Inappropriate glucagon and GLP-1 secretion in individuals with long-standing type 1 diabetes: effects of residual C-peptide

Aims/hypothesis Recent studies have demonstrated that residual beta cells may be present in some people with long-standing type 1 diabetes, but little is known about the potential impact of this finding on alpha cell function and incretin levels. This study aimed to evaluate whether insulin microsec...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Diabetologia Ročník 62; číslo 4; s. 593 - 597
Hlavní autoři: Thivolet, Charles, Marchand, Lucien, Chikh, Karim
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2019
Springer Nature B.V
Springer Verlag
Témata:
Adult
Area Under Curve
Beta cells
Blood Glucose - metabolism
C-Peptide - blood
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - metabolism
Female
Glucagon
Glucagon - blood
Glucagon-like peptide 1
Glucagon-Like Peptide 1 - blood
Glucagon-Secreting Cells - metabolism
Glucose Tolerance Test
Human Physiology
Humans
Incretins - metabolism
Insulin
Insulin - metabolism
Insulin-Secreting Cells - metabolism
Internal Medicine
Life Sciences
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Peptides
Secretion
Young Adult
Incretins
Insulin microsecretion
Type 1 diabetes
Pancreatic alpha cells
ISSN:0012-186X, 1432-0428, 1432-0428
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Aims/hypothesis Recent studies have demonstrated that residual beta cells may be present in some people with long-standing type 1 diabetes, but little is known about the potential impact of this finding on alpha cell function and incretin levels. This study aimed to evaluate whether insulin microsecretion could modulate glucagon and glucagon-like peptide-1 (GLP-1) responses to a mixed meal tolerance test (MMTT). Methods Adults with type 1 diabetes onset after the age of 15 years ( n  = 29) underwent a liquid MMTT after an overnight fast. Insulin microsecretion was defined when peak C-peptide levels were >30 pmol/l using an ultrasensitive assay. Four individuals with recent-onset type 1 diabetes were included as controls. Glucagon and GLP-1 responses were analysed according to C-peptide patterns. Results We found comparable peak values, Δ 0–max levels and AUCs of glucagon and GLP-1 responses in C-peptide-positive participants ( n  = 9) and C-peptide-negative participants ( n  = 16) with long-standing diabetes and in participants with recent-onset diabetes ( n  = 4). Mean glucagon levels, however, differed ( p  = 0.01). Mean GLP-1 responses were significantly lower according to C-peptide positivity ( p  < 0.001, ANOVA). Interestingly, GLP-1 levels correlated to glucagon values in C-peptide-positive participants with long-standing diabetes (Pearson’s r  = 0.915, p  = 0.004) and in participants with recent-onset diabetes ( p  < 0.001) but not in C-peptide-negative participants. Conclusions/interpretation The glucagon response to an MMTT in people with long-standing type 1 diabetes is not reduced by the presence of residual beta cells. The reduction of GLP-1 responses according to residual C-peptide levels suggests specific regulatory pathways.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0012-186X
1432-0428
1432-0428
DOI:10.1007/s00125-018-4804-y