Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial

Rifampicin doses of 40 mg/kg in adults are safe and well tolerated, may shorten anti-TB treatment and improve outcomes, but have not been evaluated in children. To characterize the pharmacokinetics and safety of high rifampicin doses in children with drug-susceptible TB. The Opti-Rif trial enrolled...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy Jg. 76; H. 12; S. 3237
Hauptverfasser:	Garcia-Prats, Anthony J, Svensson, Elin M, Winckler, Jana, Draper, Heather R, Fairlie, Lee, van der Laan, Louvina E, Masenya, Masebole, Schaaf, H Simon, Wiesner, Lubbe, Norman, Jennifer, Aarnoutse, Rob E, Karlsson, Mats O, Denti, Paolo, Hesseling, Anneke C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 12.11.2021
Schlagworte:	Child Child, Preschool Humans Infant Rifampin - adverse effects
ISSN:	1460-2091, 1460-2091
Online-Zugang:	Weitere Angaben
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