TRIM28 Is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming

Since the discovery of induced pluripotent stem cells there has been intense interest in understanding the mechanisms that allow a somatic cell to be reprogrammed back to a pluripotent state. Several groups have studied the alterations in gene expression that occur as somatic cells modify their geno...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Jg. 35; H. 1; S. 147 - 157
Hauptverfasser:	Miles, Denise Catherine, de Vries, Nienke Alexandra, Gisler, Santiago, Lieftink, Cor, Akhtar, Waseem, Gogola, Ewa, Pawlitzky, Inka, Hulsman, Danielle, Tanger, Ellen, Koppens, Martijn, Beijersbergen, Roderick Leonardus, van Lohuizen, Maarten
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Oxford University Press 01.01.2017
Schlagworte:	Animals Cell Proliferation Cellular Reprogramming - genetics Chromatin Chromatin - metabolism Domains Endogenous retroviruses Endogenous Retroviruses - metabolism Epigenesis, Genetic Epigenetics Gene expression Gene Knockdown Techniques Genomes Histone-Lysine N-Methyltransferase Histones - metabolism Induced pluripotent stem cells Lysine - metabolism Methylation Mice, Transgenic Models, Biological Pluripotency Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Reprogramming Retroviridae RNA, Small Interfering - metabolism Somatic cells Stem cells Trim28 Tripartite Motif-Containing Protein 28 - metabolism Up-Regulation - genetics Epigenetics Reprogramming Induced pluripotent stem cells Trim28
ISSN:	1066-5099, 1549-4918, 1549-4918
Online-Zugang:	Volltext
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