni, M., Bornancini, D., Camilletti, M. A., Faraoni, E. Y., Marcial, A., Rulli, S., Alhenc-Gelas, F., Díaz-Torga, G. S. 2022. Sex-specific regulation of prolactin secretion by pituitary bradykinin receptors. Endocrinology. 163, bqac108. doi: 10.1210/endocr/bqac108. – volume: 28 start-page: 117 year: 2007 end-page: 149 ident: b0225 article-title: The molecular control of corpus luteum formation, function, and regression publication-title: Endocr. Rev. – volume: 40 start-page: 87 year: 2006 end-page: 95 ident: b0055 article-title: Rat embryo quality and production efficiency are dependent on gonadotrophin dose in superovulatory treatments publication-title: Lab. Anim. – volume: 140 start-page: 2685 year: 1999 end-page: 2695 ident: b0060 article-title: Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1b publication-title: Endocrinology – volume: 17 start-page: 611 year: 2010 end-page: 621 ident: b0010 article-title: Enhanced LH action in transgenic female mice expressing hCGβ-subunit induces pituitary prolactinomas; the role of high progesterone levels publication-title: Endocr. Relat. Cancer – volume: 148 start-page: 3694 year: 2007 end-page: 3703 ident: b0130 article-title: hCG upregulates wnt5b and wnt7b in the mammary gland and hCG{beta} transgenic female mice present with mammary gland tumors exhibiting characteristics of the Wnt/{beta}-catenin pathway activation publication-title: Endocrinology. – volume: 20 start-page: 1300 year: 2006 end-page: 1321 ident: b0105 article-title: Gene expression profiles of cumulus cell oocyte complexes during ovulation reveal cumulus cells express neuronal and immune-related genes: Does this expand their role in the ovulation process? publication-title: Mol. Endocrinol. – volume: 107 start-page: 1 year: 2018 end-page: 25 ident: b0185 article-title: The ovarian cycle publication-title: Vitam. Horm. – reference: Hillier, S.G., 2009. The ovary: from basic research to clinic. Mol. Hum. Reprod. 15, 763. doi: 10.1093/molehr/gap091. – volume: 129 start-page: 3200 year: 1991 end-page: 3207 ident: b0160 article-title: Localization of luteinizing hormone receptor messenger ribonucleic acid expression in ovarian cell types during follicle development and ovulation publication-title: Endocrinology – volume: 160 start-page: 1323 year: 2019 end-page: 1332 ident: b0035 article-title: Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus publication-title: Endocrinology – volume: 297 start-page: E676 year: 2009 end-page: E684 ident: b0020 article-title: Prolactin independent rescue of mouse corpus luteum lifespan: identification of prolactin and luteinizing hormone target genes publication-title: Am. J. Physiol. Endocrinol. Metab. – volume: 29 start-page: e45 year: 2001 ident: b0165 article-title: A new mathematical model for relative quantification in real-time RT-PCR publication-title: Nucleic Acids Res. – volume: 356 start-page: 65 year: 2012 end-page: 73 ident: b0050 article-title: Novel signaling mechanisms in the ovary during oocyte maturation and ovulation publication-title: Mol. Cell. Endocrinol. – reference: 10.1152/ajpendo.00243.20130. – volume: 29 start-page: 359 year: 2022 end-page: 373 ident: b0155 article-title: Oophorectomy improves pituitary activin inhibitory function preventing lactotroph hyperplasia development publication-title: Endocr. Relat. Cancer. – volume: 122 start-page: 3791 year: 2012 end-page: 3795 ident: b0220 article-title: Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration publication-title: J. Clin. Invest. – volume: 96 start-page: 11998 year: 1999 end-page: 12003 ident: b0120 article-title: Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D deficient mice publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 12 start-page: 924 year: 1998 end-page: 940 ident: b0195 article-title: Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1 publication-title: Mol. Endocrinol. – volume: 130 start-page: 283 year: 2005 end-page: 291 ident: b0205 article-title: What have gonadotrophin overexpressing transgenic mice taught us about gonadal function? publication-title: Reproduction – volume: 143 start-page: 4084 year: 2002 end-page: 4096 ident: b0210 article-title: Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin publication-title: Endocrinology – volume: 23 start-page: 545 year: 1980 end-page: 552 ident: b0065 article-title: Regulation of cumulus oophorus expansion by gonadotropins publication-title: Biol. Reprod. – volume: 7 start-page: 940 year: 2017 ident: b0180 article-title: Human luteinizing hormone and chorionic gonadotropin display biased agonism at the LH and LH/CG receptors publication-title: Sci. Rep. – volume: 49 start-page: 327 year: 1998 end-page: 332 ident: b0070 article-title: Mouse oocytes suppress cAMP-induced expression of LH receptor mRNA by granulosa cells publication-title: Mol. Reprod. Dev. – volume: 153 start-page: 5980 year: 2012 end-page: 5992 ident: b0170 article-title: Short-term pharmacological suppression of the hyperprolactinemia of infertile hCG-overproducing female mice persistently restores their fertility publication-title: Endocrinology – volume: 232 start-page: 535 year: 2017 end-page: 546 ident: b0085 article-title: Sex differences in the development of prolactinoma in mice overexpressing hCGβ: role of TGFβ1 publication-title: J. Endocrinol. – volume: 12 start-page: 452 year: 2016 end-page: 466 ident: b0100 article-title: Control of puberty onset and fertility by gonadotropin-releasing hormone neurons publication-title: Nat. Rev. Endocrinol. – volume: 20 start-page: 715 year: 2006 end-page: 723 ident: b0045 article-title: Role of the epidermal growth factor network in ovarian follicles publication-title: Mol. Endocrinol. – volume: 144 start-page: 4980 year: 2003 end-page: 4990 ident: b0200 article-title: Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin publication-title: Endocrinology – volume: 37 start-page: 179 year: 2010 end-page: 180 ident: b0040 article-title: Evidence that high serum progesterone (P) levels on day of human chorionic gonadotropin (hCG) injection have no adverse effect on the embryo itself as determined by pregnancy outcome following embryo transfer using donated eggs publication-title: Clin. Exp. Obstet. Gynecol. – volume: 50 start-page: 471 year: 2011 end-page: 478 ident: b0140 article-title: Superovulation strategies for 6 commonly used mouse strains publication-title: J. Am. Assoc. Lab. Anim. Sci. – volume: 99 start-page: 45 year: 2018 end-page: 51 ident: b0075 article-title: Adverse effect of prematurely elevated progesterone in in vitro fertilization cycles: a literature review publication-title: Biol. Reprod. – volume: 20 start-page: 1406 year: 2006 end-page: 1422 ident: b0145 article-title: Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice publication-title: Mol. Endocrinol. – volume: 281 start-page: 747 year: 2010 end-page: 752 ident: b0125 article-title: Premature progesterone elevation impairs implantation and live birth rates in GnRH-agonist IVF/ICSI cycles publication-title: Arch. Gynecol. Obstet. – volume: 193 start-page: 265 year: 1951 end-page: 275 ident: b0135 article-title: Protein measurement with the Folin phenol reagent publication-title: J. Biol. Chem. – volume: 10 start-page: 452 year: 2019 ident: b0030 article-title: Human luteinized granulosa cells-A cellular model for the human corpus luteum publication-title: Front. Endocrinol. (Lausanne). – volume: 324 start-page: 938 year: 2009 end-page: 941 ident: b0080 article-title: MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility publication-title: Science – volume: 230 start-page: 157 year: 2016 end-page: 169 ident: b0175 article-title: Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice publication-title: J. Endocrinol. – volume: 33 start-page: 844 year: 2018 end-page: 859 ident: b0150 article-title: Ceramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure publication-title: Hum. Reprod. – volume: 244 start-page: 415 year: 2020 end-page: 429 ident: b0090 article-title: Activin-inhibitory action on lactotrophs is decreased in lactotroph hyperplasia publication-title: J. Endocrinol. – volume: 120 start-page: 963 year: 2010 end-page: 972 ident: b0190 article-title: The ovary: basic biology and clinical implications publication-title: J. Clin. Invest. – volume: 6 start-page: 68 year: 2013 ident: b0015 article-title: FSH in vitro versus LH in vivo: similar genomic effects on the cumulus publication-title: J. Ovarian Res. – reference: Bachelot, A., Carré, N., Mialon, O., Matelot, M., Servel, N., Monget, P., Ahtiainen, P., Huhtaniemi, I., Binart, N., 2013. The permissive role of prolactin as a regulator of luteinizing hormone action in the female mouse ovary and extragonadal tumorigenesis. Am. J. Physiol. Endocrinol. Metab. 305, E845-852. – volume: 12 start-page: 452 year: 2016 ident: 10.1016/j.ygcen.2023.114247_b0100 article-title: Control of puberty onset and fertility by gonadotropin-releasing hormone neurons publication-title: Nat. Rev. Endocrinol. doi: 10.1038/nrendo.2016.70 – ident: 10.1016/j.ygcen.2023.114247_b0005 doi: 10.1210/endocr/bqac108 – volume: 20 start-page: 715 year: 2006 ident: 10.1016/j.ygcen.2023.114247_b0045 article-title: Role of the epidermal growth factor network in ovarian follicles publication-title: Mol. Endocrinol. doi: 10.1210/me.2005-0185 – volume: 28 start-page: 117 year: 2007 ident: 10.1016/j.ygcen.2023.114247_b0225 article-title: The molecular control of corpus luteum formation, function, and regression publication-title: Endocr. Rev. doi: 10.1210/er.2006-0022 – volume: 281 start-page: 747 year: 2010 ident: 10.1016/j.ygcen.2023.114247_b0125 article-title: Premature progesterone elevation impairs implantation and live birth rates in GnRH-agonist IVF/ICSI cycles publication-title: Arch. Gynecol. Obstet. doi: 10.1007/s00404-009-1248-0 – volume: 144 start-page: 4980 year: 2003 ident: 10.1016/j.ygcen.2023.114247_b0200 article-title: Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin publication-title: Endocrinology doi: 10.1210/en.2003-0403 – volume: 6 start-page: 1368 year: 2000 ident: 10.1016/j.ygcen.2023.114247_b0230 article-title: The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility publication-title: Nat. Med. doi: 10.1038/82183 – volume: 297 start-page: E676 year: 2009 ident: 10.1016/j.ygcen.2023.114247_b0020 article-title: Prolactin independent rescue of mouse corpus luteum lifespan: identification of prolactin and luteinizing hormone target genes publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.91020.2008 – ident: 10.1016/j.ygcen.2023.114247_b0025 doi: 10.1152/ajpendo.00243.2013 – volume: 244 start-page: 415 year: 2020 ident: 10.1016/j.ygcen.2023.114247_b0090 article-title: Activin-inhibitory action on lactotrophs is decreased in lactotroph hyperplasia publication-title: J. Endocrinol. doi: 10.1530/JOE-19-0326 – volume: 130 start-page: 283 year: 2005 ident: 10.1016/j.ygcen.2023.114247_b0205 article-title: What have gonadotrophin overexpressing transgenic mice taught us about gonadal function? publication-title: Reproduction doi: 10.1530/rep.1.00661 – volume: 6 start-page: 68 year: 2013 ident: 10.1016/j.ygcen.2023.114247_b0015 article-title: FSH in vitro versus LH in vivo: similar genomic effects on the cumulus publication-title: J. Ovarian Res. doi: 10.1186/1757-2215-6-68 – volume: 49 start-page: 327 year: 1998 ident: 10.1016/j.ygcen.2023.114247_b0070 article-title: Mouse oocytes suppress cAMP-induced expression of LH receptor mRNA by granulosa cells in vitro publication-title: Mol. Reprod. Dev. doi: 10.1002/(SICI)1098-2795(199803)49:3<327::AID-MRD13>3.0.CO;2-T – volume: 120 start-page: 963 year: 2010 ident: 10.1016/j.ygcen.2023.114247_b0190 article-title: The ovary: basic biology and clinical implications publication-title: J. Clin. Invest. doi: 10.1172/JCI41350 – volume: 40 start-page: 87 year: 2006 ident: 10.1016/j.ygcen.2023.114247_b0055 article-title: Rat embryo quality and production efficiency are dependent on gonadotrophin dose in superovulatory treatments publication-title: Lab. Anim. doi: 10.1258/002367706775404471 – volume: 193 start-page: 265 issue: 1 year: 1951 ident: 10.1016/j.ygcen.2023.114247_b0135 article-title: Protein measurement with the Folin phenol reagent publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)52451-6 – volume: 50 start-page: 471 year: 2011 ident: 10.1016/j.ygcen.2023.114247_b0140 article-title: Superovulation strategies for 6 commonly used mouse strains publication-title: J. Am. Assoc. Lab. Anim. Sci. – volume: 17 start-page: 611 year: 2010 ident: 10.1016/j.ygcen.2023.114247_b0010 article-title: Enhanced LH action in transgenic female mice expressing hCGβ-subunit induces pituitary prolactinomas; the role of high progesterone levels publication-title: Endocr. Relat. Cancer doi: 10.1677/ERC-10-0016 – volume: 122 start-page: 3791 year: 2012 ident: 10.1016/j.ygcen.2023.114247_b0220 article-title: Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration publication-title: J. Clin. Invest. doi: 10.1172/JCI63937 – volume: 107 start-page: 1 year: 2018 ident: 10.1016/j.ygcen.2023.114247_b0185 article-title: The ovarian cycle publication-title: Vitam. Horm. doi: 10.1016/bs.vh.2018.01.009 – volume: 29 start-page: 359 year: 2022 ident: 10.1016/j.ygcen.2023.114247_b0155 article-title: Oophorectomy improves pituitary activin inhibitory function preventing lactotroph hyperplasia development publication-title: Endocr. Relat. Cancer. doi: 10.1530/ERC-21-0397 – volume: 37 start-page: 179 year: 2010 ident: 10.1016/j.ygcen.2023.114247_b0040 article-title: Evidence that high serum progesterone (P) levels on day of human chorionic gonadotropin (hCG) injection have no adverse effect on the embryo itself as determined by pregnancy outcome following embryo transfer using donated eggs publication-title: Clin. Exp. Obstet. Gynecol. – volume: 324 start-page: 938 year: 2009 ident: 10.1016/j.ygcen.2023.114247_b0080 article-title: MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility publication-title: Science doi: 10.1126/science.1171396 – volume: 148 start-page: 3694 year: 2007 ident: 10.1016/j.ygcen.2023.114247_b0130 article-title: hCG upregulates wnt5b and wnt7b in the mammary gland and hCG{beta} transgenic female mice present with mammary gland tumors exhibiting characteristics of the Wnt/{beta}-catenin pathway activation publication-title: Endocrinology. doi: 10.1210/en.2007-0249 – volume: 29 start-page: e45 year: 2001 ident: 10.1016/j.ygcen.2023.114247_b0165 article-title: A new mathematical model for relative quantification in real-time RT-PCR publication-title: Nucleic Acids Res. doi: 10.1093/nar/29.9.e45 – volume: 99 start-page: 45 year: 2018 ident: 10.1016/j.ygcen.2023.114247_b0075 article-title: Adverse effect of prematurely elevated progesterone in in vitro fertilization cycles: a literature review publication-title: Biol. Reprod. doi: 10.1093/biolre/ioy082 – volume: 140 start-page: 2685 year: 1999 ident: 10.1016/j.ygcen.2023.114247_b0060 article-title: Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1b publication-title: Endocrinology doi: 10.1210/endo.140.6.6715 – ident: 10.1016/j.ygcen.2023.114247_b0110 doi: 10.1093/molehr/gap091 – volume: 12 start-page: 924 year: 1998 ident: 10.1016/j.ygcen.2023.114247_b0195 article-title: Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1 publication-title: Mol. Endocrinol. doi: 10.1210/mend.12.7.0138 – volume: 143 start-page: 4084 year: 2002 ident: 10.1016/j.ygcen.2023.114247_b0210 article-title: Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin publication-title: Endocrinology doi: 10.1210/en.2002-220490 – volume: 232 start-page: 535 year: 2017 ident: 10.1016/j.ygcen.2023.114247_b0085 article-title: Sex differences in the development of prolactinoma in mice overexpressing hCGβ: role of TGFβ1 publication-title: J. Endocrinol. doi: 10.1530/JOE-16-0371 – volume: 230 start-page: 157 year: 2016 ident: 10.1016/j.ygcen.2023.114247_b0175 article-title: Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice publication-title: J. Endocrinol. doi: 10.1530/JOE-15-0528 – volume: 20 start-page: 1300 year: 2006 ident: 10.1016/j.ygcen.2023.114247_b0105 article-title: Gene expression profiles of cumulus cell oocyte complexes during ovulation reveal cumulus cells express neuronal and immune-related genes: Does this expand their role in the ovulation process? publication-title: Mol. Endocrinol. doi: 10.1210/me.2005-0420 – volume: 10 start-page: 452 year: 2019 ident: 10.1016/j.ygcen.2023.114247_b0030 article-title: Human luteinized granulosa cells-A cellular model for the human corpus luteum publication-title: Front. Endocrinol. (Lausanne). doi: 10.3389/fendo.2019.00452 – volume: 96 start-page: 11998 year: 1999 ident: 10.1016/j.ygcen.2023.114247_b0120 article-title: Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D deficient mice publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.96.21.11998 – volume: 33 start-page: 844 year: 2018 ident: 10.1016/j.ygcen.2023.114247_b0150 article-title: Ceramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure publication-title: Hum. Reprod. doi: 10.1093/humrep/dey045 – volume: 20 start-page: 1406 year: 2006 ident: 10.1016/j.ygcen.2023.114247_b0145 article-title: Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice publication-title: Mol. Endocrinol. doi: 10.1210/me.2005-0462 – volume: 160 start-page: 1323 year: 2019 ident: 10.1016/j.ygcen.2023.114247_b0035 article-title: Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus publication-title: Endocrinology doi: 10.1210/en.2019-00038 – volume: 7 start-page: 940 year: 2017 ident: 10.1016/j.ygcen.2023.114247_b0180 article-title: Human luteinizing hormone and chorionic gonadotropin display biased agonism at the LH and LH/CG receptors publication-title: Sci. Rep. doi: 10.1038/s41598-017-01078-8 – volume: 129 start-page: 3200 year: 1991 ident: 10.1016/j.ygcen.2023.114247_b0160 article-title: Localization of luteinizing hormone receptor messenger ribonucleic acid expression in ovarian cell types during follicle development and ovulation publication-title: Endocrinology doi: 10.1210/endo-129-6-3200 – volume: 153 start-page: 5980 year: 2012 ident: 10.1016/j.ygcen.2023.114247_b0170 article-title: Short-term pharmacological suppression of the hyperprolactinemia of infertile hCG-overproducing female mice persistently restores their fertility publication-title: Endocrinology doi: 10.1210/en.2012-1393 – volume: 356 start-page: 65 year: 2012 ident: 10.1016/j.ygcen.2023.114247_b0050 article-title: Novel signaling mechanisms in the ovary during oocyte maturation and ovulation publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2011.11.002 – volume: 13 start-page: 609 year: 1996 ident: 10.1016/j.ygcen.2023.114247_b0215 article-title: Inhibitory effect of progesterone on sexual receptivity in female rats: a temporal relationship to estrogen administration publication-title: Zoolog. Sci. doi: 10.2108/zsj.13.609 – volume: 23 start-page: 545 year: 1980 ident: 10.1016/j.ygcen.2023.114247_b0065 article-title: Regulation of cumulus oophorus expansion by gonadotropins in vivo and in vitro publication-title: Biol. Reprod. doi: 10.1095/biolreprod23.3.545 |
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| Snippet | •Elevated human chorionic gonadotropin hormone (hCG) induced female infertility.•A progressive impairment of the reproductive function occurred from... The hypothalamic-pituitary-gonadal axis plays a fundamental role in the endocrine regulation of the reproductive function in mammals. Any change in the... |
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| SubjectTerms | Animals beta Subunit Chorionic Gonadotropin Chorionic Gonadotropin - pharmacology Chorionic Gonadotropin, beta Subunit, Human - genetics Chorionic Gonadotropin, beta Subunit, Human - metabolism Endocrinology and Diabetes Endokrinologi och diabetes Female Female reproduction genetics Human Human chorionic gonadotropin Humans Infertility Luteinization Mammals Mammals - metabolism metabolism Mice Mice, Transgenic Ovary pharmacology Premature luteinization Prolactin Transgenic Transgenic mice |
| Title | Persistently expressed human chorionic gonadotropin induces premature luteinization and progressive alterations on the reproductive axis in female mice |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0016648023000527 https://dx.doi.org/10.1016/j.ygcen.2023.114247 https://www.ncbi.nlm.nih.gov/pubmed/36858273 https://www.proquest.com/docview/2781622665 https://gup.ub.gu.se/publication/330387 |
| Volume | 336 |
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