Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo

Breast cancers are heterogeneous, with the triple negative subtype being the most aggressive and lack of effective therapy. Cold atmospheric plasma has become a promising onco-therapeutic approach as demonstrated by many pre-clinical studies. We found from both in vitro and in vivo experiments that...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Free radical biology & medicine Ročník 124; s. 205 - 213
Hlavní autoři: Xiang, Liangjian, Xu, Xiaoyu, Zhang, Shuo, Cai, Dongyan, Dai, Xiaofeng
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 20.08.2018
Témata:
Apoptosis
Migration
Mouse model
Plasma-activated medium
Proliferation
Triple negative breast cancer
Mouse model
Proliferation
Plasma-activated medium
Migration
Triple negative breast cancer
Apoptosis
ISSN:0891-5849, 1873-4596, 1873-4596
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Breast cancers are heterogeneous, with the triple negative subtype being the most aggressive and lack of effective therapy. Cold atmospheric plasma has become a promising onco-therapeutic approach as demonstrated by many pre-clinical studies. We found from both in vitro and in vivo experiments that plasma-activated medium could selectively induce the apoptosis, inhibit the proliferation and migration of triple negative breast cancers rather than the other subtypes. We propose that it is the accelerated genome mutation rate, hyper-activated MAPK/JNK and NF-kB pathways of triple negative breast cancers that make them more vulnerable to plasma treatment than non-triple negative tumors, and MAPK/JNK and NF-κB signalings in response to reactive oxygen species generated by plasma that play deterministic roles in this differential therapeutic response. Our work contributes in establishing a correlation between plasma efficacy and cancer subtypes, which facilitates the clinical translation of plasma as a precision medicinal approach. [Display omitted] •PAM selectively halts TNBCs progression both in vitro and in vivo.•High p53 mutation rate in TNBC results in their vulnerability to redox crisis.•Hyperactivated JNK and NF-κB pathways in TNBCs contribute to their PAM sensitivity.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0891-5849
1873-4596
1873-4596
DOI:10.1016/j.freeradbiomed.2018.06.001