Icatibant Acts as a Balanced Ligand of MRGPRX2 in Human Skin Mast Cells

MRGPRX2 (Mas-related G protein-coupled receptor member X2) is implicated in mast cell (MC)-driven disorders due to its ability to bind diverse ligands, which may be G-protein-biased or balanced, with the latter activating both G-proteins and the β-arrestin pathway. Icatibant, a peptide drug, produce...

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Bibliographic Details
Published in:	Biomolecules (Basel, Switzerland) Vol. 15; no. 9; p. 1224
Main Authors:	Li, Zhuoran, Schneikert, Jean, Bal, Gürkan, Zuberbier, Torsten, Babina, Magda
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 25.08.2025
Subjects:	1-Phosphatidylinositol 3-kinase Agonists AKT protein Allergic diseases Allergic reaction Allergy Amino acids Antibodies Arrestin Bradykinin - analogs & derivatives Bradykinin - metabolism Bradykinin - pharmacology c-Jun protein Calcium channels Cell Degranulation - drug effects Cloning Degranulation desensitization drug allergy Edema Exocytosis Experiments Flow cytometry G proteins Humans Icatibant Immunoblotting Internalization JNK protein Kinases Ligands Mast cells Mast Cells - drug effects Mast Cells - metabolism Membrane proteins MRGPRX2 Nerve Tissue Proteins - metabolism Neuropeptides Proteins Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism Receptors, Neuropeptide - metabolism Signal Transduction - drug effects Skin Skin - cytology Skin - drug effects Skin - metabolism Skin tests Substance P Substance P - pharmacology Transcription factors California United States Massachusetts Germany St Louis Missouri United States > US Berlin Germany Ireland LAD2 cell line signaling drug allergy MRGPRX2 degranulation icatibant mast cells desensitization
ISSN:	2218-273X, 2218-273X
Online Access:	Get full text
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