Schizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network

Abnormal connectivity of the anticorrelated intrinsic networks, the task-negative network (TNN), and the task-positive network (TPN) is implicated in schizophrenia. Comparisons between schizophrenic patients and their unaffected siblings enable further understanding of illness susceptibility and pat...

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Vydáno v:Schizophrenia bulletin Ročník 38; číslo 2; s. 285
Hlavní autoři: Liu, Haihong, Kaneko, Yoshio, Ouyang, Xuan, Li, Li, Hao, Yihui, Chen, Eric Y H, Jiang, Tianzi, Zhou, Yuan, Liu, Zhening
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.03.2012
Témata:
Adult
Case-Control Studies
Female
Frontal Lobe - pathology
Frontal Lobe - physiopathology
Functional Neuroimaging
Gyrus Cinguli - pathology
Gyrus Cinguli - physiopathology
Humans
Magnetic Resonance Imaging
Male
Neural Pathways - pathology
Neural Pathways - physiopathology
Parietal Lobe - pathology
Parietal Lobe - physiopathology
Prefrontal Cortex - pathology
Prefrontal Cortex - physiopathology
Schizophrenia - pathology
Schizophrenia - physiopathology
Siblings
Task Performance and Analysis
Temporal Lobe - pathology
Temporal Lobe - physiopathology
ISSN:1745-1701, 1745-1701
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Popis
Shrnutí:Abnormal connectivity of the anticorrelated intrinsic networks, the task-negative network (TNN), and the task-positive network (TPN) is implicated in schizophrenia. Comparisons between schizophrenic patients and their unaffected siblings enable further understanding of illness susceptibility and pathophysiology. We examined the resting-state connectivity differences in the intrinsic networks between schizophrenic patients, their unaffected siblings, and healthy controls. Resting-state functional magnetic resonance images were obtained from 25 individuals in each subject group. The posterior cingulate cortex/precuneus and right dorsolateral prefrontal cortex were used as seed regions to identify the TNN and TPN through functional connectivity analysis. Interregional connectivity strengths were analyzed using overlapped intrinsic networks composed of regions common to all subject groups. Schizophrenic patients and their unaffected siblings showed increased connectivity in the TNN between the bilateral inferior temporal gyri. By contrast, schizophrenic patients alone demonstrated increased connectivity between the posterior cingulate cortex/precuneus and left inferior temporal gyrus and between the ventral medial prefrontal cortex and right lateral parietal cortex in the TNN. Schizophrenic patients exhibited increased connectivity between the left dorsolateral prefrontal cortex and right inferior frontal gyrus in the TPN relative to their unaffected siblings, though this trend only approached statistical significance in comparison to healthy controls. Resting-state hyperconnectivity of the intrinsic networks may disrupt network coordination and thereby contribute to the pathophysiology of schizophrenia. Similar, though milder, hyperconnectivity of the TNN in unaffected siblings of schizophrenic patients may contribute to the identification of schizophrenia endophenotypes and ultimately to the determination of schizophrenia risk genes.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1745-1701
1745-1701
DOI:10.1093/schbul/sbq074