Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease

Pepducins are membrane-tethered, cell-penetrating lipopeptides that target the cytoplasmic surface of their cognate receptor. Here, we report the first human use of a protease-activated receptor-1-based pepducin, which is intended as an antiplatelet agent to prevent ischemic complications of percuta...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology Jg. 36; H. 1; S. 189
Hauptverfasser:	Gurbel, Paul A, Bliden, Kevin P, Turner, Susan E, Tantry, Udaya S, Gesheff, Martin G, Barr, Travis P, Covic, Lidija, Kuliopulos, Athan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2016
Schlagworte:	Adult Aged Blood Platelets - drug effects Blood Platelets - metabolism Cell-Penetrating Peptides - administration & dosage Cell-Penetrating Peptides - adverse effects Cell-Penetrating Peptides - pharmacokinetics Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - therapy Dose-Response Relationship, Drug Female Half-Life Humans Infusions, Intravenous Lipopeptides - administration & dosage Lipopeptides - adverse effects Lipopeptides - pharmacokinetics Male Middle Aged Percutaneous Coronary Intervention - adverse effects Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - pharmacokinetics Platelet Function Tests Receptor, PAR-1 - antagonists & inhibitors Receptor, PAR-1 - metabolism Treatment Outcome coronary artery disease collagen aspirin risk factors lipopeptides
ISSN:	1524-4636, 1524-4636
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