Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo

Breast cancers are heterogeneous, with the triple negative subtype being the most aggressive and lack of effective therapy. Cold atmospheric plasma has become a promising onco-therapeutic approach as demonstrated by many pre-clinical studies. We found from both in vitro and in vivo experiments that...

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Veröffentlicht in:	Free radical biology & medicine Jg. 124; S. 205 - 213
Hauptverfasser:	Xiang, Liangjian, Xu, Xiaoyu, Zhang, Shuo, Cai, Dongyan, Dai, Xiaofeng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 20.08.2018
Schlagworte:	Apoptosis Migration Mouse model Plasma-activated medium Proliferation Triple negative breast cancer Mouse model Proliferation Plasma-activated medium Migration Triple negative breast cancer Apoptosis
ISSN:	0891-5849, 1873-4596, 1873-4596
Online-Zugang:	Volltext
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Abstract	Breast cancers are heterogeneous, with the triple negative subtype being the most aggressive and lack of effective therapy. Cold atmospheric plasma has become a promising onco-therapeutic approach as demonstrated by many pre-clinical studies. We found from both in vitro and in vivo experiments that plasma-activated medium could selectively induce the apoptosis, inhibit the proliferation and migration of triple negative breast cancers rather than the other subtypes. We propose that it is the accelerated genome mutation rate, hyper-activated MAPK/JNK and NF-kB pathways of triple negative breast cancers that make them more vulnerable to plasma treatment than non-triple negative tumors, and MAPK/JNK and NF-κB signalings in response to reactive oxygen species generated by plasma that play deterministic roles in this differential therapeutic response. Our work contributes in establishing a correlation between plasma efficacy and cancer subtypes, which facilitates the clinical translation of plasma as a precision medicinal approach. [Display omitted] •PAM selectively halts TNBCs progression both in vitro and in vivo.•High p53 mutation rate in TNBC results in their vulnerability to redox crisis.•Hyperactivated JNK and NF-κB pathways in TNBCs contribute to their PAM sensitivity.
AbstractList	Breast cancers are heterogeneous, with the triple negative subtype being the most aggressive and lack of effective therapy. Cold atmospheric plasma has become a promising onco-therapeutic approach as demonstrated by many pre-clinical studies. We found from both in vitro and in vivo experiments that plasma-activated medium could selectively induce the apoptosis, inhibit the proliferation and migration of triple negative breast cancers rather than the other subtypes. We propose that it is the accelerated genome mutation rate, hyper-activated MAPK/JNK and NF-kB pathways of triple negative breast cancers that make them more vulnerable to plasma treatment than non-triple negative tumors, and MAPK/JNK and NF-κB signalings in response to reactive oxygen species generated by plasma that play deterministic roles in this differential therapeutic response. Our work contributes in establishing a correlation between plasma efficacy and cancer subtypes, which facilitates the clinical translation of plasma as a precision medicinal approach. Breast cancers are heterogeneous, with the triple negative subtype being the most aggressive and lack of effective therapy. Cold atmospheric plasma has become a promising onco-therapeutic approach as demonstrated by many pre-clinical studies. We found from both in vitro and in vivo experiments that plasma-activated medium could selectively induce the apoptosis, inhibit the proliferation and migration of triple negative breast cancers rather than the other subtypes. We propose that it is the accelerated genome mutation rate, hyper-activated MAPK/JNK and NF-kB pathways of triple negative breast cancers that make them more vulnerable to plasma treatment than non-triple negative tumors, and MAPK/JNK and NF-κB signalings in response to reactive oxygen species generated by plasma that play deterministic roles in this differential therapeutic response. Our work contributes in establishing a correlation between plasma efficacy and cancer subtypes, which facilitates the clinical translation of plasma as a precision medicinal approach.Breast cancers are heterogeneous, with the triple negative subtype being the most aggressive and lack of effective therapy. Cold atmospheric plasma has become a promising onco-therapeutic approach as demonstrated by many pre-clinical studies. We found from both in vitro and in vivo experiments that plasma-activated medium could selectively induce the apoptosis, inhibit the proliferation and migration of triple negative breast cancers rather than the other subtypes. We propose that it is the accelerated genome mutation rate, hyper-activated MAPK/JNK and NF-kB pathways of triple negative breast cancers that make them more vulnerable to plasma treatment than non-triple negative tumors, and MAPK/JNK and NF-κB signalings in response to reactive oxygen species generated by plasma that play deterministic roles in this differential therapeutic response. Our work contributes in establishing a correlation between plasma efficacy and cancer subtypes, which facilitates the clinical translation of plasma as a precision medicinal approach. Breast cancers are heterogeneous, with the triple negative subtype being the most aggressive and lack of effective therapy. Cold atmospheric plasma has become a promising onco-therapeutic approach as demonstrated by many pre-clinical studies. We found from both in vitro and in vivo experiments that plasma-activated medium could selectively induce the apoptosis, inhibit the proliferation and migration of triple negative breast cancers rather than the other subtypes. We propose that it is the accelerated genome mutation rate, hyper-activated MAPK/JNK and NF-kB pathways of triple negative breast cancers that make them more vulnerable to plasma treatment than non-triple negative tumors, and MAPK/JNK and NF-κB signalings in response to reactive oxygen species generated by plasma that play deterministic roles in this differential therapeutic response. Our work contributes in establishing a correlation between plasma efficacy and cancer subtypes, which facilitates the clinical translation of plasma as a precision medicinal approach. [Display omitted] •PAM selectively halts TNBCs progression both in vitro and in vivo.•High p53 mutation rate in TNBC results in their vulnerability to redox crisis.•Hyperactivated JNK and NF-κB pathways in TNBCs contribute to their PAM sensitivity.
Author	Dai, Xiaofeng Zhang, Shuo Xu, Xiaoyu Cai, Dongyan Xiang, Liangjian
Author_xml	– sequence: 1 givenname: Liangjian surname: Xiang fullname: Xiang, Liangjian organization: School of Biotechnology, Jiangnan University, Wuxi, China – sequence: 2 givenname: Xiaoyu surname: Xu fullname: Xu, Xiaoyu organization: Engineering Research Center of IoT Technology Applications (Ministry of Education), Department of Electronic Engineering, Jiangnan University, Wuxi, China – sequence: 3 givenname: Shuo surname: Zhang fullname: Zhang, Shuo organization: School of Biotechnology, Jiangnan University, Wuxi, China – sequence: 4 givenname: Dongyan surname: Cai fullname: Cai, Dongyan organization: Wuxi School of Medicine, Jiangnan University, Wuxi, China – sequence: 5 givenname: Xiaofeng surname: Dai fullname: Dai, Xiaofeng email: xiaofeng.dai@jiangnan.edu.cn organization: Wuxi School of Medicine, Jiangnan University, Wuxi, China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29870749$$D View this record in MEDLINE/PubMed
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Keywords	Mouse model Proliferation Plasma-activated medium Migration Triple negative breast cancer Apoptosis
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Snippet	Breast cancers are heterogeneous, with the triple negative subtype being the most aggressive and lack of effective therapy. Cold atmospheric plasma has become...
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SubjectTerms	Apoptosis Migration Mouse model Plasma-activated medium Proliferation Triple negative breast cancer
Title	Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo
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